FAAH inhibitors

[planckunit]

Fatty acid amide hydrolase inhibitors, anyone ever tried them? They are supposed to have a cannabis-like effect, but I have never heard of anyone actually trying one of them out. I have access to a possible source, but it would take a lot of effort, and I'm not sure it would be worth it. The one I have "access" to is URB-524, by the way.

 

[LuxEtVeritas]

they do NOT produce the effects one would desire even though on paper one might suspect such

 

[Riemann Zeta]

Alas, their effect on cannabinergic (that's a fun word) transmission is not strong enough to engender cannabis-like effects. Kind of like how an enkephalinase inhibitor is not strong enough to engender opioidergic effects. Might it potentiate cannabis, however?

 

[LuxEtVeritas]

i would think only if the direct agonist has both the true direct agonist effect AND is a FAAH substrate

i do not believe THC is a substrate so unlikely to make a notable rec difference

 

[Riemann Zeta]

Ah, but what about endogenous cannabinoids? There have to be a few of those CB1 receptors floating about unagonized, even in the presence of THC. Amandamide and 2-AG are fairly potent agonists at the CB1 receptor (Kd in the nM range), rivaling THC. Whether or not they produce veridical or even 'close-enough' phenomenological states is, insofar as I know, never really been tested in humans, as most lipid-based amandamide-based cannabinoids would be crushed in the gut and wouldn't survive the flame of a bowl or a blunt.

 

[nuke]

How are these things on safety? They sound like they could make nice antidepressants. For the chemists, is URB597 a difficult or costly synth? It doesn't look that complicated..

 

[planckunit]

How are these things on safety? They sound like they could make nice antidepressants. For the chemists, is URB597 a difficult or costly synth? It doesn't look that complicated..

If you can get the right precursors, which AFAIK are not controlled, it should be a piece of cake.