Psychotomimetic effects of high-dose enadoline
Only two subjects were exposed to the 160-μg/70 kg dose of enadoline and both experienced adverse effects; therefore, it was excluded from further testing.
The first subject reported no history of hallucinogen use, while the second subject reported limited experimentation with hallucinogens 19 years earlier. The two individual responses are described below. Data from these two experimental test sessions were not included in the data analysis. The final data analyses included only the eleven test conditions to which all six participants were exposed.
Participant no. 4
This volunteer received enadoline 160 μg/70 kg during his 11th test session; he had already been exposed to all
of the other doses of enadoline up to 80 μg/70 kg.
Twentyfive minutes after the injection, he reported somatic effects, including the sensation that his body was hot but unable to radiate heat.
Fifty-five minutes after the injection, he reported visual and auditory disturbances (an inability to read words on a computer screen, distortion of staff voices). At 68 minutes after drug administration, he reported visual and tactile hallucinations; these consisted of a “blue wing” that he was able to both see and touch, and he was observed to be moving his hand as if grasping an object. The participant continued to have somatic effects during this time (e.g., itching and chills).
Ninety minutes after drug administration, all abnormal effects had essentially resolved. The participant did not
recall these events after the test session. That evening he watched television with peers, ate without difficulty, and was pleasant and cooperative.
Participant no. 6 This volunteer received enadoline 160 μg during his ninth session; he had already been exposed to all of the other doses of enadoline up to 80 μg/70 kg. Within 10 min after receiving the injection, he reported unusual sensations, including the floor moving and his skin prickling. He became agitated, began swearing, mistrusting others, and accused staff of seeking to harm him. He removed the physiological monitoring leads and left the session area with staff accompanying. His gait was noted to be swaggering and unsteady. Within 2 h, the effect had resolved.
Afterward, the subject reported that he had seen and felt waves, for example, as a part of the floor.
He had felt that his body was blending with these waves. He reported he had felt others were conspiring against him in a desire to ruin his mind.
That evening he was cooperative and pleasant; recalled the earlier events and expressed embarrassment and remorse for his aggressive behavior and foul language.
It's a fascinating compound none the less.
