effect of dopamine/norephinephrine re-uptake inhibitors on dra/nra's

[allthegoodjwh's]

searched with no success, curious as to whether there would be a potentiation or an inhibition of the releasing agent's effects
logically it would seem that a dri would inhibit effects as it would prevent vmat2 reversal and the like
but some people have said that it actually increases the effects
i am looking for at least a semi clear answer about this, thank you

 

[pr0d1gy]

It would probably depend on affinity and the concentrations of the drugs in question. I don't think there is a specific answer for your question because the answer would likely vary depending on what releasers/reuptake inhibitors are being discussed.

Generally speaking I'd think most common DRIs and DA releasers would have cumulative effects at any sane dosage.

 

[allthegoodjwh's]

the ones in particular being dexmethylphenidate, and dextroamphetamine (i tend to find the dextrory half much cleaner and less punishing than the racemic alternative)
that is what i was thinking, but i was just curious as to if the dri would clog the transporter and render the amphetamine's releasing properties disabled and basically useless hence a complete waste. i mean theres also taar1 activity and other mechanisims at play but in my research it seems some answers were that yes, it would block the transporter from releasing additional dopamine. and others were that it would cause potentiation (which is what i would believe) but like i said i was just looking for a semi-clear answer to base further research on the subject off of

 

[Epsilon Alpha]

If you haven't saturated the transporters with the more potent agent (in terms of elevating the extracellular DA/NE levels) then by combining them you will get a additive effect.

So low doses are additive, high doses are inhibitory if that makes sense.

 

[allthegoodjwh's]

so epsilon, basicallly what your saying is low dose the dri and it will potentiate the amphetamine, i guess its just down to finding the correct dose, basically a "celling" as if you pass that amount it becomes counter productive

also i assume dosing it on the comedown would help as it would help keep more dopamine in the synapes and make it more like a fender bender instead of a head splitter

 

[polarbearsarecool]

its dependent on concentration, affinity etc
A good example being people attempting to combine modafinil with amphetamine, modafinil a dri, while amph is a dra dri etc but by taking both together there is a dampening in the amphetamine's effects because moda has a higher affinity... however low dose of moda 10-50mg and amphetamine can potentiate the studying/effects, I have constantly used this combo and even adding 10-50mg moda while coming down or @ t: 5-6 hrs after ingestion it can smooth out the ending or even accentuate it to cause studying.

low dose of antagonists etc along with agonists, releasers etc will usually potentiate the transmission @ the receptor as long as the concentration of the drug with the higher affinity is LOWER, as explained with moda but also with ULD Naltrexone/ opiate agonists