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Failure as a prodrug (Lisdexamfetamine)

T

TooMuch2C-E

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Jan 8, 2011
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For those who aren't familiar, lisdexamfetamine is analogous to dextrorotary amphetamine, wherein the amino acid lysine is coupled with the molecule to delay the onset of effects as well prolong it's duration. According to Wikipedia, in order for it to take effect, it needs to be converted to dextroamphetamine via the gastrointestinal track. I've used this substance numerous times, and more often than not, I took the insufflation method of administration. Contrary to what wikipedia tells me, I've found it to be quite active in that route. In one instance, I've used it to keep me going from a psilocybin trip one night, (Taking a 40mg [40mg = 30mg dextroamphetamine] dose every 8 hours) until the end of an MDMA high the next. It proved to make my tryptamine experience incredibly euphoric, and I found that it potentiated the MDMA....though any of you could figure that out based on data regarding dexedrine. All in all, I've found it to be a longer lasting alternative, and is therefore of slightly greater value than plain dexedrine. My question is, why is it active when insufflated if it's supposed to rely on the gastrointestinal track to be metabolized into dextroamphetamine? I know it's not the drips, as the amount ingested that way would barely be enough to provide threshold effects.
 
It's going to be active after its in the gastrointestinal track, that's the point behind it being formulated that way.

The pharm company was actually trying to get it to be C-III since its apparently "less abusable" if you can't snort it.

I'd be interested to see if anybody else had the same experience as TooMuch2C-E....

I would rather just take regular dexedrine orally.
 
The conversion doesn't have to be done in the GIT but can also take place in the liver by unspecific amidases. Because this needs some time, the onset will be delayed resp. the duration prolonged. TooMuch2C-E reported exactly this behaviour. Hence, I wouldn't say that the prodrug-concept failed (lisdexamfetamine is mainly used as time-released form of amphetamine!).

TooMuch2C-E said:
Taking a 40mg [40mg = 30mg dextroamphetamine] dose every 8 hours
Click to expand...
When speaking about amphetamine, users usually mean the hydrochloride salt, which is the by far most prevalent one (Mr=171.7). Lisdexamphetamine is sold as dimesylate (Mr=455.6).
40 mg Lisdexamfetamine (dimesylate) = 88 µmol
30 mg Amphetamine-HCl = 174 µmol
Ergo: The calculation is not correct.
 
Lol, I duno why anyone would attempt snorting, after its reported design.

After a while of empty stomach dosing, I could definitly feel it within 20 minutes, which I guess is not that different than IR
 
After a while of empty stomach dosing, I could definitly feel it within 20 minutes, which I guess is not that different than IR
Click to expand...

Varies greatly from person to person, as opposed to regular dexamphetamine sulfate, which is always more preferred. At least among the amphetamine users I know.
 
I prefer detroamphetamine 10 mg tablets, however I am prescribed to Vyvanse 70mg daily. I am unsure as to excatly how much detroamphetamine is converted from 70mg of lisdexamfetamine.
It takes about one hour for the effects to start when taking Vyvanse and I am told by my doctor that IV use is simply not effective with this drug, the person will will an amphetmaine "burn" like sensation upon injection, but will not recieve any sort of "rush" and it will mostly be wasted when done this way. I have never snorted or injected Vyvanse so I do not know if this is true or partly true or what effects snorting or injecting may have.
 
I swear I read a study online about people snorting lisdex and found it had a ~40% BA.
 
I haven't tried snorting or plugging my Vyvanse either since the lysine molecule has me to believe the prodrug statement. 100mg once a day has me euphoric for the entire day. Vyvanse seems to be well tolerated by the body compared to regular amphetamines. Vyvanse seems to have a magic that feels the same day after day where as adderall or dexadrine feels half as effective the next day. If you want a real rush take 300mg of vyvanse it's comparable to meth. I feel euphoric for over 8 hours steady and feel stimulation for up to 24 hours.
 
Well, wikipedia lied to me then.
And uh, it's not my prescription, I wish I could get 300mg goin at once.
 
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From personal experience i can confirm that it is active snorted. This was before I was aware of the fact that it needed to be metabilized to be active, but my ignorance did not prevent a buzz. Not recomending this ROA by any means.
 
I'm used to lots of dextroamphetamine 5mg & 10mg (over 50 times) as well as a bit of experience with Adderall (under 10 times), also tried meth 2-3 times, smoking it, eating it (orally) and snorting it. Recently i've gotten some Vyvanse 20mg capsules and although im not a fan of stims i used it for when i was very high on opioids.
Snorting 20mg of this did absolutely nothing but taking 20mg orally def had an effect on me peaking after 2hr and resembling about 10mg dextroamphetamine however its very long duration doesn't make me a fan.
 
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