Etizolam Powder Dosage Help

[dooljigger15]

Hello,

I have a quantity of pure etizolam powder, but right now I don't have PG or pure ethanol to dissolve it in. here are some of the options I was thinking. Which is best? any other suggestions?

1)stick the tip of a tooth pick in the powder and put it in my mouth. Anyone wanna take a guess at how many milligrams that might equate to?

2)dissolve the etizolam into Rogaine which contains alcohol, PG, and water (in that order though the exact % cannot be determined through the label) and rub on skin?

3)dissolve the etizolam into 190 proof Everclear and apply to skin.

3)dissolve in 90% isopropyl (rubbing) alcohol and apply to skin.

Also, is it allowed for me to ask for links to good vendors for pharmaceutical grade PG and DMSO (both legal)? If not could a mod just delete the offending substances from the preceding sentence, or the whole sentence if necesary?

 

[Mugz]

Welcome to bluelight If you have powdered etizolam I would wait until I actually have a decent solvent to dissolve in, maybe you can find out online what the %s of the ingredients to Rogaine are to make a decision as to whether or not to use it. If you start using any other way to dose with powdered etiz you can easily end up taking too much, I have dabbed at powder etiz before but it wasn't a wise choice.

Also why are you considering applying a solution to your skin to dose as opposed to drinking it, or pouring into some soda and drinking it?

Thirdly, it isn't allowed on bluelight to give out vendor information even for legal things like paraphenalia and solvents, sorry.

 

[Swimmingdancer]

Hi dooljigger15,

I'm not sure if rubbing it on your skin would provide very good absorption. The best way to take etizolam is orally and the best ways to measure your etizolam dosage are by dissolving it in PG, glycerine, or ethanol, or measuring it with a mcg scale. Perhaps glycerine would be easier for you to find?

We don't allow source discussion for anything that isn't strictly a harm reduction material, and even then it is limited to sites that only sell HR materials. It doesn't matter whether the item is legal or not. We don't have time to check every post that contains a link to a source to see whether the poster might be advertising something, or whether the source also sells drugs, etc. We want to remain impartial and not been seen as promoting anything or helping people get high. I'm honestly not sure if PG would be considered an HR material in this case, so I'm going to err on the site of caution and say it's not allowed, besides, PG, glycerine and ethanol should be relatively easy to find on your own.

Out of the options you listed I would use the Everclear. But I don't see the need to rub it on your skin. Maybe just start with a slightly smaller dose to be on the safe side, just in case the drug is not completely evenly distributed in the solution. At least Everclear is made for human consumption and it has a very high ethanol content.

 

[dooljigger15]

hey guys thanks for the responses.

I'll look into Glycerine, an excellent suggestion! how much eti would dissolve into 1ml glycerine do you think?

I'm not sure rubbing it on the skin would provide very good absorption either, hence the need for DMSO which (so i've read) greatly increases absorption through the skin.

The reason I want to rub it on the skin is i'm trying to turn a substance that is immediate release into a gradual release. But i should admit that i don't really know if that would work or not... my understanding is that with most drug patches the patch itself plays an integral role in the slow distribution of the drug. It could be that rubbing it on my skin wouldn't effectively draw out the dose as i intend. You see i'm actually using eti to reduce anxiety not to get high (in this case hehe), so i actually want it to last awhile, and eti already has one of the shortest half lives of all the benzos. I have had experience with the brand name eti in 1mg tablet form and i don't know how long those take to break down in the body, but the pills are hard as hell (they are the hardest pills to crush i have ever crushed by far) so although not marketed as controlled release I suspect it takes awhile for the pill to break down. If i take this powder by any route other than skin it's going to hit harder and faster than what i'm looking for. If anyone has any ideas for getting this powder to be time released please let me know.

 

[Swimmingdancer]

Oh that's an interesting idea. I know some benzos are available as a skin patch, although it is uncommon. I have no idea how well etizolam would work this way or whether the patch ingredients are an important component. It might be worth some experimentation, but be careful to start out with a small amount in case it does absorb well/rapidly. Another option would be to take very small doses orally throughout the day. If you want to put in the effort you can make your own time release pills using food-grade cellulose and gel-caps. I've also heard of people using edible wax but that is not as reliable/consistent.

I think you could probably dissolve 1mg per ml in glycerine or ethanol. I have heard of people doing that. I wouldn't bother with trying to fit more than 1mg in each ml, because then the dosing gets more difficult to measure. If you are going to put it on your skin the Everclear might work better than glycerine, as glycerine is not going to absorb or evaporate very quickly.

I hope you know though that benzodiazepines/thienodiazepines are not very effective for long-term continuous treatment of anxiety and that they create a serious physical dependence.

 

[dooljigger15]

ok thanks again for the reply, you are a wealth of knowledge!

are food-grade cellulose and gel caps fairly cheap and easy to assemble at home?

I wonder if there is anything i need to worry about with regard to preservation? it will take me 3 months to use this quantity of solution.

does it need to be shaken regularly or will it stay fully dissolved and evenly distributed in the solution throughout the duration? i suspect i dont need to shake it and the solution will remain homogenous but I was a humanities major so someone with a chemistry background please correct me if i'm mistaken.

I am aware of the tolerance and withdraw dangers, but thank you for point it out.

 

[dooljigger15]

bump - i edited the above post to get to the point. if anyone wants to take a shot at one of the questions i would appreciate it.

 

[Swimmingdancer]

Sorry I didn't see your last post

Yes, you can buy cellulose powder available as a bulking agent or fiber supplement and you can buy empty gel caps. Then you would just mix your dose in with enough cellulose to fit in the capsule. EDIT: However, I can see a few potential problems with using this method for etizolam. You might not get even distribution of the drug if you just made a big batch of cellulose + etizolam powder and then divided it and put it in capsules (which would be problematic for etizolam since it is active at such small doses). And if you put the etizolam in glycerine first and then mix it with the cellulose, then it might soak through the capsules (and I definitely wouldn't recommend making a bunch of capsules and then storing them if you were going to try it this way). If you are willing to spend a bit of effort experimenting, the cellulose and capsules should be pretty cheap. If you are going to try putting the etiz in glycerine and celloluse - which I'm not sure would actually work - I would make each capsule separately to ensure you are getting the correct amount of etiz in each capsule. So it might be kind of painstaking. I don't know of anyone who has made time-release capsules this way with a liquid, so I'm not sure whether it would work properly.

The other thing I should mention is that I have not actually tried the cellulose capsule thing myself, so I'm not sure whether it does in fact work properly and provides a true sustained-release as opposed to just a delayed release. It's just something I've heard of people doing. This is what I found from a drug manufacturing company:

To achieve controlled release through the use of a water-soluble polymer such as cellulose ethers, the material quickly hydrates on the outer tablet skin to form a gelatinous layer. Once the original protective gel layer is formed, it controls the penetration of additional liquid into the tablet. As the outer gel layer fully hydrates and dissolves, a new inner layer replaces it and retards the influx of water and control drug diffusion.

So it kinda sounds to me like making the capsule contain glycerine might defeat the point.

As for the glycerine solution, I would probably stir before each use to be on the safe side.

 

[dooljigger15]

oh no worries, that wasn't directed at you. just wanting to dot my "i"s and cross my "t"s so to speak.

do you have an understanding of chemistry? your better safe than sorry philosophy is a good advice on a forum devoted to harm reduction, but i was curious if someone with a natural sciences background could answer my question about the homogeneity of the solution over time.

time is something that I do have, so I'm going to look into making my own capsules. I'll report back sometime later with the outcome of my little endeavor. in light of your edits, i'm going to look into it more to see if it's feasible.. If you're anywhere as close to the mark about the gel-caps as you were about the glycerin then the suggestion is dynamite. ideally if i could just procure a small amount of

the more i think about it i don't think applying it to the skin will work; i think that may delay the release but i still think that what does get through will all hit me all at once. I think that with other time release formulations in patch form it's the patch itself that is controlling the dose over time.

thx*1000

 

[Swimmingdancer]

It is my understanding that if it is forming a proper solution, then unless you use more etizolam than can be dissolved in the quantity of glycerine, it should form a homogenous evenly-dissolved solution. So the drug concentration should stay the same throughout the liquid and you should not have to stir it. The only reason I said maybe I might stir it to be on the safe side is because I am paranoid (lol) and I don't actually know exactly the solubility of etizolam in glycerine or the purity of your etizolam. But I am actually 99% certain it should not require any stirring once it has been fully dissolved. If it is a proper solution it will be clear and if you shine a beam of light through it you will not be able to see the beam in the liquid (like when you shine a light through air). Unless your etizolam powder has a lot of impurities or something, which could make it cloudy. I have heard people say they have dissolved up to 8mg/ml of etizolam in PG, so I really think 1mg/ml in the glycerine should be plenty soluble.

The only preservation issues for the etiz/glycerine solution that I can think of involve contaminants. If you keep it sterile, well-sealed, and stored in a cool dark place it should have a shelf-life of 1 to 2 years. Glycerine is a preservative, is bacteriostatic and might even have some bactericidal properties. [source]

As for the gel caps thing, I think if your idea was to dissolve the etizolam in glycerine and then make it into gel caps with the cellulose then more research is needed before bothering with this. I'll see if I can find out any info on whether or not having a liquid in the mix would make it not work properly.

 

[dooljigger15]

Thanks dancer. I'm gonna hold off on making the time release capsules for now. 1ml of liquid to 1 mg of eti dissolved easily. I'm not gonna add anything to the glycerine solution to help preserve it as that was also my understanding that it was a natural preservative.

 

[AlphaOdure]

BUM PING ,,,id like to consider lower proof ethanol for dissolving? Around ~50%-60% ethyl alcohol.... i would obviously intensely shake the formula before dosing w/ an oral syringe, too.

Anyone use this method? If so, is the dissolving solvent to etizo ratio linear?? relative to near pure ethanol? I do not have the cash, nor will i EVER, to purchase a mcg scale or a more appropriate solvent (and "everclear" or anyhing above i believe around ~80 or 90 percent ethanol is illegal in my state)

THESE ARE MY ONLY OPTIONS! so in the name of our mission statement/purpose here at BL.... i'd prefer harm reduction responses! Not: "oh well, don't do it then".. b/c i'll end up doing it anyway, just w/ less help/info from you all!!!

Thanks in advance
Regards
~AA

 

[WorldWarMe]

Licking the tip of a toothpick and dipping it into the bag is quite common from what I've read, you'd get anywhere from 1-5mg, but as I'm sure you know there's no real way of knowing by using a toothpick.

I highly advise calling your local pharmacies and asking if they'll sell you some of their Propylene Glycol stock. If you have 250mg Etizolam, buy 125mL Propylene Glycol and mix the two ruthlessly together. You'd have a 2mg/mL solution. It's MUCH safer than using a toothpick.

Also, sourcing isn't allowed on BL.

 

[Pretty_Diamonds]

lick a little bit of your finger (center of finger print), dip, repeat 3 times. Well, maybe try it once/twice, wait an hour, see how you feel.

But if you do the liquid thing.. can't you just use water? 0.0?

 

[WorldWarMe]

lick a little bit of your finger (center of finger print), dip, repeat 3 times. Well, maybe try it once/twice, wait an hour, see how you feel.

But if you do the liquid thing.. can't you just use water? 0.0?

Benzos are not freely soluble in water. This would NOT work.

 

[Aspiring Chemist]

What do people typically us PG solution for? Should I check w/ some pharmacies I usually do not goto?

 

[FluoTox]

What do people typically us PG solution for? Should I check w/ some pharmacies I usually do not goto?

E-Liquid base for E-Cig (without nicotine of course).

 

[dopemegently]

I had the exact same problem as you and found a simple solution. You can cut etizolam with sodium bicarb or other inert powders; if you dye the bicarb it's easy to see if your drug is well cut (this isn't necessary, but it makes things easier). I used a ratio of 2mg etizolam to 50 mg of sodium bicarb, and it worked perfectly. You have to be extremely methodical when making your mix though; I used a mirror and razor blade and spent ages cutting and crushing the powder-a sharp razor is excellent for picking up every last mg of drug. This is my preferred method of dosing raw etizolam, I personally wouldn't use a liquid. (I wouldn't want to risk the drug degrading in PG). If you were going to press your own tablets or make your own caps, this would be the logical way to go about it imo. I make capsules, and they're superior in effect to any pre-made etizolam tablets I've brought, and I've tried most of the big "brands".

Whatever you do, don't risk taking the raw drug! It's very fucking risky, and really not a good idea. All it takes is one overdose, and this whole rc benzo game could come crashing down.

 

[tyrael]

Oh that's an interesting idea. I know some benzos are available as a skin patch, although it is uncommon.....

Hmm, idk about ID patches for benzos - any benzo (or class) in particular?

....I hope you know though that benzodiazepines/thienodiazepines are not very effective for long-term continuous treatment of anxiety and that they create a serious physical dependence.

This ^^^

It is my understanding that if it is forming a proper solution, then unless you use more etizolam than can be dissolved in the quantity of glycerine, it should form a homogenous evenly-dissolved solution. So the drug concentration should stay the same throughout the liquid and you should not have to stir it......

I would personally just give it a quick stir! I'm not sure if you can guarantee a homogeneous solution (the difference between a liquid and gas; the gas will fill all spaces). If you've created a suspension, what would be the affinity of PE/etzi (and hence the binding of the two chemicals and it's solubility)?
Some benzos do come as a solution (Alpraz, Loraze, etc) for hospital use so it can (should be able to) be done.

Etizolam is effective at (just) mg dosages right? Couldn't one (with mg scales) just weigh 1-2mg? This could get dangerous if one is already, ermm under the influence, though hey? A (PE) suspension would be safer re HM.

 

[tyrael]

Solubility Definitions from Sigma-Aldrich (apparently)

Description Approximate Volume (ml) of Solvent
Needed to Dissolve 1g of Solute

Very Soluble Less than 1
Freely Soluble 1 to 10
Soluble 10 to 30
Sparingly Soluble 30 to 100
Slightly Soluble 100 to 1000
Very Slightly Soluble 1000 to 10,000
Practically Insoluble Greater than 10,000

A Sigma-Aldrich search comes up with this.

Analysis of Etizolam (Under the Condition of the draft for the Japanese Pharmacopoeia, Etizolam Tablets).

I'm searching peer-reviewed journals now (ya got me interested! >_<)..... (if anyone wants the full paper let me know and I'll send it over)

The effects of prolonged exposure to and subsequent withdrawal of the thienotriazolobenzodiazepine etizolam on γ-aminobutyric acid (GABA) type A receptor gene expression and function were compared with those of the benzodiazepine lorazepam.....These data suggest that etizolam is endowed with a reduced liability to induce tolerance and dependence compared with classical benzodiazepines.

Low tolerance and dependence liabilities of etizolam: Molecular, functional, and pharmacological correlates. Imo this is a general, overall good article on the pharmacology (compared to Lorazepam) of Etizolam. It does get quite technical however somewhat!