redeemer
Bluelighter
- Joined
- Sep 14, 2003
- Messages
- 2,135
I tried posting this in Drug Basics but I didn't get much repsonse, probably because it isn't so basic. Well, I have some pills containing:
codeine phosphate hemihydrate: 9,6 mg
acetylsalicylic acid (aspirin): 500 mg
magnesium hydroxide: equivalent to 150 mg magnesium oxide
The reason a cold-water extraction won't work is because the magnesium from the magnesium hydroxide will react with the aspirin creating a very water soluble magnesium salt of aspirin. The procedure I use for getting rid of the aspirin is as follows:
Dissolve pills in approx. 4 mL water per pill. Cool to 5°C, filter off insolubles (this will be the binders etc. in the pills)
Add small portions of 30% HCl to the now filtrated pill solution. A white precipitate is seen falling out of the solution, cease addition of HCl when no more precipitate forms.
Filter off insoubles again (this should be the aspirin). I then neutralize the solution with Na2CO3 and the result is an almost clear solution with a slightly yellowish tint.
As far as I can see this procedure should work in theory, should it not?
I did this last night with 35 pills containing 350 mg codeine in total. It's hard to say how much of the solution was lost in the filters etc. but I'd say a yield of at least 80% was achieved, that's 280 mg codeine.
I ingested this last night and not much happpened really. Previously I have tried with 8 pills, then 16, 20, 30 and now 35 pills and I don't feel much of an effect. Maybe a tiny bit drowsy but this could just as well be placebo.
Is there a critial flaw in my preparation of the codeine or should I just try with more pills?
Thanks in advance,
-Redeemer
codeine phosphate hemihydrate: 9,6 mg
acetylsalicylic acid (aspirin): 500 mg
magnesium hydroxide: equivalent to 150 mg magnesium oxide
The reason a cold-water extraction won't work is because the magnesium from the magnesium hydroxide will react with the aspirin creating a very water soluble magnesium salt of aspirin. The procedure I use for getting rid of the aspirin is as follows:
Dissolve pills in approx. 4 mL water per pill. Cool to 5°C, filter off insolubles (this will be the binders etc. in the pills)
Add small portions of 30% HCl to the now filtrated pill solution. A white precipitate is seen falling out of the solution, cease addition of HCl when no more precipitate forms.
Filter off insoubles again (this should be the aspirin). I then neutralize the solution with Na2CO3 and the result is an almost clear solution with a slightly yellowish tint.
As far as I can see this procedure should work in theory, should it not?
I did this last night with 35 pills containing 350 mg codeine in total. It's hard to say how much of the solution was lost in the filters etc. but I'd say a yield of at least 80% was achieved, that's 280 mg codeine.
I ingested this last night and not much happpened really. Previously I have tried with 8 pills, then 16, 20, 30 and now 35 pills and I don't feel much of an effect. Maybe a tiny bit drowsy but this could just as well be placebo.
Is there a critial flaw in my preparation of the codeine or should I just try with more pills?
Thanks in advance,
-Redeemer
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