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"Fluoprazolam" Iupac name:(Z)6-(2-fluorophenyl)-2-((4-methylpiperazin-1-yl)methylene)-8-nitro-2,4-dihydro-1H-benzo[f]imidazo[1,2-a][1,4]diazepin-1-one

pcplease

pcplease

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246
Structure given-


Fluoprazolam.jpg


Saw some claim that this is available. How it might act is designed me. The name led me to believe it was Alprazolam's Cl swapped with Fl as was Bromazolam, and I suspect that is their intention. It is from one of the most reputable CN vendors.


Fluoprazolam marketed under many brand names is a benzodiazepine medication. It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It is licensed and marketed for the short-term treatment of moderately-severe insomnia.:
The dose of Fluoprazolam for insomnia is usually 1 mg but can be increased to 2 mg if necessary. In the elderly a lower dose is recommended due to more pronounced effects and a significant impairment of standing up to 11 hours after dosing of 1 mg of Fluoprazolam.:
 
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Lose the double bond alpha to the piperazine ring, and you might be on to something more.
 
helium-4 said:
Where are you finding this info, I can't find shit on it on Google.
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That info is the product description on their site. i have no idea how it'd metabolize, other than into something like flunitrazolam. Really hope someone has some insight even if i am not particularly interested in a long hypnotic bzd.
 

Compound 31 to be specific.

But here's the thing - it was tested in vivo using lab mice so someone evidently put a lot of money into this research but I can find no human trials.

As I constantly remind people, until www.alltrials.net makes disclosure of all human studies mandatory, we don't know if there even WERE human trials. But in the end and for whatever reasons, the new sub-class of benzodiazepines were never developed into medicines. It was the late 1970s, a time when older benzodiazepines were at the end of their patent-protection period so it would be good commercial sense to developing new (patentable) medicines.

So what I would ask is why this class was never seen anywhere on the planet?

I'm not sure I would want to be first-into-man on this one.
 
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I was hoping you'd respond and greatly appreciate your insight and perspective on this popping up.

Loprazolam seems to have some fans. I expect this one will too, with the popularity of flubromazolam. I would very rarely have reason to use such a long acting hypnotic, myself. Few compare to the proven safety/reliability diazepam, lorazepam, maybe clonazepam (at minimum for long-term treatment of epilepsy)


Japan's approach to benzos seems smart and effective. Take Mexazolam- metabolites Delorazepam and Ativan. To be taken 3x/day. Lorazepam throughout the day while delorazepam builds up until it's not needed. Very low recreational value, better antiepileptic than diazepam and lower overall reduction of anxiety.
 
pcplease said:
Loprazolam seems to have some fans. I expect this one will too, with the popularity of flubromazolam. I would very rarely have reason to use such a long acting hypnotic, myself. Few compare to the proven safety/reliability diazepam, lorazepam, maybe clonazepam (at minimum for long-term treatment of epilepsy)
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Ah - shows I'm too close to see the broader picture.

I didn't know loprazolam was already in use.
 
I have never heard of it either and it's apparently approved for use in North America, and Germany. May never have been marketed much, or years ago.
 
I cannot imagine it being synthetically simple and I've watched new medications arrive that have no obvious clinical advantage and then wathed them disappear. Quite often a medicine will fail if it's trying to solve a problem that doesn't exist.

What doctor prescribes something which they have no experience of when it's no better than the medication the doctor has experience of prescribing?
 
I wish/wonder if other labs will make loprazolam as they did alprazolam. Clonazolam was so popular.

Not to derail, but perhaps that reason alone is why I was so surprised to hear about Mexazolam with how perfect it sounds on paper and I'm sure in practice. Reducing dependence by starting from getting rid of near/all the sedative and euphoric effects of BZD's, until they are imperceptible, easier to taper and/or to finally do the most important step, not taking the next one. etc
 
I'm awaiting the reports, nothing on reddit yet except a guy trying to make a solution combining it with something else. 3 months from now: flurapperzlm nt wrkin.
 
gabacool said:
I'm awaiting the reports, nothing on reddit yet except a guy trying to make a solution combining it with something else. 3 months from now: flurapperzlm nt wrkin.
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Well medically benzodiazepines are often dissolved in propylene glycol (not ethylene glycol - well known toxic antifreeze). Compounding is an entire speciazlization in it's own right. It's not glamerous but it does require a specific skill-set. Someone sent me a photograph of the test chambers used by one large compounding company where new medicines were placed at 'climatic' extremes so in three months they could see how a medicine would likely endure for decades.

It was very impressive - I would like being locked inside of one. They even LOOKED like carpted torture chambers.
 
4DQSAR said:
Well medically benzodiazepines are often dissolved in propylene glycol (not ethylene glycol - well known toxic antifreeze). Compounding is an entire speciazlization in it's own right. It's not glamerous but it does require a specific skill-set. Someone sent me a photograph of the test chambers used by one large compounding company where new medicines were placed at 'climatic' extremes so in three months they could see how a medicine would likely endure for decades.

It was very impressive - I would like being locked inside of one. They even LOOKED like carpted torture chambers.
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Back when you could just order grams of etiz powder from other redditors, I would only and ever use PG for benzo powders. AFAIK if it's a pure benzo powder, it might shade your solution a little bit there should be no powder/particulate left in that solution. With pure Etizolam you would sometimes get white specks that just needed more agitation, time and heat to take to the solution.

A vendor just bumped their dosage from 1mg a pill to 4mg a pill so that's in the weaker direction rather than people saying it could be stronger.

Edit: How could I forget to make a joke about the poor asian dudes plight then taking said chemicals and puting them into a few mls of solution for my torture chamber.
 
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1mg or less may put one right back to bed if taken during the morning, especially with lingering benzos in one's system. Very forced headache-y need to close one's eyes. That first tiredness lasted 12+hrs , albeit anxiolytic

Taken at night, if the hypnotic effects are not felt at a full 4mg can be easy to get caught up in feeling good/eating. Each time I have taken 3-4mg immediately before trying to close my eyes, I have fallen asleep, but wake up pretty wide awake after 5-7hrs. Not groggy like bromazolam, flubromazolam. Perhaps still under the influence of lingering effects, perhaps it is from a sharper rebound. Calm morning following at 2mg, requiring a little extra stronger coffee than usual at 3-4mg. Doubling to ~8mg before bed did not offer much more benefit, just a little extra grogginess than 4mg. Still woke up well before my alarm, and am more tired than I'd like to be. After 3-4hrs sleep woke up to eat (more than I should've) and quickly return to bed.

My trials with this benzo alone are probably finished. I suspect it would stop a true panic attack at 1mg or less because of how forcably "down" the compound feels. Greater drop in blood pressure and heart rate, considerably more dilated pupils and than other benzos at comparable doses.

This will have great use as a sleep aid with less potential to sleep through the alarm clock(s) the next day. Flubrotiz, f-Lam, f-Pam, brom...etc.

Very potent hypnotic, i assume skewed by bromazolam's long-popularity, strong sedative properties and more rush/punch on onset. It does act pretty quickly with sublingual dosing a solution, much quicker than putting a bitter press under a tongue and hoping it crosses the blood-brain barrier without aid of PG/EToH.


*all subjective effects, BP/HR lead me to assume this chem potentiates CNS depressants more considerably at equivalent doses. Pure speculation, but do not become a statistic.*
 
BTW I've noted that for whatever reasons, the Japanese Pharmacopoeia tends towards both prodrugs or longer-acting benzodiazepines.

Now maybe the theory is that as it was the short and moderate-acting barbiturates that were the ones typically resold illegally, their logic is to only use benzodiazepines that are less 'desirable'.

BTW I've had a couple of people mention that phenobarbitone is effective in reducing the AWS of benzodiazepines (and are very cheap) but I would only touch phenobarbitone if the alternative was seizures. It's no fun (for most people) but I suggest that it's capacity to form a physical dependence is simply huge.
 
I do appreciate/respect that different approach. Especially with things like Mexazolam, constant Ativan throughout the day as delorazepam builds up and presumably after a week or two, one would feel "baseline"/sober throughout the day and night.

I've read the reports that the hypnotics are STRONG, long hypnotics- however I'm not sure if they were around when flubromazepam and flubromazolam became available.

I needed some when being detoxed from high dose (XXmg) diclazepam and had been drinking unbelievable amounts to try to deal with it. I don't know how much Ativan and Valium I had been hit with at that point but the second the phenobarbital hit was arguably the most euphoric/relieving feeling I have ever experienced.

At one point as a borderline adult/around 18 I found a 1000ct bottle, and took it pretty often to make a few beers go further, sleep easier etc. We had all been on Erowid for 4+yrs- filled with horror stories- so nobody else would touch them. Not sure I could say it had negative effects, or if negative psychedelic/mdxx experiences had those effects, etc. All I can attest is that yes, with 1000 laying around "working from home", it is very easy to just keep taking them.
 
Diclazepam is the very worst devil. Would you believe that the original intent was to provide a sort of methadone for benzodiazepines so people could get off the roller-coaster, stabalize and reduce?

I don't think anyone expected it to ever be consumed 'for fun'.
 
I was between a rock and a hard place - previously taking F-Pam, somewhere along the line a gram of clonazolam was consumed in a couple months and only having access to diclaz.

I tried it again years later and I wouldn't call it particularly fun, or enjoyable. I was however eyeballing powder which greatly increases any chance of "fun" (and chance of disaster).

I still believe it has potential, but IME Mexazolam has far, far lesser abuse potential. After a few days I stopped feeling enjoyable moments like the onset of my morning 0.25mg phenazolam at T+90min. Trialed a couple other benzos to similar result. Lorazepam alone has had that effect on me, and im ashamed to say that i am not super familiar with delorazepam's activity other than LONG, and by weight strong. I assume metabolizes into other actives unlike lorazepam being excreted unchanged through kidneys
 
4DQSAR said:

Compound 31 to be specific.

But here's the thing - it was tested in vivo using lab mice so someone evidently put a lot of money into this research but I can find no human trials.

As I constantly remind people, until www.alltrials.net makes disclosure of all human studies mandatory, we don't know if there even WERE human trials. But in the end and for whatever reasons, the new sub-class of benzodiazepines were never developed into medicines. It was the late 1970s, a time when older benzodiazepines were at the end of their patent-protection period so it would be good commercial sense to developing new (patentable) medicines.

So what I would ask is why this class was never seen anywhere on the planet?

I'm not sure I would want to be first-into-man on this one.
Click to expand...

Solid logic as always. I would echo that.
 
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