evilpudel666
Greenlighter
- Joined
- Jul 28, 2014
- Messages
- 1
Hi, folks! 
First of all, I'm new here. I will introduce myself later in more detail, for the moment let's just say, that I've been experimenting with some substances over the past years and BL has always been a great source of information. Since I've had some issues with alcohol and GABA-B agonists seem to be of help in this field, I developed a growing interest for these substances, namely Phenibut and Baclofen.
So here’s the part that puzzles me: It seems that most people notice pleasant effects from the drug during the time when actually blood concentrations of PB are falling or even when its already been cleared from the system. Also for baclofen, many of the alcoholics on the german baclofen/alcoholism forum claim that, rather than having constant blood levels of BAC, they notice positive effects when they have a “spike” of bac concentration one or more times a day. So the desired effects do not seem do derive from GABA-B activation itself but from some of the brains reaction to it. Does anyone have a theory as to what the mechanism behind that could be?
So here’s a theory:
As seen here
http://www.ncbi.nlm.nih.gov/pubmed/21255015
http://www.sciencedirect.com/science/article/pii/S0014299911009587
GABA-B activation triggers BDNF expression. Since BDNF is involved in learning and antidepressant action, it could perfectly explain some of the nootropic and mood anhancing effects of PB.
BDNF is increased naturally by exercise (see http://jn.physiology.org/content/88/5/2187.short) or learning (http://www.nature.com/neuro/journal/v3/n6/abs/nn0600_533.html; http://www.sciencedirect.com/science/article/pii/S0896627310002382) and induces a state of relaxation and enhanced neuroplasticity during which new information seems to be integrated and new neuronal connections are being formed. Therefore it makes sense, that BNDF usually accumulates during the day, especially when there was a lot of novel experience within that day and leads to a restful sleep (as experienced under PB) during which that information is assimilated (see http://www.researchgate.net/publica...sleep_homeostasis/file/3deec524d7cd336999.pdf).
In simpler words, PB seems to lead your brain to believe that you’ve just done the best workout of your life or learned a very valuable lesson, therefore inducing that calm state of relaxation/assimilation which usually happens after such events. You’re perfectly contempt with yourself, muscles are relaxing and you think that you’ve just experienced the most awesome day.
This would also explain the rapid development of tolerance to PB, especially when used within the same context all the time, because there simply is no “novel” information to assimilate anymore. An interesting topic of research would be, if PB could become active again, when paused and used in another environmental context.
Any thoughts/comments would be greatly appreciated.
First of all, I'm new here. I will introduce myself later in more detail, for the moment let's just say, that I've been experimenting with some substances over the past years and BL has always been a great source of information. Since I've had some issues with alcohol and GABA-B agonists seem to be of help in this field, I developed a growing interest for these substances, namely Phenibut and Baclofen.
So here’s the part that puzzles me: It seems that most people notice pleasant effects from the drug during the time when actually blood concentrations of PB are falling or even when its already been cleared from the system. Also for baclofen, many of the alcoholics on the german baclofen/alcoholism forum claim that, rather than having constant blood levels of BAC, they notice positive effects when they have a “spike” of bac concentration one or more times a day. So the desired effects do not seem do derive from GABA-B activation itself but from some of the brains reaction to it. Does anyone have a theory as to what the mechanism behind that could be?
So here’s a theory:
As seen here
http://www.ncbi.nlm.nih.gov/pubmed/21255015
http://www.sciencedirect.com/science/article/pii/S0014299911009587
GABA-B activation triggers BDNF expression. Since BDNF is involved in learning and antidepressant action, it could perfectly explain some of the nootropic and mood anhancing effects of PB.
BDNF is increased naturally by exercise (see http://jn.physiology.org/content/88/5/2187.short) or learning (http://www.nature.com/neuro/journal/v3/n6/abs/nn0600_533.html; http://www.sciencedirect.com/science/article/pii/S0896627310002382) and induces a state of relaxation and enhanced neuroplasticity during which new information seems to be integrated and new neuronal connections are being formed. Therefore it makes sense, that BNDF usually accumulates during the day, especially when there was a lot of novel experience within that day and leads to a restful sleep (as experienced under PB) during which that information is assimilated (see http://www.researchgate.net/publica...sleep_homeostasis/file/3deec524d7cd336999.pdf).
In simpler words, PB seems to lead your brain to believe that you’ve just done the best workout of your life or learned a very valuable lesson, therefore inducing that calm state of relaxation/assimilation which usually happens after such events. You’re perfectly contempt with yourself, muscles are relaxing and you think that you’ve just experienced the most awesome day.
This would also explain the rapid development of tolerance to PB, especially when used within the same context all the time, because there simply is no “novel” information to assimilate anymore. An interesting topic of research would be, if PB could become active again, when paused and used in another environmental context.
Any thoughts/comments would be greatly appreciated.
