That was simply my understanding of the current consensus on SSRI's method of action, which, as you said, is no more than an educated guess. However, we do know that LSD, mescaline, and psilocybin, as well as most other serotonergic psychedelics, act upon the serotonin 5HT2A receptors as a very powerful antagonist. This action is responsible for most if not all the hallucinogenic effects of psychedelics, and overall these psychedelics essentially cut off communication between certain areas in the brain, and the experience of tripping is literally losing those connections and regrowing new ones in their place. And I wholeheartedly agree that it varies greatly from person to person because everyone has a totally unique body chemistry. Hell I have severe ADHD and because of that both adderall and coffee help me go to sleep, when most people get the opposite effects from them. However, I had reason to believe I would get a diminished effect from the LSD in this case because I had tried sertraline (zoloft) before the fluvoxamine for my OCD, and whilst on 100mg a day of zoloft I tried tripping on an eighth of psilocybin mushrooms and I felt very little effects, certainly no visuals. It felt more like I ate at the very most one gram of weak mushrooms, not an eighth of one of the most potent strains out there. On the Fluvoxamine and LSD, though, I ate 3 hits of white on white (just plain little white squares of paper), and I tripped FACE. It took me a full 28 hours after dosing to come down off my trip enough to fall asleep (I dropped around 1 a.m. so I was awake for approximately 60 hours straight with no sleep. I had a stronger than normal trip on 3 hits of LSD, and yet hardly tripped at all off an eighth of potent mushrooms whilst on 100mg of zoloft a day. Everyone is different and there's no way to know until you try it. Thanks for the input though guys.
