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Epsilon opioid receptor, anyone know more about it?

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Limpet_Chicken

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I came across some stuff when I was randomly browsing the net, concerning an epsilon receptor, with beta-endorphin as an endogenous agonist, and some etorphine derivatives as exogenous agonists.

Anyone know more about this one? I can't find shit when it comes to details.
 
Nope, although I haven't seen thta list before, thanks, thats going to keep me interested for a while...:D

Epsilon receptor has seemingly been cloned, blocked by naloxone, binding studies seem ot say there is another opioid receptor thats insensitive to mu,delta and kappa selective ligands, but I can't find out much more about it, although its still referred to on google as 'putative'
 
No, that particular page with a huge list of different receptors.

I knew of ORL, although not much about it, and the more well known mu, delta and kappa receptors already, seeing a putative new opioid receptor discovered just got my intellectual juices flowing really.
 
ORL receptors are also called nociceptin receptors, but I've never seen anything about an epsilon receptor (though it was probably the greek letter, which I wouldn't recognize without double checking ;))
 
recently i read an article concerning opioid receptors in which they stated that the epsilon-receptor is nothing more than a splice-variant of the µ-receptor gene.

i for myself, was disappointed about that fact, but my research regarding the €-receptor didn't go further though. :)
 
Can you perhaps explain splice variants a little more ? I have a pretty rough (read 'smooth as a sharks arse') understanding of the term, but only very rough, my area of experience, if thats what you can call it, is funky plants and fungi, and some autie-influenced chemistry freakery, but genetics isn't my strong point.

Gah, where is my hyperfocus when I need it:P
 
well, the opioid receptors are made up of amino acids (constituting a protein). inside the cell there are special proteins that act like scissors and therefore cut the amino-acid strands of translated recetor-proteins into shorter forms. this is called splicing.

btw, there are tons of splicing-variants of the µ-opioid-receptor, eg µ1, µ2 and the herein discussed epsilon. :)
 
Ah, thanks morphiquet, I didn't realise splice variants occured at the post-RNA transcriptional level.
 
I guess the real question out of all of this is: what is Limpet_Chicken doing with sharks asses?
 
It was an analogy.

Rough understanding.

Sharks have skin with lots of tiny raised abrasive scales, like sandpaper, hence, 'smooth as a sharks arse'

Ok, no, the real reason is I'm big into bestiality=D
 
It was a joke.

A hilarious one.

Some humans have a sense of humor, they enjoy comedians and clowns.

Okay, now you made a joke that put down beastiality. Fear the wrath! =D

((hope you're not upset :) I thought this was funny, but who knows, perhaps it's a New Yorker ;)))
 
Actually I'm a brit.

They say humour is the best medicine, but personally I prefer large quantities of CB1 agonists=D

Upset? meh, I don't really do emotion, its one handy thing about being an autie *carefully combs his hair over the pointy vulcan ears*

But goddamn I hate clowns, there is something fucking evil about clowns, they remind me too much of chucky the voodoo doll on MDMA:P
 
And I prefer large doses of opiates and 4-oh-dipt.

oh, the iprocin sounds great right now.
 
DMT is the one intriguing me at the moment, had a low dose twice, sub breakthrough, and it seems to be calling me back to somewhere I'd been before.

Just got to get around to extraction :)
 
I've wondered what receptor beta-endorphin binded to. I thought it might be one of the mu-receptors.
 
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