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Fluorenol (The wakefulness enhancer)

SkyblueMolly

SkyblueMolly

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Forever lost within the 99 percent
I was interested in Fluorenol for a while, but no human has tried it before. Only lab rats. In rats, it causes more wakefulness than modafinil. Has anyone tried it? Does it work in humans? If so, then this would make modafinil seem wimpy. It also causes less dependence than modafinil in lab rats.
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You started a Big & Dandy for something where you think "no human has tried it before"?

Never heard of it personally & I doubt you'll get a great many with information on this. But you seem to know something about this so why don't you start us off and post links, or even details, of the rat research you refer to.
 
Firstly - only staff centralizes threads, small & handy if departing from the initial theory stage and big & dandy if it is actually available to some and being tried and if there is more than a few meager posts on it.

Secondly - this is the wrong forum for a wakefulness enhancer.
Let it be discussed theoretically in NSP first. It may be interesting to first know if the mechanism of action is better understood than that of modafinil. Does it directly increase monoamine levels via vmats or is there some weird orexin action yet to be elucidated? (Oh wiki says it is a DARI)

(Thirdly, why is it called fluorenol if it does not contain any fluorines? Ohh found it - it is a fluorene derivative which is called that way because: " It has a violet fluorescence, hence its name")

PD >> NSP
 
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I sort of doubt the activity, but ya never know.

Someone posted an amphetamine analogue with this backbone in the drawing thread, that one was extremely interesting to me because it makes takes the diphenyl motif that's so potent and makes it rigid.
 
Is the SAR / pharmacophore the same ballpark as the pipradrol et al.?
 
Definitely interested in this especially if it's stronger than modafinil. Modafinil didn't do much for me except make my eyes less heavy and make me yawn less lol
 
It's less potent, and not very druglike (poorly absorbed, metabolised). You'd need a prodrug to deliver it effectively.
 
I forgot they discuss the problems of delivery because of some delay in absorption. Maybe you chem majors might know what might be wrong with nasal or sublingual delivery. Two of my faves except with pramiracetam [this is not a `get high drug' damn it] This place is sometimes like a jr. high dance chaperone…. "Betty! Tommy! That's too close no grinding!"

Ron
 
Anyone tried it yet? [edit: nope] This is very exciting.
 
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I have tried both fluorenone and fluorenol and fluorenone exhibited some excitogenic effects more so. However it must be noted that I take provigil, despite this I do not trust these compounds.

Having tried multiple doses of each fluorenone provided highest effects which were not euphoric whatsoever(unlike Modafinil) , I am purposely neglecting dosage data because I DO NOT TRUST THESE. I exhibited urinary spasm and cramping of the groin with concomitant usage of moda/fluorenone.

Now many of you may say, oh wait well hydrafinil is fluorenol so it is fine, but I must inform you that fluorenol is most likely rapidly oxidized to the ketone fluorenone, despite the parent data being on fluorenol(if someone could link this patent, but I believe it was only in vitro and not in rats, if it was indeed tested in rats then fluorenone is the active compound). Also this ring system is rapidly apt to aromatic epoxidation, leading to reactive oxygen species.

If you wanted to guess how this works I would assume something related to hydrophobic forces and consciousness(see opposite of anathetics and their mechanism, read hammeroff).

Please stay away from this drug, the spiralling nature of failed trials on drugs by pharm companies and their revival can do more harm than good at times(see the ritalin-mdpv-desoxypiperadol case).

Best and warnings.
Zedsdead
 
Neat structure, indeed.

The ketone is like a neat spaceship from above... The starcraft from StarWars 7?

Although I like more that carboline I found recently:

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I ended up getting Hydrafinil(fluorenol). It's not much to write home about, but it's pretty wakefulness enhancing. Like a cleaner(though subtler), and more wakefulness enhancing version of modafinil. It also increased mood in a subtle way and also made things look clearer. It's mostly subtle though, and I don't use it often, but now I'm less tired and far less sleepy during the daytime than I would sometimes get. It's mostly subtle, and not much different at all, but it helps if used correctly. I found out how I could use it to maximize daytime wakefulness while maximizing sleep efficiency. If taken in the afternoon around 6pm, I could sleep at 10pm or 11:30pm and wake up 6 to 8 hours later(around 4am to 6am. Depends partially on sleep debt verses an excess of sleep reserve) feeling oddly refreshed. Higher sleep efficiency?
The duration of Hydrafinil is 3 hours to 5 hours.
 
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recommend avoid fluorenol

Obtained a sample of fluorenol and tried it in hopes that it would be more effective, less expensive, and less hepatotoxic than the isomers and prodrug of modafinil. Bought into the hype. Wish I hadn't. Recommend sticking with molecules more closely associated with modafinil. They are much better understood, proven to work, and safer.

Used various doses of fluorenol, ranging from a couple hundred milligrams to a couple grams. Wakefulness did not improve. Generally felt worse -- tired, fatigued, worn out. Memory registration and long-term recall both tanked. Also had several episodes of sleep walking (likely a drug-drug interaction). In recordings, appeared awake, performed complex tasks, and had intelligible conversations.

During the fluorenol trial period, did not use caffeine (not even decaf). Did not use modafinil (or closely related substances). Did use baclofen, citalopram, and zolpidem. Baclofen use was minimal. Toward end of citalopram dosing cycle, occasionally have SSRI withdrawal symptoms, which tend to worsen with increased sleep debt. They did not significantly change during the trial period.

Daily zolpidem use was consistent with usage prior to the trial period. Although zolpidem is known to cause complex sleep-related behaviors, the only reports of any unusual nighttime activities was during the trial period. Prior to that, had no unintended effects during years of use. The sleep-walking was likely induced by zolpidem after cognitive function was first impaired by fluorenol.

After the trial period, have tried several isolated doses of fluorenol with similar effects. Each time, wakefulness did not improve, felt generally fatigued, and memory was impaired. Sleep walking did not recur. Perhaps the permissive effect of fluorenol on zolpidem does not occur until after several days of continuous use. Improved sleep duration and quality does not mitigate the negative effects of fluorenol.
 
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