Bupe Freebase buprenorphine, suboxone, subutex

[rplate81]

Obvious dumb question/theory

I have no knowledge of how to make a freebase of any type of substance. I do understand the basic process of turning cocaine into crack, but I have no experience in actually doing it.

I haven't really heard of any other drugs that have been freebased. My question is what is it that makes a certain substance to be made into freebase?? I wouldn't think that Suboxone strips could be freebased, but possibly the pills??

Here is a link that I found, although it was hard for me to follow so I didn't read the whole thing.

https://patents.google.com/patent/CA2977732A1/en

 

[Pickledlemons]

No idea. I've been on suboxone for idk a long ass time, a decade give or take. The thought never crossed my mind. I had a friend who's been to jail and said they used to insufflate it. That sounded weird to me. I gave him some to do it, since he said it was like a nostalgic thing. I do not believe I partook myself though. I mean it works just fine enough sublingually, I dunno why I would insufflate it, unless there was some huge increase in bioavaliability, and going off memory, I believe there was less ( though don't quote me on that). And especially since you know, doing that with tablets is usually a bad idea because of all the wax and binders and who knows what else (unless its hydrophone, then its okay, or maybe that was just because I liked it )

But yeah, freebasing, I, uh, I dunno, that sounds, probably complicated and do you have reason to believe it would be more effective? Do you just like inhaling your drugs and thats the reason?

 

[TheFunkeeJunkee]

A freebase is the “base” form of a molecule. In this form, the nitrogen atom is neutral and has a lone pair of electrons, which allows the molecule to act as a base by accepting a proton. This combination of a nitrogen with a lone pair of electrons is called an amine. In contrast, a salt is formed when the same molecule reacts with an acid. The acid donates a proton (H⁺) to the nitrogen, giving it a positive charge. The negatively charged part of the acid, such as chloride (Cl⁻) from hydrochloric acid is then attracted to the positively charged nitrogen, forming an ionic bond. This ionic bond is what makes the molecule a salt.

Using cocaine as an example, cocaine freebase contains a neutral nitrogen. When it reacts with hydrochloric acid, the nitrogen accepts a proton and becomes positively charged, while the chloride ion, which is negatively charged, forms an ionic bond with it. The result is cocaine hydrochloride, the salt form of the molecule.

The process can be reversed to regenerate the freebase using an acid-base reaction. A base such as sodium bicarbonate, reacts with cocaine hydrochloride and removes the proton from the nitrogen, returning it to its neutral state. Once the nitrogen is neutral again, the ionic bond with chloride breaks, producing cocaine freebase.

These two reactions apply to basically any molecule with an amine, including buperenorphine. While in principle you could perform an acid-base reaction with suboxone or subutex, the presence of other stuff such as polymers, stabilisers and dyes would result in a final product that's not safe for recreational use. Acids and bases don't just charge nitrogens, they can also break or form bonds with other atoms.

As you know, cocaine is converted to a freebase because as a base it's chemical properties allow it to be vaporized. As the hydrochloride salt, cocaine decomposes before it's vaporized. This isn't a universal rule however. Some bases like amphetamine are volatile oily liquids that are difficult to handle and some salts are actually preferable for vaporising such as methamphetamine.

There's very little reason to think buperenorphine base will have desirable properties compared to buperenorphine hydrochloride. Ultimately whether a drug is a salt or a base, its pharmacodynamics (the ways in which a drug interacts with receptors and enzymes) remains largely the same.

 

[Snacktion_Jackson]

Freebasing...bupe...I mean no offense, I just never thought I'd see those words together. I may be dead wrong and you may be onto something, but it seems antithetical. If you get your rocks off man, lemme' know!

 

[Lowrider110]

Have been on subs since 2008 and my life has been great since then, good the way it is, strips or pills

 

[4DQSAR]

The melting point of buprenorphine freebase is generally reported to be in the range of 217°C to 218°C.

In other words, too high. It's still got that bare phenolic -OH. Yes, I bet you COULD acetylate it, but I wouldn't. Because who knows if 3-acetyl norbuprenorphine is toxic. The only reason plain norbuprenorphine doesn't kill users is that it's actively removed by the same ABC-binding cassette as loperamide and we have all heard what happens if you overwhelm that transport. To whit, you die.

But it's your body so it's your choice. I'm just one person offering one opinion.