Furfural and delta-hexachlorocyclohexane

[Hammilton]

On the subject of fusel oil constitutents, furfural was the most interesting to me. I'm wondering how this is metabolized? Does this open up like GBL does?

I don't think it does, but I dunno. According to wikipedia, consumption produces euphoria, dizziness, headache, etc- the typical results of ethanol consumption.

It's similar to GBL, but the difference is important; this won't become GHB, obviously. So basically: is the intoxication due to furfural itself or a metabolite?

Second, I received some private communication regarding delta-hexachlorocyclohexane, and it got my interest. According to CTD, it interacts with the following genes:

Main
GABRG2 GABRA1 GABRB1 GABRB2
Less
SHGB STAR AR CAT ESR1 ESR2

I'm familiar with the first four, but the last six are meaningless to me. No idea what they are, but given the degree of interaction, I don't think they're relevant.

There are a whole mix of isomers of this substance, but the one of importance is delta, it seems. I believe this is the most potent, and apparently the least likely to cause cancer. Still: don't perceive my interest as a reason to take this drug. I can't think of a worse idea.

I'm pretty sure that it's very similar to benzodiazepines in effect, and I found a paper describing it as "very potent" in this respect, but I seem to have irrepairably lost it.

 

[wungchow]

tetrahydrofuran activates the GABA-B receptor in a manner similar to GHB, my guess is furfural would be active too (but not too pleasant)

source

 

[flacky]

Wouldn't the double bonds present a problem?

 

[vecktor]

Second, I received some private communication regarding delta-hexachlorocyclohexane, and it got my interest. According to CTD, it interacts with the following genes:

Main
GABRG2 GABRA1 GABRB1 GABRB2
Less
SHGB STAR AR CAT ESR1 ESR2

I'm familiar with the first four, but the last six are meaningless to me. No idea what they are, but given the degree of interaction, I don't think they're relevant.

There are a whole mix of isomers of this substance, but the one of importance is delta, it seems. I believe this is the most potent, and apparently the least likely to cause cancer. Still: don't perceive my interest as a reason to take this drug. I can't think of a worse idea.

I'm pretty sure that it's very similar to benzodiazepines in effect, and I found a paper describing it as "very potent" in this respect, but I seem to have irrepairably lost it.

one of the isomers goes by anothoer name benzene HCH , AKA Gamma BHC, it is a banned insecticide, banned because it bioaccumulates like lindane and the other chlorinated aromatic pesticides.
I don't think it has much activity in humans other than possibly causing cancer due to interaction with the aromatic receptor which I think is the mechanism for TCDD (dioxin) toxicity, though the delta might have more activity at GABA, the commercial preparations of BHC were mixtures of isomers I can't remember seeing much about CNS activity in humans. This stuff is going to depot in fat with a stupid long half life.

fusel oil= concentrated hangover
furfural is metabolised to the alcohol and the acid I think,
V

 

[wungchow]

Here's another article on the toxicity/pharmacology of furan derivatives... the results don't look too promising (fatty changes in the liver)

 

[Hammilton]

Yeah, I came across that last one, but without even an abstract I dunno how useful it'll be

It seems that to find interesting information about lots of depressants, you have to head way back in time, which often means useless research.

Still, in the process of searching out all of these, I've come across a lot that are very interesting and probably useful. Short acting depressants like carisoprodol being my absolute favorite drugs in the world (suboxone, though, rules my life). Fine enough, I guess, since these days my life is devoted to changing diapers, soothing crying and feeding, meaning my days of hands on 'research' is over.

 

[Rectify]

If I had to guess I would say furfural is oxidized from an aledehyde to an acid, but I don't.

Cosmic Bob told me lindane makes your kids stupid. That crap looks like it would too.

 

[Hammilton]

which crap? delta-hexachlorocyclohexane is just another isomer of lindane, so the appearance makes sense...