My ultimate favorite, we do it with my friends when we go to fishing:
We smoke a fat blunt. We drink whiskey and beers. Smoke another one. Repeat that couple of times, and when we feel like we're gonna pass out we snort a line of speed. A very thin line, nothing serious. And bumm! :D It takes away the tiredness, leaves the buzz of the bud and the alcohol, and gives me the energy to party.
(No wonder we didn't catch any fish, ever lol :D )
Since it's a harm reduction site I must remind you to don't do this combination often or if you have some heart problems. Take breaks in activites, sit down, drink a bottle of Powerade. (It's a good time for some deep talk, and then the party can go on). Don't forget to wear warm clothes, because if you snort speed on alcohol you will feel like it's July in December. :D