Ethylone + MDAI combo

[Bone14]

Anyone tryed this? Whats your thoughts about this, could it be good and be more methylone like?

 

[Solipsis]

It's worth noting that dopamine releasers + MDAI cause neurotoxicity and/or marked monoamine depletion for quite a while after. So it's best not to combine them but go for DARI's instead (dopamine reuptake inhibitors).

 

[IamMe90]

Can you cite a reference to that Solipsis? I've never really heard anything about that until just now, and have heard various suggestions from a lot of veteran users about using MDAI as a stimulant adjunct to give needed SERT to some lacking it, like M1. Can you explain to me why taking M1 + MDAI for instance, would be significantly more neurotoxic than MDMA which has a similar profile but more SERT? Just curious, thanks.

 

[PsychedelicPeptide]

I'd like to see a reference as well.

 

[Solipsis]

Can you explain to me why taking M1 + MDAI for instance, would be significantly more neurotoxic than MDMA which has a similar profile but more SERT?

I never said that I could make comparisons to MDMA, whether positive or negative. I mentioned neurotoxicity suggesting it as a possible associated consequence of monoamine level changes, though this is not nearly the same as what damage seems to be done when SERT and DAT are hijacked, SERT hijacking being a well-known MDMA-effect. So I do not want to emphasize the suggestion of neurotoxicity with certain MDAI combinations but rather emphasize the implications of monoamine depletion which you can try to fill in yourself, whether that be depression or attention problems or something else.

source

Combining the monoamine oxidase inhibitors, clorgyline (MAOA selective) or deprenyl (MAOB selective) with MDAI did not result in any long-term reductions of serotonergic markers. Similarly, combining the DA uptake inhibitor GBR-12909 with MDAI did not result in any long-term changes in monoamine levels at 1 week. In contrast, a single pretreatment or posttreatment with the nonvesicular DA releaser S-amphetamine and MDAI resulted in small but significant long-term changes in monoamine levels. More importantly, if a subacnte dosing regimen (every 12 hours for 4 days) was utilized, the combination of S-amphetamine with MDAI resulted in a marked long-term decrease in the levels of cortical, hippocampal and striatal 5-HT, 5-HIAA and the number of 5-HT uptake sites. The results are discussed in terms of the significance of DA and especially nonvesicular DA release in the long-term effects of MDMA-like drugs.

 

[PsychedelicPeptide]

Thanks for the link. I think I've read this one before heh.

Anyways IamMe90, I don't think MDAI + Methylone is anymore likely to cause problems than MDMA is. I would think it is probably easier to "take too much/overdose" on the MDAI + Methylone combo than MDMA though. A lot of factors go into this, dosing 2 substances versus just 1, MDAI being a very potent pure serotonin releaser, redosing when you're already high...

Of course the likely problem in using something like deprenyl instead of methylone or amphetamine is that you simply won't get as high. =/

 

[AlmostFamous]

Any updates? I'm interesting in this combo.