Stimulants Ever combine methamphetamine with mirtazapine

[JohnBoy2000]

And what's the best way to dose meth?

Insufflation, oral, injection?

I tried oral just now and it gives a nice hit.

Are other ROI's better?

But as to the OP, anyone ever use it with an autoreceptor blocker like mirtazapine?

Should increase the high, right?

 

[JohnBoy2000]

Erowid Methamphetamine Vault : Dosage

Information on methamphetamine (meth) dosage.

www.erowid.org

I'm just reading on erowid that iv injection makes the dose last longer, and produces better effects.

Can anyone attest to that?

 

[negrogesic]

Mirtazapine reduces the high of methamphetamine mostly through its serotonin antagonism and to a lesser extent through its blockade of the norepinephrine transporter. Methamphetamine still works on it but I found that one needs more.

 

[✿Dai₷y✿]

And what's the best way to dose meth?

Insufflation, oral, injection?

I tried oral just now and it gives a nice hit.

Are other ROI's better?

But as to the OP, anyone ever use it with an autoreceptor blocker like mirtazapine?

Should increase the high, right?

Mirtazapine didn't enhance anything for me, mind you it has been many years since I was prescribed mirtazipine and was smoking/iv up to a gram a day.

I used mirtazipine around 2am after shift work and used to get high a few hours before work so I recall having sleep despite meth.

It isn't a good recommendation, I wouldn't wish daily meth habit on anyone.

Iv meth is better than any other ROA, if it wasn't no one would do it.

 

[JohnBoy2000]

Iv meth is better than any other ROA, if it wasn't no one would do it.

Has anyone experience comparing this ROA with say, oral?

If it could cut down on the dose being administered and prolong its half life, it's certainly worth considering.

 

[SKL]

Has anyone experience comparing this ROA with say, oral?

If it could cut down on the dose being administered and prolong its half life, it's certainly worth considering.

MA has an oral bioavailability (BA) of 70%, i.e. 30% of the dose is lost relative to taking it IV, which by definition has 100% BA. Smoking and snorting have roughly similar BA but quicker onset than oral. Oral dosing will last slightly longer than other routes.

I wouldn't recommend that anyone inject drugs. It brings a whole host of problems of its own. If you're looking at it from strictly a dosage perspective just don't do it, it's not worth the trouble. People who inject generally are chasing the "rush."

As for Remeron, I don't know where anyone got the idea that it would potentiate meth. If anything it would blunt the effects, especially the serotonergic effects at higher doses—which most people find desirable.

 

[JohnBoy2000]

A very cautionary vibe in relation to meth.

But isn't this medically prescribed for ADHD and other conditions?

I understand many problems come with tolerance and using ridiculous doses but, medical prescription claims it's typically admin'd at about 25 mg per day.

Keeping within that range, could it preclude many of the drawbacks?

 

[SKL]

A very cautionary vibe in relation to meth.

But isn't this medically prescribed for ADHD and other conditions?

I understand many problems come with tolerance and using ridiculous doses but, medical prescription claims it's typically admin'd at about 25 mg per day.

Keeping within that range, could it preclude many of the drawbacks?

While Desoxyn (pharmaceutical MA) is not commonly prescribed, it is a good ADD med among a few other things.

Lower dose (say, <50mg) oral MA is not just a different ballpark but a different sport than high dose MA typically done by recreational users. In those doses it is relatively safe, when used in moderation and with due attention to taking care of yourself i.e. eating and sleeping. Some people find that lower dose stimulants benefit them in various ways. more commonly people talk about Dexedrine in this context though. It is debatable how dangerous this is but it is definitely nowhere near as a dangerous as typical recreational meth-head use.

 

[JohnBoy2000]

Serious increase in intraocular pressure - horrible.

I can hear myself blink.

Blurred vision - 20 mg was WAY to much, despite being a conservative dose.

I figured mirtazapine would potentiate the NA effect of meth via blocking the autoceptors - unless meth doesn't work as a convention reuptake inhibitor (does it?).

 

[Joey]

Ive taken is in small amounts mitrazapine as in one pill. Helps as a sleeper.

 

[SKL]

Ive taken is in small amounts mitrazapine as in one pill. Helps as a sleeper.

Yep. Interestingly enough due to it's pharmacological peculiarities a smaller dose (15mg) is actually better than a larger one (30mg) for sleep. I take it daily for sleep, 15mg at night. It's not that high a dose for the antidepressant effects of the drug, but every little bit helps Remeron is pretty benign, and classed as "not habit-forming," but there will be withdrawals of some type if it is stopped abruptly. Mild, not as bad as SSRI brain zaps or anything, perhaps in some not even noticeable, but some w/d from the antidepressant effect.

 

[JohnBoy2000]

This is extremely dicked up.

i haven't eaten or slept in 24 hours.

I feel like my eyes are going to melt and even standing up makes me feel ill.

Just gotta sit tight and wait for this misery to pass.

Conclusion - crystal meth is not to be fucked with.

5 mg - start low, edge up on a weekly basis as required (/as per clinical recommendation).

Hitting 20 mg for my first dose was an extremely ambitious leap of faith.

 

[JohnBoy2000]

I'm 28 hours removed from dosing, and my jaws are still torquing involuntarily.

I must say I'm frankly shocked at how powerful this drug is.

 

[Jabberwocky]

Conclusion - crystal meth is not to be fucked with.

Truer words have never been spoken. If you don’t watch yourself the following pattern will emerge:

1. You will try to maintain low doses believing you are after cognitive enhancement
2. Tolerance builds quickly and euphoria is the first meth benefit that you lose with ongoing use but you keep wakefulness and pro-sexual effects
3. You start taking larger doses as you fruitlessly chase that initial euphoric feeling
4. Tolerance builds and your increasing doses combined with sleeplessness start to fuck with your cognitive skills and reduce your IQ
5. You don’t get so much of a buzz out of meth, you just feel twacked out and kind of stupid, it no longer gives you lots of energy
6. You are now addicted

 

[JohnBoy2000]

Truer words have never been spoken. If you don’t watch yourself the following pattern will emerge:

1. You will try to maintain low doses believing you are after cognitive enhancement
2. Tolerance builds quickly and euphoria is the first meth benefit that you lose with ongoing use but you keep wakefulness and pro-sexual effects
3. You start taking larger doses as you fruitlessly chase that initial euphoric feeling
4. Tolerance builds and your increasing doses combined with sleeplessness start to fuck with your cognitive skills and reduce your IQ
5. You don’t get so much of a buzz out of meth, you just feel twacked out and kind of stupid, it no longer gives you lots of energy
6. You are now addicted

This basically predicted my thoughts on it currently.

I had considered a low interval dosing program (not more than once a week) of 5 mg, to attain as it were, cognitive insights that may not be otherwise apparent.

Or, I had been considering that, but I'm now almost 48 hours removed from a 20 mg dose and although it's largely dissipated, I still have some "residual" jaw torquing.

Just weighing the pros and cons; I'll certainly wait at least a week or two before deciding to re-dose or simply be satisfied with a one time experience.

- My aim here is not "getting high", or even euphoria, but very specific cognitive application, changing regular day to day outlook to attain that change in perspective as a means to attain said unique cognitive insights - kind of like a "culture shock", in manner of speaking.

It's entirely possible however that one dose has provided that already, and in a sense there's no further benefit to me hanging out in this unique land of cognitive acuity - I've soaked up all the cultural perspective from this environment I can benefit from, so it's one and done.

....

So yeah, perhaps I'll get more clarity on whether that is or is not the case over the coming time period (at least 2 weeks I would imagine).

 

[Jabberwocky]

Keep us informed of your progress. It’s a tricky experiment you are trying and many have fallen by the wayside giving it a go.

 

[✿Dai₷y✿]

Has anyone experience comparing this ROA with say, oral?

If it could cut down on the dose being administered and prolong its half life, it's certainly worth considering.

Done them all. I suppose it would cut down what seems to be the time affected due to being absorbed straight away but through mucus membranes or eating it doesnt take that much longer to be worth it.

Smoking it is more a prolonged use thing as that is Moorish and takes time.


Mirtazipine helps the crash imo. It made me feel a bit blah the next day hence I kept using.


I dont understand the experiment, sounds a bit weird and wouldn't comment further on it .

I wasn't co ducting any experiment, just trying to deal with a habit without taking time off. It sort of helped, wouldnt really recommend it though.

 

[JohnBoy2000]

Keep us informed of your progress. It’s a tricky experiment you are trying and many have fallen by the wayside giving it a go.

Well, almost bizarrely thus far, as much as I can currently deduce, the "groundbreaking cognitive insights" acquired whilst using meth - now 48 hours removed from the dose, were actually a function of the drugs nature itself;

Not some revolutionary personal or self insight and associated cognitive advancement.

i.e. using meth, for me at least, it just skews genuine functional cognition, almost turns it inside out.
I couldn't differentiate that whilst in its effect window, but now the other side of it (no longer under its influence), it seems much clearer.

I used the example of being on meth like experiencing a "culture shock", but now I see it's the equivalent of experiencing the culture of a hore house and in contrast to how normal women typically respond to you, having the "cognitive revelation" that you must be far more attractive that you had previously thought.

What I'm saying is, I may have overestimated the cognitive benefit I could acquire from high potency drugs that have applicability in a recreational capacity.

**
Which I'm a little glad to have realized cause, I was in the process of lining up every other recreational drug for experimentation, i.e. to maximize all these potentially untapped cognitive benefits.

 

[✿Dai₷y✿]

A very cautionary vibe in relation to meth.

But isn't this medically prescribed for ADHD and other conditions?

I understand many problems come with tolerance and using ridiculous doses but, medical prescription claims it's typically admin'd at about 25 mg per day.

Keeping within that range, could it preclude many of the drawbacks?

Methsmphetamibe is not amphetamine sulphate or d-meth.

Methamphetamine is a whole different animal and monyou dont and won't really appreciate the tolerance build up and addiction this drug causes unless you develop it.

2 points for a first dose?

Mats, I dont know you and haven't read around to see if you are kidding or not.

Dont do any weird experiments or trials with this drug. Its not a research chemical, totally researched out and known.

If you're going to do it, go for it but its on you to utfse and read about it at least. Dont use every day, just dont.