asecin
Bluelighter
- Joined
- Apr 13, 2005
- Messages
- 1,725
if you cant afford ketamine, try Yuejo https://www.nature.com/articles/srep13573
The analouge methoxetamine is extremely similar. It was actually designed by a former bluelighter. It was designed to be a physically safer version of the drug in relation to bladder damage. I'm sure it hasn't been studied in relation to depression. From my anecdotal experience it dose have an antidepressant effect.
The idea behind methoxetamine being "safer" than ketamine is mostly based on the assumption that if it is the metabolites that are responsible for ketamine's bladder toxicity, then the simplest way to reduce that toxicity would be to make a stronger, more long-lasting drug. If it takes a much lower dose to achieve a similar "high", and said high can be sustained for a longer duration without redosing, then you're ingesting less material, and therefore forming fewer toxic metabolites.
That said, there are studies on rodents suggesting that if you push the dose high enough (which a lot of people probably did during the peak of the RC boom), it's every bit as toxic as good old ketamine. Heck, mg-for-mg, it may very well be *more* toxic than ket.
Not that it really matters, because MXE is pretty much gone. Not only is it banned EU-wide and scheduled under the UN convention on psychotropics, but it has been *explicitly* banned in China, which is where pretty much all of it was synthesized.
The idea behind methoxetamine being "safer" than ketamine is mostly based on the assumption that if it is the metabolites that are responsible for ketamine's bladder toxicity, then the simplest way to reduce that toxicity would be to make a stronger, more long-lasting drug. If it takes a much lower dose to achieve a similar "high", and said high can be sustained for a longer duration without redosing, then you're ingesting less material, and therefore forming fewer toxic metabolites.
That said, there are studies on rodents suggesting that if you push the dose high enough (which a lot of people probably did during the peak of the RC boom), it's every bit as toxic as good old ketamine. Heck, mg-for-mg, it may very well be *more* toxic than ket.
Not that it really matters, because MXE is pretty much gone. Not only is it banned EU-wide and scheduled under the UN convention on psychotropics, but it has been *explicitly* banned in China, which is where pretty much all of it was synthesized.
im pretty sure pharmaceutical companies rip off everyone everywhere not just US.
its called "business"!? ever heard of business trying to benefit others but themselves?
well, maybe in communism, business is controlled by governments but thats not much better since government only looks after its own interests screwing people over as well