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Eth? your opinion guys?

Smyth maybe what u said is true, that the methylated version of amphetamine is more potent than other alkylations, but there is no evidence for that so far.
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Are you fucking joking me right? Like you didnt already know that.
 

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To be honest i didn't cuz i never found any articles about the potency of ethylamine compared to meth and amp, only articles about meth compared to amp. I already read that dimethylamphetamine was no dig deal at all, and thats why i got curious on ethylamphetamine. Since the methylated version of amp was so potent i was hoping to find another N-alkylated amphetamine which was even stronger.

That attachment of yours caught my attention, especially the 3rd one, if u could gimme a link to one of those books i would be really glad to have a look at it.

So, in short words ur saying that so far meth is the strongest amphetamine known?
(i know MDMA gives more euphoria, but after trying the 2,me and other friends saw that meth is in fact the strongest stimulant)
 
Yeah, meth is the strongest but not necessarily the best.
In terms of straight up stimulation, amp is like a 67 and meth is like a 161 and eth is roughly 103.

In defense of the 4-OAc-meth idea, dho, 4-EtO-meth is muy good.
(Four-EtO-meth is an entactogen, not a straight stimulant.)
 
f&b tasted Ethamphetamin (its in the stims of the future thread).It inclined me to try it as well.I mean its illegal in most countries and that says something.But I have never seen it appearing,a case that it won't be more potent than meth (choosing between 2 illegal compounds,the more potent will be chosen).
 
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Yeah, Eth is Schedule I. Meth is Schedule II. So far there is no OTC Sudafed Ethylephedrine to serve as the precursor, either.

But Ethcathinone just doesn't compare to Ethamphetamine.
It doesn't come close.
 
f&b suggested N-Allylamphetamine,that would be unscheduled.But is there a risk of going into MAO territory,no?
 
Helios. said:
Yeah, Eth is Schedule I. Meth is Schedule II. So far there is no OTC Sudafed Ethylephedrine to serve as the precursor, either.

But Ethcathinone just doesn't compare to Ethamphetamine.
It doesn't come close.
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Dont take me for some mad chemist, i gave up to that stuff looong time ago, but there is a not to hard clandestine way to make ethylamphetamine, so its actually possible that sumday we could find ethylamphetamine sold on the streets.

Meth can also be made from phenylalanine in 3 steps, the first 2 steps convert the COOH group into a CH3 group. Yup, the resulting substance is amphetamine.
Amphetamine is then gently vaporised inside a gas jar of chloromethane which attaches to the amine group giving methamphetamine and HCl.
If chloroethane is used instead of chloromethane, the resulting substance would be....*drums*...
Ethylampehtamine!!

Same thing applies to any chloroalkane... Interesting isnt it? Amphetamine can be converted into 'any' N-alkyl-amphetamine by this procedure. Of course the whole procedure its not as simple as i said, but the chemical mechanism is that simple.
 
N-ethyl-amphetamine is one of the mythical beasts that I have always wanted to sample and assay. From the little I have read (much of which is already described above), d-ethylamphetamine should be an equivalent, yet faster-acting and smoother version of good old fashion d-amphetamine. I am not sure about the toxicology of 'ethedrine,' however. As methamphetamine is significantly more neurotoxic than regular amphetamine (mg for mg), I wonder where the toxicity of ethylamphetamine would lie?

I would estimate that it is less neurotoxic than methamp. as it would be less likely to release 5-HT and might serve as a weaker DA releaser (the steric bulk might engender it with a more inhibitory, weaker substrate action at the DAT). Then again, in terms of SAR, it only takes addition of a meta-chloro moiety to turn d-ethylamphetamine into dexfenfluramine--a potent 5-HT releaser [oops, not true, memory error]. It would be interesting to know if ethedrine shares any of the cardio- or neurotoxicity of fenfluramine. I hope not, as it sounds like a winner.
 
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Yes, not all that impossible to synth.
Yes, ethylamphetamine < toxic than methamphetamine.
Eth only neuro/cardiotoxic a la fenfluramine if Ar-3-(-CF3)-yl-ated.
As for ne amp,
100:0, (d,l) is too jittery.
0:100, (d,l) is inactive.
50:50, (d,l) is ideal/often convenient.
70:30, (d,l) is optimum/somewhat inconvenient.
 
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Oh yeah, fenfluramine had a meta trifluoromethyl group, not a chloro moiety. Sorry, my bad memory must have confused fenfluramine and para-chloroamphetamine or meta-chloroamphetamine. Well, I would still love to sample some "ethedrine." That's kind of a cool name too...ethedrine (although under this old naming convention, amphetamine itself should be called amidrine, rather than benzedrine). I have been prescribed "ethedrone" (the active metabolite of the Rx drug diethylpropion) before, but it was not so great.

Helios, you think that enantiopure (d)-ethylamphetamine is worse psychically/physically than the racemate or the 'Adderall blend' scalemic (75% dextro / 25% levo) version? That is interesting, as dexamphetamine is so much smoother and less jittery for the PNS than (d,l)-amphetamine.
 
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are there any references to alpha-ethyl-pea? never heard of it and asked myself why while reading this thread.
 
Yeah its mentioned late in the stimulants of the future thread-its almost inactive.
 
5ht?

some ethylamphetamine has made its self available to me, i am quite picky about stims with serious risk of neurotoxicity...

so does eth have any affinity for 5ht receptors and resultant neurotoxicity ala methylamphetamine or is it only a DARI/releaser like amphetamine, someone said F&B might have had a table with the binding affinity of different substituted amphetamines, anyone have it on hand?

thanks
 
There's little doubt in my mind, based on published drug activity studies, that ethamphetamine is less toxic than methamphetamine by about 50 or 60%, and shorter acting as well, but since a larger dosage is required to achieve a similar effect, they may be about equally toxic in the long run. Both are at least partially metabolized to basic amphetamine.

Since ethamphetamine used to be a prescription drug in the United States, it probably isn't prohibitively toxic. (That is, I don't think you're dealing with another thalidomide.)

As usual, universal precautions apply. Namely, if you're going to test a new drug on yourself, start with a small dosage and work your way up. If not, I'm sure it shouldn't be hard to find a volunteer. According to wikipedia, eth was prescribed at 10 to 30 mg per day as an anorectic back in the day. A recreational dose is probably between one and two hundred milligrams.
 
<pyridinyl_30> said:
A recreational dose is probably between one and two hundred milligrams.
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i have heard multiple people site incredibly high numbers for a recreational dose of ethamp, call me crazy but i consider anything over 20mg of d-amphetamine very excessive (for recreational or therapeutic purposes and im a regular user!) if ethylamphetamine is more potent than amphetamine then im assuming anything over 30mg of the racemate will feel distinctly uncomfortable, but we will wait and see.
 
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