Flephedrone

[Barkuti]

Hello everyone,

It seems some known producer of RC's will soon be able to start issuing orders of this compound I've never heard of, chemical name (as listed):

2-Methylamino-1-p-fluorophenyl-propan-1-one

Chemical structure seems to be almost like Mephedrone, a fluoro instead of a methyl group there.
I'm not a chemist, so I won't make any comments on this subject.

Just wanted to start a thread on this, still I've not laid my hands upon mephedrone (very very soon), and now this shows up... interesting.
I'll be looking for comments and first investigations over it if anyone happens to lay his/her hands upon.


Cheers

 

[sixpartseven]

ADD, I dont know if this is your guys' thing, so sorry if its not. Its not ours either though.

Shifting OD -------> ADD

 

[mad_scientist]

"Flephedrone" ay...who comes up with these names!

Well seeing as 4-fluoroamphetamine and 4-fluoromethamphetamine have both appeared on the market its not much of a surprise to see 4-fluoromethcathinone come along. It will be fun enough I'm sure, and legal most places outside of the USA...

 

[Canis aureus]

Well, when those bk analogs seem to appear here and there (mostly there though), why wouldn't anyone produce bk-TMA???

That would (could) be interesting product....

 

[fastandbulbous]

^ bk-TMA is a primary amine & a keto group in one molecule. Like all beta-keto unsubstituted amine amphetamines, it doesn't take much to get it to dimerize into a pyrazine derivative, which is inactive

 

[Barkuti]

Compared to 4-fluoro-amph

Hello,

I wonder how will that feel compared to 4-fluoro-amphetamine.
I've not tried 4-FA yet either, reports are positive, but duration seems a bit on the hardcore side. Maybe 4-fluoro-methcathinone will be more forgiving in this respect.
Just speculating of course.


Cheers

 

[Coolio]

I bet this stuff is good.

 

[Riemann Zeta]

I really wonder what bk-TMA is like? I agree F&B, it wouldn't be very stable. One could phthalate it (said aloud, that sounds hilarious) and get a pro-drug form (is there anything toxic about phthalic acid that would be problematic) that is nice and stable. Such a thing has been done with the bizarre (and horribly named) phtalimidopropiophenone. If you wanted a natural protecting group, think about using an N-lysine, a la Vvyyanse.


I'm not sure about flephedrone. First of all, that is a really strange name, I wonder if it will catch on. How about PFMC as a name? I never been lucky enough to encounter 4-fluoroamphetamine, so I can't speak to the effects of it, or of 4-fluorocathinone. I also think that bk-TMA (or TMC, as it would be called) would likely be at least somewhat active as a real psychedelic, not simply as another cathinone-like stimulant and that using the pure (R)-enantiomer might help cut the side effects, especially after that ketone is reduced.

 

[fastandbulbous]

One could phthalate it (said aloud, that sounds hilarious)

Thjere's a rhythm to saying it without sounding like a tellytubbie on acid

How about PFMC as a name?

Makes it sound like the political front of some terrorist organization. There are enough compounds with an alphabet soup of letters already. If you're after precise identifications of these compounds, learn the IUPAC rules on organic chermistry nomenclature. Best is a snazzy contraction of the commonly used name (always thought amphetamine was a brilliant, snazzy name )

Just a suggestion!

 

[Riemann Zeta]

Amphetamine was a brilliant name (alpha-methylphenethylamine), especially when it could have been called phenylisopropylamine (phenpromine?).

Shitty name aside, any thoughts on (R)-TMC (bk-TMA, with a protecting group)?

 

[fastandbulbous]

Possibly, suppose it's got to be the right group as I remember reading that N-acetylmescaline was inactive. Don't know what to make of a phthalimido derivastive of a primary amine though (allows one less step if using the Gabriel synthesis method, so might have a virtue of easier purification - who knows!). Only concern is that I think Thalidomide was a phthalimido derivative, so they might be quite ugly compounds, messing with development & genetics

 

[Barkuti]

Name that compound...

Hi,

April fool's day, someone decided to spice up the forum colour scheme...

Wow, came here to discuss about parafluoromethcatinone, what's up with bk-TMA? Reading Shulgin's comments TMA isn't a very enjoyable compound, with a low power/mass ratio, and produces nausea (referring to this when speaking about the (R) enantiomer Riemann?). In which way would TMC (or TMMC) be preferable to TMA?
What's that TMC protective group for in this case? Is TMC very unstable in itself? Wouldn't the metabolization rate (cleaving) of the molecule limit in some noticeable way the release of TMC in the brain?

Sorry for such a bunch of questions, I know not much more than jackshit about chemistry.

Back on topic, I'm wondering if there's any previous research on 4-FMC. Pioneering here?


Cheers

 

[hamhurricane]

I would be surprised if this gained any level of popularity. first of all the parent compound 4-FMP is relativly unpopular despite its availability, and unscheduled nature. the dose is high, and it cant be insufflated. Most people cite price as the prohibitive factor, but price does not keep anyone away from methylone...i digress.

My single 70mg 4-fmp assay was quite odd, it produced an emotional clarity unparalleled by any other stimulant i have taken. i also felt a strange melancholy/wistful/nostalgia that was quite moving, it made me cry. MDMA has never produced clarity for me (more like a narcissogen than a empathogen) in fact i found 4-FMP to be "too therapeutic" for recreational use. since that 70mg experience, i have only taken threshold amounts of it (5-10mg) sublingually for its mild stimulant effects.

whats the point of a bk-analog, when the amphetamine is still chugging, it will probably make it more expensive and even less potent. but that dosent mean im not curious, if you assay it be sure to report back here and tell us how it goes!

 

[djfriendly]

4FA (man do I hate that "4FMP" name, it's a nomenclature which I can only hope will someday disappear) has an extremely long duration, which I believe is one reason for its relative unpopularity. A cathinone analog might provide desired effects within a shorter time frame.

 

[neuwelt]

How long is the duration of 4-FA/4-FMP? From what I've heard it doesn't seem especially extreme, 12 hours or so? Seems like non-alcoholic beer compared to desoxypipradrol.

On-topic: If my memory serves me well 4-fluoro-methcathinone has been bioassayed by members of the Hive/Hyperlab and was found to be quite inactive requiring very large dosages for any stimulant activity at all. In conclusion, not worth it. However my memory have failed before but this information should be possible to find with a few searches. I will return if I find anything.

 

[Barkuti]

Cathinones are weird...

Hello,

Yep, price isn't something that usually stops people from getting the drugs they want; after all, most of the time it has more to do with the recreational potential of the drug than with manufacturing and/or distribution costs.

If the effective duration of 4-FA is around 12 hours... Hell, a lot of people I've speaken with get annoyed with plain old amphetamine in this respect... damn coke suckers.

I really wonder what could be the duration for 4-FMC, probably around the likes of meth. Evaluating its potency is far beyond my skill level atm; I doubt it will be much less potent than 4-MMC... and that's not exactly a compliment since 4-MMC is low in potency.

I don't see me having access to 4-FMC soon, for now I'll be awaiting for someone to stumble upon the substance, try it, and report. I will probably order a sample after some weeks if this gets stagnant. I'm very curious... %)

BTW, yesterday I received a strange postal package: smelly 4-MMC.
Preliminary tests have been greeeat... I'll have to add some report somewhere. :D


Cheers everyone

 

[Smyth]

I was speaking to haribo1 about "Mephedrone" the other day since I thought it looked like an okay compound.

He told me that the p-methyl group is readily oxidized so this compound will have a short half-life in the body.

Can other people confirm that this is infact the case? I dont necessarily doubt him, it's just that my knowledge of biochemistry and enzymatic transformations is not great enough to tell to what extent this would occur in vivo.

I think he said something to me about people who tried it noticed that it has a short duration of action. I know that MDPV certainly has a short duration of action, waaaaayyyy shorter than MDMA even though Meltzer states in his recent paper that they last for a full 8 hours (in rats).

 

[Refluxer]

Mephedrone is indeed a short acting compound compared to amphetamine and many others.

 

[Smyth]

BTW, yesterday I received a strange postal package: smelly 4-MMC.
Preliminary tests have been greeeat... I'll have to add some report somewhere.

4MMC = p-methyl-methcathinone = "mephedrone", correct?
Well, it is gonna be interesting to see what the popularity of this is like and how it compares with the p-fluoro analog.

Mephedrone is indeed a short acting compound compared to amphetamine and many others.

Obviously it is short-acting compared to amphetamine, but so are ALL of the beta-keto series of compounds.
My question was if there is something about the p-methyl group that makes it especially vulnerable to oxidative degradation. If so, then one could think about consuming p-methyl-amphetamine without worrying about it lasting for days. That's included in some of Rothmans recent papers alongside PAL-287. It was called "PAL-313" infact and is less dopaminergic than amphetamine, but more 5-HTergic, which was shown to make it LESS abusable.

BTW, in the same review article, Rothman states that diethylpropion lacking an ethyl (= ethylpropion) behaved as a NE reuptake inhibitor (but not as a releaser).

 

[Smyth]

Ok, looking back on this thread it doesnt look like PFMC will be very tasty material. The p-F-amphetamine looks all right though if you want some "clinical" speed which feels less "recreational" than plain amphet.

I'd still like to read some "mephedrone" trip reports though.

Maybe Chloridrone or Bromidrone are doable though? Since these arent strictly amphetamines, I wonder if they would still be neurotoxic? I mean plain p-bromo-amphetamine was used for a while as an antidepressant.

See for example Sibutramine, and I think chlorphentermine also has a history of being used on humans.

These are only ideas btw, just throwing in my 2 pence