Ethylphenidate dose

[RobotRipping]

I've searched but found no concrete dose, anywhere from 50mg to 200mg.

I have 90mg to test, should I do two runs or just one? I don't want to be unnecessarily disappointed.

Thanks for any help

 

[sekio]

Methylphenidate is nice and active in the 10-30mg range, try there.

 

[mrflippy]

If you mean methylphenidate, 20Mg

 

[RobotRipping]

no ethyl, it's weaker cousin from what i read; well tried 40mg (i'm on benzos so prob wont feel as much). I'll report back with results if any.
Ended up doing 90mg sublingual and so far 2 hours in it is supreme, no jitters, jaw clench, just dopamine euphoria.

 

[Hajime]

To reference with 40mg extended release methylphenidate capsules, one can safely do 2 of them. I would say that perhaps your best starting with less but I would probably recommend 40mg and then wait 30mins and take the other 40mg...

EDIT: Also, it depends on what enantiomers of ethylphenidate you are dealing with... wikipedia as a nice little chart on the different affinities for the dopamine and adrenline channels and a comparison of that to methylphenidate. The reference on this chart is:

Patrick, K.; Williard, R.; Vanwert, A.; Dowd, J.; Oatis, J.; Middaugh, L. (2005). "Synthesis and pharmacology of ethylphenidate enantiomers: the human transesterification metabolite of methylphenidate and ethanol". Journal of Medicinal Chemistry 48 (8): 2876–2881. doi:10.1021/jm0490989. PMID 15828826

but it does seem that ethylphenidate has much higher adrenaline affinity in either racemic or dextro form than racemic/dextro methylphenidate. Anyone want to varify that Im reading the chart right?

http://en.wikipedia.org/wiki/Ethylphenidate

 

[sekio]

Please don't confuse adrenaline/epinephrine with noradrenaline/norepinephrine.

From the little chart on Wikipedia, ethylphenidate is roughly 1/4 as potent as methylphenidate. I highly doubt anyone is providing pure D-trans-ethylphenidate. If it's any consolation ethylphenidate is much more selective for dopamine rather than norepinephrine.

The affinities can be pretty much disregarded in favour of the more informative uptake inhibiton efficacy (Uptake DA/NE) - the amount of drug needed to inhibit 50% of dopamine/norepinephrine transporter protiens. Lower numbers are better.

 

[Hajime]

Yeah sorry, didn't read the name of the tag properly ... Is TEP Ethylphendiate and TMP Methylphenidate? I have feeling that Im wrong as I remember reading something about ethylphenidate having better reuptake of DA/NA channels.

When you compare the ratio of NA/DA selection, Ethylphenidate is 11.22 and Methylphenidate is 12.63; just that ethylphenidate requires x4 the amount for the nearly the same effect.

On a side note, it would really suck if some1 took this as fact and it actually turned out to be the other way around... that dl-ethylphenidate is x4 stronger. I make a point of getting this clearly explained as it is important.

EDIT: just realisd that lower inhibition is better for binding than higher... basically, from what Iv read, u need 150-200mg for the same effect as 40-50mg of methylphenidate.

 

[sekio]

Ethylphenidate is more selective for DA uptake over NE uptake (look at reuptake values not affinity), and yes TEP is ethylpheidate and TMP is methylphen.

 

[Hajime]

Hey Sekio, I would be very appreciative if u could give a run down on why the reuptake inhibition of dopamine is more important the affinity for said channel? I'm genuinely having trouble understanding this properly and I fully understand that its not an easy question to answer.

 

[sekio]

Affinity is how tight a drug binds, "reuptake inhibition" in this case is how effective the drug is. The drug with higher affinity takes effect over ones with lower affinity, so this explains things like naloxone (very high affinity, low efficacy).