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ecstasy potentiators?

COMT Inhibitors,, MAO-B Inhibitors, and CYP3A4 Inhibitors are all available as a nutritional supplement


Quercetin acts as a Triple inhibitor, as it inhibits the above 3
Green Tea (EGCG) is a COMT Inhibitor as well as a decarboxylase Inhibitor.

Piracetam also potentiates nearly all stimulants.
Choline isnt required for this
Choline is only required for cognitive properties when combined with Piracetam
 
I find that ketamine DEFINITELY mixes very well and intensifies the buzz.

If that's not around, a few percocets or some straight oxycodone will make you SOOOO euphoric.
 
Take Rolaids
4000mg Piracetam
500mg Choline
Vicks Stick inhaler on come-up
Lots of sleep
Orange Juice before and after

and most of the times thats a pretty bomb roll if your in a good mood / mindset with confirmed MDMA
 
My Opinion
How about this...
If you drink pretty often and you know your limit, to where you know when you get tipsy and start sobering up.
Drink, wait for sober, and then take the pill.

I done it and it works wonders for me, because alcohol is an upper for me, therefor it puts me in good mood, and then I pop the pills, and its damn awesome roll.

But that just works for me, unless someone else has tried, I dunno.
 
I don't know about grapefruit juice and mdma but let me tell you, DO NOT take grapefruit with MDA. Worst physical comedown ever. It supposedly stop the shit from breaking down( at least for mdma) but frankly not the way people think. It seemed to just let toxins sit there that should have been removed. You roll has to end, better to just accept this sometimes I guess. I have never felt so physically naseous after a roll. It seemed to just increase the body load with no extension of the euphoria.

That weird trippy feeling that kind of goes past the euphoria of the roll by about 1-3 hours went for another 5 hours and left me feeling sick as fuck the whole time wishing the damn thing would end
 
Isochroma said:
I've compiled a web page listing some amazing experiences people are getting using piracetam to potentiate MDMA and other drugs.

Some of the experiences are truly magical. Anyone who takes MDMA should be preloading with piracetam as it is the most validated, safest and cheapest potentiator in existence.
Click to expand...

ok, I'm a born skeptic and probably a lot of this is placebo effect, but heck it sounds like it's worth a shot!

My question: I have seen many shows/articles on supplements and how there are very shady companies that are not selling what they claim. Are there brands of pricetam that someone can recommend as being proven the real deal? (I'm in the US)
 
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I would also recommend Piracetam taken every day for a few days before you roll. If you're in the US look for supplier that will ship you 700 mg in bulk (you have to cap your own caps). They are legit and they seem to have the best deal.
 
Theoretically, it shouldn't matter; it's not like amino acid supplements that have to compete for metabolism and transport. I haven't found it to make much difference in any case. You do have to take it for a few days to build up a good serum level, according to rumor.

If you like the taste of battery acid, I recommend mixing it in with your choline supplement and orange juice and drinking it down. :) Otherwise, yes, caps are a brilliant idea, but the choline makes your fingers rather greasy if you decide to cap it as well.
 
Someone already mentioned it but it's definitely worth repeating...Green Tea Extract, or ECGC not only helps prevent neurotoxicity (as it's an EXTREMELY strong anti oxidant), but it also helps potentiate the roll. I take it right before I take my pill every single time.
 
Advanc3d said:
COMT Inhibitors,, MAO-B Inhibitors, and CYP3A4 Inhibitors are all available as a nutritional supplement


Quercetin acts as a Triple inhibitor, as it inhibits the above 3
Green Tea (EGCG) is a COMT Inhibitor as well as a decarboxylase Inhibitor.

Piracetam also potentiates nearly all stimulants.
Choline isnt required for this
Choline is only required for cognitive properties when combined with Piracetam
Click to expand...

So would it be safe to take Quercetin, Grean Tea Extract, and then MDMA? Is it more easier to overdose that way?
 
Well, COMT is used in one of the two pathways for metabolizing MDMA, so I imagine it'll make the MDMA resident and active for a longer time in your brain. I imagine inhibiting MAO-B would be less likely to cause problems, since it preferentially metabolizes dopamine, not serotonin. Finally, CYP3A4 inhibition may be problematic, as once again you'll have more serum MDMA hanging around for longer. If the presence of MDMA itself is neurotoxic, this and COMT inhibition could cause problems. It'll definitely influence the overdosing picture if you're talking about acute toxicity from MDMA itself.

Also, if anyone knows, is the remaining metabolic pathway after taking a COMT inhibitor any more likely to produce toxic metabolites? I'm out of my league. :\
 
Milk of Magnesia. (Its name in the UK, not sure what it's called in the US or Oz)

Drink half a bottle an hour before dropping. My limited understanding of chemistry suggests it neutralises a load of stomach acid, thereby creating a more neutral PH environment.

Anyway, it has ALWAYS increased the intensity and length of my roll.

And a very close friend who is a GP (family doctor) has also tried it and vouches for its rather incredible MDMA potentiating effects.

Have fun kids and don't forget your Milk of Magnesia!!!

(But also have some immodium [loperamide] handy because the Milk of Magnesia and MDMA combo WILL wreak havoc with your bowels...... but nothing 4 immodium can't handle!)
 
uacvax said:
dxm ? i think it's dangerous
Click to expand...

Combining DXM and MDMA can be extremely dangerous. Both DXM and MDMA rely on the same enzyme for metabolism (breakdown in the liver), and if you combine these two drugs, then they compete for the enzyme. As a result, either one or both of the drugs isn't broken down quickly enough, and a toxic build-up of that drug/those drugs occurs. In this particular case, the build-up of DXM/MDMA can lead to SEROTONIN SYNDROME, a very unpleasant set of symptoms than can be fatal. (Kreth K, Kovar K, Schwab M, Zanger UM. Identification of the human cytochromes P450 involved in the oxidative metabolism of "Ecstasy"-related designer drugs. Biochem Pharmacol. 2000 Jun 15;59(12):1563-71.)

In addition, DXM causes an increase in body temperature and when combined with MDMA it can lead to dangerous overheating. Furthermore, DXM contributes to diarrhoea and vomiting. This gastrointestinal purging can be a major contributing factor to hyponatremia. Both overheating and hyponatremia can be fatal. The dissociative effects of DXM might possibly cause a user to be less aware of the fact that bad things are happening to their body.

Avoid this combination by not taking multiple pills unless you have tested them and know the contents of those pills. Also, DXM is an ingredient in many OTC cold medications - check the list of ingredients. DXM will remain active in the body for 4-8 hours. If you have taken cough syrup earlier in the day, be wary of dosing MDMA until the DXM has left your body.

Lifted this from http://www.bluelight.ru/vb/showthread.php?t=79027.
 
dhcdavid said:
Milk of Magnesia. (Its name in the UK, not sure what it's called in the US or Oz)

Drink half a bottle an hour before dropping. My limited understanding of chemistry suggests it neutralises a load of stomach acid, thereby creating a more neutral PH environment.

Anyway, it has ALWAYS increased the intensity and length of my roll.

And a very close friend who is a GP (family doctor) has also tried it and vouches for its rather incredible MDMA potentiating effects.

Have fun kids and don't forget your Milk of Magnesia!!!

(But also have some immodium [loperamide] handy because the Milk of Magnesia and MDMA combo WILL wreak havoc with your bowels...... but nothing 4 immodium can't handle!)
Click to expand...


That is really interesting and would like to hear more about it.
I've heard so many people mixing their molly or crushed pills with orange juice, which would increase the acid in the stomach (which I thought would make it digest faster and hence more intense, but just guessing).

Anyone with more info on how this mechanism works and what should be ideal?
 
I've always heard the oj thing was just a myth, but most of my friends and I have always done it plus adding emergen c packets to it (1000mg of vitamin c). I think it's mostly a placebo type of deal for me. Plus all the prep before a night of rolling gets me in the excited butterflies in the stomach mood and I've always found that makes for a better roll. So regardless of factual evidence I will continue to do it. alcohol for me also helps in moderation. I like to drink a sparks or two while waiting for my lady to get ready (I have a extremely high alcohol tolerance). I think the slight buzz and caffeine contributes to the uplifted mood and excitement which is what really seems to be the best potentiator for me. I may start using 5htp as well because I've heard it helps especially if you plan on waiting a week or so for the next dose. However this was mostly from die hard raver e-tards that cannot really explain themselves or tell me where they got their info. Good luck
 
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