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Gabapentin to reduce seizures from tramadol?

J

Justin Sane 53

Bluelighter
Joined
Feb 5, 2011
Messages
93
In theory, would it be possible to use gabapentin (neurontin) to reduce to the risk of seizure caused by tramadol? Let's say 180 mg codeine, 7.5 mg oxycodone, and 100 mg tramadol were to be taken. how much gabapentin should one take for max anti seizure capability and how soon before the other drugs
 
The typical starting anti-epileptic dose for gabapentin is 300mg three times a day, and its allowable to titrate up to a maximum of 3600mg per day. If you take it regularly, though, discontinuing it will make you more succeptable to seizures, so keep that in mind.

Drug dosing questions belong in BDD, so I'll move this over there for you.

-->BDD
 
It should work in theory. I'd take the 300mg dose maybe an hour before the other drugs, then perhaps six hours later as well just to cover it.

Be aware that gabapentin could add increased CNS depression as well.
 
It should theoretically help atleast abit though i don't know how strong of a anti-convulsant gabapentin is compared to say valproate. I still wouldnt take more then 400mg's of tramadol in a day to be on the safe side of things.

Gabapentin definetely potentiates the nodding effect of opioids but taking it right before certain opiates namely hydrocodone and oxycodone can actually lower the bioavailability of the opiate. I have no idea if this goes for tramadol or not though.
 
Just a little off topic... But why bother with the 100mg trama anyway? Just pop another 70-100 mg of codeine or something.
 
Justin Sane 53 said:
In theory, would it be possible to use gabapentin (neurontin) to reduce to the risk of seizure caused by tramadol? Let's say 180 mg codeine, 7.5 mg oxycodone, and 100 mg tramadol were to be taken. how much gabapentin should one take for max anti seizure capability and how soon before the other drugs
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You wouldn't need to take Gabapentin to try and reduce seizures at 100mg of Tramadol. Tramadol becomes a seizure risk once you go beyond 400mg.

Taking Gabapentin would reduce the risk but I wouldn't risk it.
 
^ Tramadol presents a seizure risk at lower doses too, especially for those who have had one before. Though in that case the OP maybe shouldn't be messing around with it.
 
Well since Tramadol lowers the seizure threshold then really only those who are predisposed to seizures would be the ones at increased risk at therapeutic doseages, (or if you are combining Tramadol wth other drugs that might reduce the seizure threshold as well). This would be why some doctors might not persrcibe Tramadol in the first place..
 
K'd-OUT-in-AZ said:
Really? I have never heard that before. At what doses?
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It does cause seizures at lower doses then 400mg's and if you have a history of a seizure disorder you really should not be taking tramadol at all. At what doses i have no idea though id imagine it depends again alot on the person and how high their seizure threshold is.
 
Yes, tramadol lowers the seizure threshold across the board. It's not like you're fine at 399 mg, but at 400 mg you're risking seizure. It can cause seizures basically at any dose. It all depends on the person, their history, what other meds they're taking and their sensitivity to the drug.
 
I've heard of seizures as low as 150 mg by itself, not to mention the risk after combining it with certain drugs. So it cam actually lessen the euphoria, paranoid android? That would be good to know, i'll avoid using it next time.
 
If I knew you could get seizures at doses below 400mg I probably wouldn't have used it. I was on pregabalin and clonazepam most of the time when I used Tramadol so the chances for seizures would probably decrease. Although I have had a seizure before but it was due to cold turkey benzodiazepine withdrawal.
 
Justin Sane 53 said:
I've heard of seizures as low as 150 mg by itself, not to mention the risk after combining it with certain drugs. So it cam actually lessen the euphoria, paranoid android? That would be good to know, i'll avoid using it next time.
Click to expand...

Well it won't lessen the euphoria of the tramadol thats if you get any euphoria off it at all to begin with. Some just din't and im one of them and it just fucks with my bipolar. It can lower the bioavailability of certain opiates mainly hydrocodone and oxycodone both by about 15% if you take the gabapenbtin right beforehand or with it. I don't know if it has this effect on tramadol or any other opiates/ opioids though. I know if you take gabapentin a certain time after taking certain opiates namely hydrocodone, oxycodone and morphine it boosts the bioavailability of the gabapentin by 15%, 15% and a whopping 50% with the morphine. Gabapentin does not boost the bioavailability of any opiates though unfortunatly.

So if you take abit of gabapentin say 4 hours before the tramadol and another bit 2 hours after id say that would cut down on any seizure risk and maybe help some of the negative effects of the tramadol. Watch out for the drunkenness that the gabapentin and opioid combo can cause though. As well as the CNS depression of course.
 
^^ He meant the gabapentin decreased the effects, not the tramadol. I'd imagine one would take the tramadol to potentiate the other drugs, rather than it for euphoria alone.
 
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