GABAergics effects on LTP

[narutokun]

^I understand the principle of LTP as it should be understood (?).
If you want me to write a full report on LTP/LTD here I would but it has been years since I read a few abstracts on it and I just started college so I don't have any time to do that. I don't have neurophysiology on this semester so maybe in the future I can post something more detailed. I obviously cannot post what I think of the concept as being veridic since it's still being studied and subject to changes.
For me basicaly it's a pre-synaptic neuron and a post-synaptic neuron being subjected to stimuli which will improve their communication over the synapse.

(...)enhanced communication is predominantly carried out by improving the postsynaptic cell's sensitivity to signals received from the presynaptic cell. These signals, in the form of neurotransmitter molecules, are received by neurotransmitter receptors present on the surface of the postsynaptic cell. LTP improves the postsynaptic cell's sensitivity to neurotransmitter in large part by increasing the activity of existing receptors and by increasing the number of receptors on the postsynaptic cell surface.

Malenka R, Bear M (2004). "LTP and LTD: an embarrassment of riches". Neuron 44 (1): 5–21.

 

[leungkachong]

Sorry, I'm in a rush off the computer, but:

The traditional neurochemical view of LTP potentiation is that it is mediated first by NMDA (mGluR) activation as a result of Ca++ increase, as a result of voltage gated Ca++ channels activated by the AP, which is why increase in AP = strengthening of synapse hebbian style). That all causes kinases to phosphorylate AMPA receptors (causing increased conductance), and even insert more AMPA receptors into membranes.

So the playas for LTP are NMDA and AMPA.

 

[narutokun]

^I'm sorry, what do you even mean by

LTP potentiation

?

 

[swilow]

Probably the same thing as when people say PIN number. Its called a slip of the tongue. Questioning that one little thing doesn't make you sound intelligent....

 

[narutokun]

^Redundancy doesn't really appeal to me, do you want my apologies?

 

[Jamshyd]

^I'm sorry, what do you even mean by ?

He means exactly what LTP is, he just added the last word due to being in a rush.

This good man is a neuropharmacology major.

You claim you understand LTP "as it should be understood", yet you post stuff that proves otherwise.

Sorry to be blunt, but if you don't understand what leung said then you will gain nothing out of discussing the subject.

 

[narutokun]

He means exactly what LTP is, he just added the last word due to being in a rush.

This good man is a neuropharmacology major.

You claim you understand LTP "as it should be understood", yet you post stuff that proves otherwise.

Sorry to be blunt, but if you don't understand what leung said then you will gain nothing out of discussing the subject.

I couldn't give less of a shit about you being 'blunt', I don't know what happens but in the end you always turn up against me. I just turned 17 and I just entered college. I haven't even had neurophysiology and I'm not even sure I'm going to have neuroPHARMACOLOGY this year. All I know so far about pharmacology and many other things is because I HAVE INTEREST in those things. I borrowed books from friends and looked up online. Those things aren't taught in high school. I'm a fucking autodidact, I was expecting at least a little respect for that. I doubt that a normal person in my age (expept for genius) knows as much as I do about these things. I try my best to understand the things that I read and try to learn. I wasn't expecting anyone to praise me for that from the beggining, I cared, even though I know those were merely illusions. "Oh hey, look, he's an interested boy, let's congratulate him or something instead of flaming him on the forums" yeah, right.
I can't wish the same scenario happened to you because you are already old. But I wish you never find yourself in this kind of sitaution in life.
I only hope you could be more humble and understand that I have no academic formation YET. In four or five years then you'll be seeing my name on papers, etc (you'll be seeing but you won't know it's me cause obviously I'm not gonna tell you my name or whatever). Then I would like to know what you will feel like, that boy I used to make a door-mat of is now a renowned Dr. in his field. While you, oh well, I have no idea what you'll be.
I don't give a shit for titles, while you seem to love them, major of this, major of that, etc. What are you yourself? I suspect you're not even a barchelor because intelligent people don't brag about titles and such. The few teachers I met in college these past days never bragged about their titles and they are all Phds with a higher honor that we have here which is merely a title, representing you supposedly acheieved the maximum status on your academic carreer.
Oh yes, btw, I did understand what your so called neuropharm major said, and clearly I haven't posted any conflictuous posts.
Maybe you haven't had your ketamine fix today? Who knows.

 

[Jamshyd]

"Wisest is he who knows he does not know" - socrates

ps. I will ignore your ad-homs.

pss. Never ask me for advice again, because obviously you have no idea what respect is.

 

[narutokun]

^Your egocentrism is ridiculous. Pretending not to understand what I just wrote which is clearly the truth is pathetic. Quotating socrates does not impress me, neither does it make me think of you as a smart person, something your ego probably needs satisfied. I never asked for your advice in this thread, those who responded responded out of free will. OBVIOUSLY, you do not know what respect is, treating me like trash in order to fulfill your ego, with your alledged subtle polite phrases: 'sorry to be blunt', etc. Do you think I buy that shit? That you do not enjoy feeling "superior" to someone else? When that someone is a 17 year old freshman who just entered college? Isn't that just sad? I'm not a fool, please.
Oh here's another quotation or popular saying for you: the truth hurts
oh sorry, I don't know whom that one belongs to.

 

[leungkachong]

I didn't know a typo was to cause such a kerfluffle. Thanks for those who didn't see it as a big deal. Either way, what I posted is about as fullcircle an explanation of how an increase in AP causes a strengthened synapse in only a couple lines.

I can identify with you n-kun (not the aggression) for being someone who dug into (neuro)science well before highschool was up. I remember highschool leisure reading like 'Rapid Interpretation of EKGs' and neuroanatomy books discussing the elegant maintenance of somato-/retino-/tono- topic organization of sensory signals that allow us to learn about the brain using the brain.

*ACTUALLY RELEVANT SECTION OF POST BEGINS HERE*
I just thought I'd also mention as you were interested in GABA that most of the GABA-mediated effects on LTP work by the opening of Cl- channels which are located at the site of signal integration at the base of the axon (ie - where signals summate to initiate AP), where the Cl- shunts the AP. Same general idea also at the terminal arborizations (branches at the end of an axon). It interferes with LTP because it reduces the chance of AP (at the base), and strength of depolarization (at the arborizations), so that the neuron doesn't get the intracellular Ca++ necessary to activate the NMDArs (which are the 'first-step' in the LTP cascade).
*END OF ANYTHING WORTH READING*

Watch your own typos too if you find them so offensive

 

[narutokun]

I didn't know a typo was to cause such a kerfluffle. Thanks for those who didn't see it as a big deal. Either way, what I posted is about as fullcircle an explanation of how an increase in AP causes a strengthened synapse in only a couple lines.

I can identify with you n-kun (not the aggression) for being someone who dug into (neuro)science well before highschool was up. I remember highschool leisure reading like 'Rapid Interpretation of EKGs' and neuroanatomy books discussing the elegant maintenance of somato-/retino-/tono- topic organization of sensory signals that allow us to learn about the brain using the brain.

*ACTUALLY RELEVANT SECTION OF POST BEGINS HERE*
I just thought I'd also mention as you were interested in GABA that most of the GABA-mediated effects on LTP work by the opening of Cl- channels which are located at the site of signal integration at the base of the axon (ie - where signals summate to initiate AP), where the Cl- shunts the AP. Same general idea also at the terminal arborizations (branches at the end of an axon). It interferes with LTP because it reduces the chance for AP (at the base), and strength of depolarization (at the arborizations), so that the neuron doesn't get the intracellular Ca++ necessary to activate the NMDArs (which are the 'first-step' in the LTP cascade).
*END OF ANYTHING WORTH READING*

Watch your own typos too if you find them so offensive

The 'aggression' was the only mean of defence in such a offensive situation.
Thank you when you say you can identify with the position I am at now. Also thanks for the GABA mediated effects on LTP, that was the information I was seeking from the beggining and in the end after you explained the simplified mechanisms I was able to conclude what I had in mind from the begging, thank you.

 

[swilow]

Using paragraphs is smart Naru- it makes you seem less like a maniac. :

Those things aren't taught in high school. I'm a fucking autodidact, I was expecting at least a little respect for that. I doubt that a normal person in my age (expept for genius) knows as much as I do about these things.

HEHEHEHEHAHAHAHAHA!!!!!!!! Are you serious? You don't know anything!! 8) :D Thats the point by and large. If you did, you certainly wouldn't write the inane prattle that you do here.

I try my best to understand the things that I read and try to learn. I wasn't expecting anyone to praise me for that from the beggining, I cared, even though I know those were merely illusions. "Oh hey, look, he's an interested boy, let's congratulate him or something instead of flaming him on the forums" yeah, right.
I can't wish the same scenario happened to you because you are already old. But I wish you never find yourself in this kind of sitaution in life.

It must be tough man; can you get refugee status? Your not going to get sympathy- sorry about that.

I only hope you could be more humble and understand that I have no academic formation YET. In four or five years then you'll be seeing my name on papers, etc (you'll be seeing but you won't know it's me cause obviously I'm not gonna tell you my name or whatever). Then I would like to know what you will feel like, that boy I used to make a door-mat of is now a renowned Dr. in his field. While you, oh well, I have no idea what you'll be.

Alright, heres the fun- Naru says: "I only hope you could be more humble" leading on to "In four or five years then you'll be seeing my name on papers" (I hope you don't mean a death certificate by that) anyway, back to the fun- more humility "Then I would like to know what you will feel like, that boy I used to make a door-mat of is now a renowned Dr. in his field". Firstly, your going to have to BLAST through med school man. But then- "While you, oh well, I have no idea what you'll be."- a mean and baseless insult, indicating a lot more then anything you've otherwise said.

I don't give a shit for titles, while you seem to love them, major of this, major of that, etc. What are you yourself? I suspect you're not even a barchelor because intelligent people don't brag about titles and such.

See my bit above in regards to titles etc. BTW, why are you replying to Jamshyd? He didn't say he had the 'barchelor'. I think he is a 'barchelor' at least in social terms though, fwiw.

The few teachers I met in college these past days never bragged about their titles and they are all Phds with a higher honor that we have here which is merely a title, representing you supposedly acheieved the maximum status on your academic carreer.

Huh? That doesn't even make sense- but I would laugh so hard if a professor at my Uni bragged about his qualifications; he sort of embodies them, so its kind of assumed he is qualified. I dunno, I think thats what professors are all about...

Oh yes, btw, I did understand what your so called neuropharm major said, and clearly I haven't posted any conflictuous posts. Maybe you haven't had your ketamine fix today? Who knows.

End of nasty transmission.

You are in WAY over your head man....Why can't you see the connection between the amount of negativity you receive and the amount you output? You expect people to act as if you ask valid questions, but you never listen to answers. You will not accept medical fact until it agrees with what YOU want. That is a sign of immaturity. You waste peoples time (actually, I've had a ball dissecting your rather bile) and, while you may be intelligent, you come across as the opposite- you don't do yourself any favours by attacking people.

 

[Ham-milton]

"Oh hey, look, he's an interested boy, let's congratulate him or something instead of flaming him on the forums"

What? You thought we'd congratulate you? What, because you were interested? If you haven't noticed, we generally restrict praise for actually doing something useful or at least really cool.

Like my friend dims always said: "post videos" about any stupid thing I was instructed to do. Instantly turns the privately moronic into a spectater sport.
[just kidding really, videos of you shooting up benzo pills are sure to be boring] I never was half the dick he was.

(if you happen to read this, get well soon)

 

[leungkachong]

Does anyone happen to have anything to contribute or correct on my description of the method of action for the effect of GABAminergics effects on LTP 3 off-topics above? What I described is on a very short timescale.. anything about post-down/upregulation, changes in gene expression, etc and their physiological consequences?

 

[narutokun]

Using paragraphs is smart Naru- it makes you seem less like a maniac. :


HEHEHEHEHAHAHAHAHA!!!!!!!! Are you serious? You don't know anything!! 8) :D Thats the point by and large. If you did, you certainly wouldn't write the inane prattle that you do here.

It must be tough man; can you get refugee status? Your not going to get sympathy- sorry about that.

Alright, heres the fun- Naru says: "I only hope you could be more humble" leading on to "In four or five years then you'll be seeing my name on papers" (I hope you don't mean a death certificate by that) anyway, back to the fun- more humility "Then I would like to know what you will feel like, that boy I used to make a door-mat of is now a renowned Dr. in his field". Firstly, your going to have to BLAST through med school man. But then- "While you, oh well, I have no idea what you'll be."- a mean and baseless insult, indicating a lot more then anything you've otherwise said.

See my bit above in regards to titles etc. BTW, why are you replying to Jamshyd? He didn't say he had the 'barchelor'. I think he is a 'barchelor' at least in social terms though, fwiw.

Huh? That doesn't even make sense- but I would laugh so hard if a professor at my Uni bragged about his qualifications; he sort of embodies them, so its kind of assumed he is qualified. I dunno, I think thats what professors are all about...

End of nasty transmission.

You are in WAY over your head man....Why can't you see the connection between the amount of negativity you receive and the amount you output? You expect people to act as if you ask valid questions, but you never listen to answers. You will not accept medical fact until it agrees with what YOU want. That is a sign of immaturity. You waste peoples time (actually, I've had a ball dissecting your rather bile) and, while you may be intelligent, you come across as the opposite- you don't do yourself any favours by attacking people.

I do not deem myself smart or intelligent, but there's an awful trait of my personality that does not allow other people to make me look ridiculous, I'm sorry. Besides Jamshyd having probably read my post and noticed it was as if he was looking in the mirror, you try to back him up with this stupid shit?
You're the one's over your head. I try putting an end to this here as this isn't intelligent at all.

 

[MattPsy]

narutokun: from one young person to another - it pays to respect those who know more than you... especially when you're receiving the favour of them giving their knowledge to you - essentially for free. The only payment they ask for is a little respect, which is entirely deserved on their part.
There is a lot of very talented, creative, intelligent people here. Make good use of them, and extend common courtesy.

 

[Jamshyd]

Does anyone happen to have anything to contribute or correct on my description of the method of action for the effect of GABAminergics effects on LTP 3 off-topics above? What I described is on a very short timescale.. anything about post-down/upregulation, changes in gene expression, etc and their physiological consequences?

My friend, can you please describe your theory in more detail, preferably with less acronyms? (I know, those neuro profs managed to get you into shorthand-speak, I don't blame you ).

ps. for the fifth time, contact me, dagnammit! I'm back in town.