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Gabapentin-like drugs (in nature?)

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Jamshyd

Jamshyd

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The impression I get is that, aside from Pregabalin, Gabapentin is an entirely unique drug pharmacologically-speaking.

What other drugs (not necessarily analogues) have similar effects on the calcium channel that you are aware of?

Are there any natural compounds with such properties?
 
I've takin "neurotin" many times, When I take high doses(2,000mg+) it's almost like taking those Amanita muscaria(fly agaric) mushrooms. Everything feels like it's compressing, and some crazy closed eyed visuals, like riding a roller coaster.
 
^ Thanks guys but I honestly don't give a rat's ass about what other high it "feels" like, hence my posting it in ADD.

I consider Gabapentin as medicine, and a damn good one.

It just baffles me how little there is in nature (or even in the lab) that mimics it's pharmacological action.
 
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What has ADD come to...?
 
Ziconotide is also thought to have the N-type calcium channel blocker effect, and is used for chronic pain. That's as much I am able to dig up on the subject at the moment.

EDIT: Found some more drugs with similar profile: Levetiracetam, Oxcarbazepine, Lamotrigine, Topiramate. Some of these are thought to block sodium channels instead, though, so take from that what you will.

EDIT2: Oh, sorry, I completely missed the nature part of your request at first. It is curious indeed if nothing with similar action has been discovered in nature. I'm sure they exist somewhere, though. Nature is full of interesting chemicals science hasn't found yet.
 
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That's a great question. I'd also be interested in the answer, since I am a complete pharmacology failure.

Said that, I understand your frustration... Gabapentin is certainly a mysterious drug, what with the lawsuits and all.

And what's more important... I think there's so much wasted potential for human benefit that's gone unnoticed. You know, something that Albert Hoffman would say.

I feel it has a certain 'goodness' vibe about it that is rare in my book as far as synthetic pharms go. (as opposed to, say, Zolpidem :p). YMMV, of course.

Actually I'm much more interested in natural medicines, it's a shame everything has to be sold and greedizised. :X
 
Phenytoin (dilantin) works in pretty much the same way. But it has some really nasty side effects... like tooth and gum loss at the least.
 
i can get gabapentins in huge bulk for literally pennies, and i tried it once and it did nothing. what more do you want?

^ I have just searched around BL and te net to find good recreation stories of gabapentin and cant really find any. a coiuple newbs seem to think it's a lot like E. i cant imagine how.

it seems its revered by people who like long words more than anything :D
 
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yeah, they are extremely easy for me to get, but I never got any real good but sleep... What did I miss? I have eaten 7 or 8 at once... I think they were 300 mg...8)
 
Jam and Negro, I have an unmedicated seizure disorder and anxiety problems for which I just came off 4mg a day of klonopin (jail detox). it's been 3 weeks and I am at a new psychiatrist.. when I asked her about neurontin she said it was a "bogus drug". I asked her about it's use for anti-anxiety and she ended up scripting me hydroxyzine which does nothing.

she wants to put me on depakote for hypomania but I think that is a little extreme. plus I've already refused dexedrine and said I don't want to be back on benzo's I would think she would have a lot of respect for that. I want something clean like neurontin and not dilantin or lamictal. well, lamictal was OK but dilantin was horrible. could I try and see if she could get me on both? suggestions? I seem like a good candidate

sorry bout the thread hijack, probably doesn't alleviate your concers about ADD =D
 
i took 900 mg tonight and it did practically, essentially nothing. i know this sound hyprocrtical haha, but i was helping a budy out and getting like 20 300mg pills for 10$
 
Indeed, the majority of the responses in this thread are fucking ridiculous - like youtube comment ridiculous - but then... the question was of considerably dubious utility itself. "What naturally occurring substances have the pharmacodynamical properties of gabapentin and pregabalin - i.e. alpha2delta antagonism?" Would the answer to that question constitute useful, actionable, or interesting information at all? Since you have your alpha2delta antagonists already, what good would it do to acquire and make use of additional members of that pharmacodynamic class? Is this just pointless curiosity?

For what it's worth, I'll hazard a guess that there exist in nature a fair number of such substances and that those simply have yet to be discovered, but that of course isn't anything more substantial than am extremely poorly informed hunch.

ADD Bluelight is in the shitter without question (and BDD Bluelight always was), and I'm sorry to have to acknowledge that I contributed to it being here not to an insignificant extent. Oh well, time to move on and [help] ruin some other pharmacology forum.
 
ControlDenied said:
i took 900 mg tonight and it did practically, essentially nothing. i know this sound hyprocrtical haha, but i was helping a budy out and getting like 20 300mg pills for 10$
Click to expand...

Cmon man you been here for a long time you should know that there is no prices outside of the price thread.
 
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