RxVeritas
Bluelighter
- Joined
- Jun 14, 2023
- Messages
- 175
Gabapentin is an interesting drug in my opinion. It's not metabolized via the cytochrome P450, so my initial assumption was that the slight potentiating effect that I get from taking it with kratom, suboxone, tramadol or oxycodone (although unfortunately I haven't had the resources to test that as much) would be more or less the same with other opiates, as there is no CYP3A4 component.
For context, I'm prescribed gabapentin 800mg x 3 daily, and I almost always cut the pills into quarters (or occasionally even smaller pieces) and I won't give you my whole gabapentin dosing regimen spiel, but long story short I take the prescribed amount most days, and take the majority of it earlier in the day. If I intend to use it as an opiate potentiaor I usually make sure to take a couple doses in the preceeding hour and a half or so, as well as other things, but I don't think they're relavent in this case.
Both studies and experience reports seem to indicate that, for some reason yet unbeknownst to me (although it's possible I didn't dig hard enough), gabapentin seems to have a pronounced effect on the bioavailability of hydrocodone. When gabapentin is taken one (or two? I don't recall exactly) hours before, it decreases the bioavailability of hydrocodone by something like 15%. It's also interesting that when taking gabapentin an hour after hydrocodone, apparently the bioavailabilty of the gabapentin *actually increases as well*.
A couple days ago I got a small script for Vicodin 5mg.
Now, taking into consideration that for the first half of the day I am continously dosing gabapentin (every 15-30 miniutes, depending on the specific dose and the day) it would make sense to me that taking hydrocodone at any point (exluding first thing in the morning) should lead to a decrease in bioavailibity, because of the gabapentin. To me this effect definitely seemed to be more substantial than just a placebo, as I definitely didn't feel like I was getting as much out of the hydrocodone as I have in the past, before I was taking gabapentin the way I currently do (which is OPTIMAL, and I've brought it up before so I won't do it here lol, if you're really curious just PM me lol).
I got a small script for oxycodone 5mg today, and as far as I can tell it mixes great with gabapentin the way I take it, and there is definitely potentiation, and that makes sense to me, so yay!
Does anybody know the mechanism behind hydrocodone exhibiting such a strange, highly time-dependent relationship in regards to gabapentin and the bioavailibity of both?
I'm also curious if there are other opiates that are diminished in effect after taking gabapentin, as hydrocodone seems like an anomoly in this respect, and it's really eatin' away at the back of my mind the past couple days.
Can anybody help my understand any of things?
Mods: please move this if you feel it necesary.
For context, I'm prescribed gabapentin 800mg x 3 daily, and I almost always cut the pills into quarters (or occasionally even smaller pieces) and I won't give you my whole gabapentin dosing regimen spiel, but long story short I take the prescribed amount most days, and take the majority of it earlier in the day. If I intend to use it as an opiate potentiaor I usually make sure to take a couple doses in the preceeding hour and a half or so, as well as other things, but I don't think they're relavent in this case.
Both studies and experience reports seem to indicate that, for some reason yet unbeknownst to me (although it's possible I didn't dig hard enough), gabapentin seems to have a pronounced effect on the bioavailability of hydrocodone. When gabapentin is taken one (or two? I don't recall exactly) hours before, it decreases the bioavailability of hydrocodone by something like 15%. It's also interesting that when taking gabapentin an hour after hydrocodone, apparently the bioavailabilty of the gabapentin *actually increases as well*.
A couple days ago I got a small script for Vicodin 5mg.
Now, taking into consideration that for the first half of the day I am continously dosing gabapentin (every 15-30 miniutes, depending on the specific dose and the day) it would make sense to me that taking hydrocodone at any point (exluding first thing in the morning) should lead to a decrease in bioavailibity, because of the gabapentin. To me this effect definitely seemed to be more substantial than just a placebo, as I definitely didn't feel like I was getting as much out of the hydrocodone as I have in the past, before I was taking gabapentin the way I currently do (which is OPTIMAL, and I've brought it up before so I won't do it here lol, if you're really curious just PM me lol).
I got a small script for oxycodone 5mg today, and as far as I can tell it mixes great with gabapentin the way I take it, and there is definitely potentiation, and that makes sense to me, so yay!
Does anybody know the mechanism behind hydrocodone exhibiting such a strange, highly time-dependent relationship in regards to gabapentin and the bioavailibity of both?
I'm also curious if there are other opiates that are diminished in effect after taking gabapentin, as hydrocodone seems like an anomoly in this respect, and it's really eatin' away at the back of my mind the past couple days.
Can anybody help my understand any of things?
Mods: please move this if you feel it necesary.