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FDA OKs Zohydro, 1st Hydrocodone-Only Painkiller

Fire&Water said:
No, its not that...no form of XR opioids will break down or dissolve by the time they reach my small intestines.
They might with the aid of something acidic etc...but F that.

Dont need euphoria, need pain relief.
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Methadone dosed every eight hours was literally a god send for me and pain relief.. it needs to be dosed this frequently as it analgesic affects only last that long even though its other effects may last longer. Something to explore and consider.
 
MoreFeens4Morphine said:
I heard the FDA shot this down months ago? Well, who gives a damn. Time to get me some! Is this the same form of hydrocodone (hydrocodone polistyrex) that they put in Tussionex?
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yeah I thought I read it got shut down too but that's the legal system for you

"it's NOT ok"

*millions of dollars and lawyer fees later*

"ok but it's Schedule II!"
 
This might have been a compromise, back room deal... They let zohydro on the market, and make it harder to get vicodin...

Btw, does anyone know when this shit will be actually available? I'd like to try it for my chronic pain cause hydro has always worked better than oxy at high doses, but that's unsafe CWE or not imo
 
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neversickanymore said:
Methadone dosed every eight hours was literally a god send for me and pain relief.. it needs to be dosed this frequently as it analgesic affects only last that long even though its other effects may last longer. Something to explore and consider.
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I was on methadone prescribed by a pain specialist for about 7-8 months...the side effects even after that short a time were so extreme I couldnt wait to flush the extra.
 
weekend addiction said:
If I ever get chronic pain this is what I would probably want.
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No you wouldn't the anti-abuse technology is going to be like all the other anti-abuse ER opiate meds right now... Just like you can't really abuse the OP (Oxy) or that Morphine ER (with the beads inside the capsule; like adderall XR)... So good luck trying to get high off this stuff, anyways what mg's are these Zohydros going to come in??
 
Can't you just take extra to compensate for anti-abuse shit? It should just last a lot longer. I can't wait to try some!
 
Please Health Canada, pick this one up, Codeine Contins are ok only if you take 2 200mg ones for most people. And we already have hydrocodone only pills, hell, it's all we have! 5mg Hycodans which doctors rarely ever prescribe/knows it exists ! I loved codeine back then in the way it is most often dispensed, as Empracets 30 (300mg apap/30mg codeine, 60's very rarely being prescribed, docs will just script you more E30's if you need more codeine which is retarded). Plus a lot of people are allergic to codeine or get half allergic and get a lot of itching from it, while it is not the case with hydrocodone! Sure don't accept oxymorphone, there was never any news after you were reviewing it in 2009, but if we have Hydromorph Contins thrown at everyone, I think Hydrocodone Contins would make much more sense!

juno nightmare said:
hmm looks like the controlled release technology is called SODAS. lol. this is the same tech used for focalin, the er methylphenidate and for avinza the newish er morphine. never had either of these before.

the tech uses tiny orbs that contain a drug surrounded by layers of control release polymers. It sounds like these could be cut open and crushed into a powder similar to the controlled release adderall with the tiny orbs inside. wonder if they will put something in there to make the mixture turn to gel or something when mixed with water to make snorting and IVin difficult. anyone who understands these systems better wanna chime in and lets us know what the deals is with these.

frankly i hope they wont be super easily abuse able. now before you throw your virtual rotten fruit and vegetables my way hear me out. hydrocodone has such a bad reputation IMO because its mixed with tylenol so it damages the liver if you take too much, if you mix with alcohol or other meds, or if you just take it for a long time. for me personally the hydrocodone mixtures currently available make me so nauseous that taking more than one or two vicodin is almost impossible unless i do a CWE and that to me defeats the purpose of using it as a medication when i need it for legit pain.

It actually made my abuse my scripts when i got em cause i couldnt take them and function normally. if i needed to go to school or work i would be too nauseous to do that. the only way to mediate this was to eat a large meal right before dosing, which is not always possible especially since they are indicated for dosing every 4-6 hrs. and for anyone who is a large person like me or naturally opiate tolerant it is really ever 2 hrs or less. this stuff could be exactly what people like me need for moderate pain.

this stuff could actually be safer even if abused cause of the lack of tylenol. most deaths from vicodin and related formulations are from the tylenol and people combining alcohol with it.
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Ever thought of asking your doc for Vicoprofen ? It is my understanding you guys have that. Ibu most likely would not make you nauseous like that, maybe get one hell of a stomach-ache if you are like me though.
 
this is a great idea. APAP is so much worse for the body then any opiate
 
Can't wait to get my hands on some of these to test out. I bet these mixed with some regular 10s would hit the spot.
 
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Fire&Water said:
I was on methadone prescribed by a pain specialist for about 7-8 months...the side effects even after that short a time were so extreme I couldnt wait to flush the extra.
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Ever heard of methylnaltrexone, or brand name Relistor? Intended you only get the central analgesic effects, but it will block all or most PNS MU opioid agonism (dependent on dose).

It was developed to be co-administered with opioids to cut side effects.
 
The approval of this drug was a big f/u to the makers of opana and OxyContin. Supposedly when this drug comes out it will be without the SODAS technology, in other words there is nothing to deter abuse. Apparently the need for a hydrocodone only product superseded the need for anti abuse features. The company was somehow able to convince (bribe) the FDA. Additionally, zohydro is in capsule form, which means less fillers and high purity hydrocodone. Investing in zogenix looks like $$$. Unfortunately it's going to create a whole new generation of op addicts.
 
Fire&Water said:
story continues: http://www.medpagetoday.com/PainManagement/PainManagement/42493

Right after "Zohydro" was passed for approval today, FDA wants to re-schedule Hydrocodone from schedule III to schedule II.
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they need this so bad. doctors never tell patients how bad Acetaminophen is for them but they sure as fuck will always throw in the "hydrocodone is addictive". however, they will not tell you "the amount of APAP I am prescribing you will tear your liver apart"
 
Groundhogdayagain said:
The approval of this drug was a big f/u to the makers of opana and OxyContin. Supposedly when this drug comes out it will be without the SODAS technology, in other words there is nothing to deter abuse. Apparently the need for a hydrocodone only product superseded the need for anti abuse features. The company was somehow able to convince (bribe) the FDA. Additionally, zohydro is in capsule form, which means less fillers and high purity hydrocodone. Investing in zogenix looks like $$$. Unfortunately it's going to create a whole new generation of op addicts.
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you cant shoot hydrocodone so the risk of serious abuse is much lower than say, oxymorphone or oxycodone.
 
I want these so bad. I hate taking in so much acetaminophen everyday :(.
 
MemphisX3 said:
you cant shoot hydrocodone so the risk of serious abuse is much lower than say, oxymorphone or oxycodone.
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True u can't slam hydro, however, what is its bioavailability? I think your statement has more relevance toward oxymorphone, given its low oral and intranasal bioavailability. With you on that.

I totally agree with the toxicity of apap, that stuff is bad news for the liver and kidneys.
 
Does anyone know how long it usually takes for a med to go from approval to the pharmacy?
 
The prescribing info is on the manufacturers web site. It looks like good news for chronic pain sufferers who would rather not have the apap.

For people that would manipulate the medicine, the sheet explicitly warns not to chew or crush, and not to drink as alcohol can raise concentrations up to 40%.

Edit: I don't know when this will be out though. For pain mgmt. people, asking for the lowest apap avail (300mg in xodol) might be your best bet.
 
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