Limpet_Chicken
Bluelighter
What is the function of kainate receptors?
And are there any allosteric binding sites, and positive/negative modulators of KA receptors known yet?
Activation of presynaptic kainate receptors seems to reduce release of GABA via coupling with CB1 receptors which is interesting, direct agonists are going to be seizure inducing and probably excitotoxic but a positive allosteric modulator might be interesting.
Thoughts?
http://www.nature.com/neuro/journal/v13/n2/abs/nn.2481.html
http://www.ncbi.nlm.nih.gov/pubmed/20303934 This on the other hand seems to imply activation of presynaptic KArs increases GABA release.
And are there any allosteric binding sites, and positive/negative modulators of KA receptors known yet?
Activation of presynaptic kainate receptors seems to reduce release of GABA via coupling with CB1 receptors which is interesting, direct agonists are going to be seizure inducing and probably excitotoxic but a positive allosteric modulator might be interesting.
Thoughts?
http://www.nature.com/neuro/journal/v13/n2/abs/nn.2481.html
http://www.ncbi.nlm.nih.gov/pubmed/20303934 This on the other hand seems to imply activation of presynaptic KArs increases GABA release.
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