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Ecstasy Potentiation

>>SSRIs>>

To repeat, it is my understanding that SSRIs have greater affinity for SERT but cause less 5ht release, thus reducing or eliminating MDMA's effects.
...
Take with an antacid or two. Amphetamines and their derivatives, and opiates for that matter, absorb more readily in a more basic environment. Of course, plugging circumvents this whole issue...

ebola
 
i would not suggest using 5-htp right before or during your roll. For my friends and I it diminishes our roll for some reason. Of course everyone is different so it may not affect you that way, but from experience i learned not to take it 12 hours before and a couple hours after the roll. A good way to help your brain: 5-HTP, tryptophan, and fish oils.
 
Sprinklervibes said:
A low tolerance (tolerance is longterm and stays longer if you abuse it)
a fit, rested, well-fed body
good set& setting
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lol... you took the words right out of my mouth.. I am big on health, I workout regularly, eat healthy, take vitamins and the whole works and I always respond well to E!!

Set & setting are always a good factor too, but I find when im feeling nice off E any place is good for me.. could be just me though.
 
Kastr0 said:
Set & setting are always a good factor too, but I find when im feeling nice off E any place is good for me.. could be just me though.
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Nah I reckon thats pretty common.

On a side note, Kastr0, I havent seen you round the joint for ages.......welcome back.
 
The human brain only has so much seratonin that can be released, once you go past that point taking more pills, or any other potentiating methods, are just giving you a placebo high. There's nothing better than taking high quality pills in a manner with a high bioavailability, anything else is just trying to mimic the effects of a well-absorbed and great pill.

Peace and love.
 
GenericMind said:
Nope, Nootropics.

Erowid's Nootropic Info:
Aniracetam
Oxiracetam
Piracetam
Pramiracetam

There's also some good information here.
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I've had quite a bit of experience with pramiracetam. I don't recommend it, got very weird side effects that were not unpleasant but a bit of a nuisance. I've heard many people have success with piracetam though, and I haven't tried aniracetam or oxiracetam.

Personally I find a vitamin B complex does help quite a bit, but usually works best if you take it as part of a daily regimen in the long term.
 
nootropics did the trick for me. the first few times at least. doesn't seem much of a factor now...

someone mentioned tyrosine in another thread, which i've yet to try...
 
Trentonian said:
Marijuana. Large Amounts.
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Amen brother. I vaguely remember reading that THC and MDMA are removed from the bloodstream by the same enzyme so consuming both simultaneously makes each substance last longer than either would by itself. Can anyone confirm this or point me to an article?

atom_boy said:
i have read somewhere that taking a dose of L-tryptophan in place of a second pill will give similar results but is better for you. ill see if i can dig up a source for it otherwise dont take it too seriously
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Yeah, that's tripe. There's no way eating a dose of an amino acid like l-tryptophan would have an effect even remotely similar to taking more MDMA.

ebola? said:
>>SSRIs>>

To repeat, it is my understanding that SSRIs have greater affinity for SERT but cause less 5ht release, thus reducing or eliminating MDMA's effects.
...
Take with an antacid or two. Amphetamines and their derivatives, and opiates for that matter, absorb more readily in a more basic environment. Of course, plugging circumvents this whole issue...

ebola
Click to expand...
I have not had any experience with SSRIs and MDMA; but I am scripted to take two, 150mg doses of bupropion (wellbutrin) daily (it is a DA and NE reuptake inhibitor). Since I started taking the bupropion about 3 months ago I have used MDMA ~6 times. Two of those experiences (first and third) I kept up my usual doses of wellbutrin; the first experience I even took my PM dose of wellbutrin while I was already rolling. For the other four experiences, I stopped taking my wellbutrin about 48hrs prior to when I planned on rolling and did not take any more of it until a good 24hrs after the MDMA faded.

The results were interesting. Both times I maintained my intake of bupropion I still rolled hard; but once I was done rolling (normally by the next morning) my heart rate stayed abnormally high (140BPM-175BPM) while just sitting on a couch in a state of rest. I experienced over 48hrs of an uncomfortably elevated heart rate and an exceptionally prolonger wait to become tired after the first time I used MDMA while taking my wellbutrin. The effects were similar the other time I stubbornly took my bupropion despite my plans to use MDMA soon. I rolled hard, came down psychologically; but then I was kept awake for another day or so by a pounding, rapid heart beat and all around 'cracked-out' sensation that I never normally experience with clean MDMA.

I hated being layed-up all dizzy, weak, and frequently involuntarily twitching for a day or so after rolling. I figured the bupropion, as a DA/NE reuptake inhibitor, might have been causing my dopamine/norepinepherine/epinepherine levels to stay elevated long after the MDMA had worn off and causing the nasty side-effects. So now I create a window of time around the night(s) I plan on taking MDMA during which I skip all of my wellbutrin doses. Since I have put that plan into action I haven't experienced any of the nasty after-effects described above so I figure bupropion must have *some* interaction with the effects of ecstacy.
 
Sandbag said:
I have not had any experience with SSRIs and MDMA; but I am scripted to take two, 150mg doses of bupropion (wellbutrin) daily (it is a DA and NE reuptake inhibitor). Since I started taking the bupropion about 3 months ago I have used MDMA ~6 times. Two of those experiences (first and third) I kept up my usual doses of wellbutrin; the first experience I even took my PM dose of wellbutrin while I was already rolling. For the other four experiences, I stopped taking my wellbutrin about 48hrs prior to when I planned on rolling and did not take any more of it until a good 24hrs after the MDMA faded.

The results were interesting. Both times I maintained my intake of bupropion I still rolled hard; but once I was done rolling (normally by the next morning) my heart rate stayed abnormally high (140BPM-175BPM) while just sitting on a couch in a state of rest. I experienced over 48hrs of an uncomfortably elevated heart rate and an exceptionally prolonger wait to become tired after the first time I used MDMA while taking my wellbutrin. The effects were similar the other time I stubbornly took my bupropion despite my plans to use MDMA soon. I rolled hard, came down psychologically; but then I was kept awake for another day or so by a pounding, rapid heart beat and all around 'cracked-out' sensation that I never normally experience with clean MDMA.

I hated being layed-up all dizzy, weak, and frequently involuntarily twitching for a day or so after rolling. I figured the bupropion, as a DA/NE reuptake inhibitor, might have been causing my dopamine/norepinepherine/epinepherine levels to stay elevated long after the MDMA had worn off and causing the nasty side-effects. So now I create a window of time around the night(s) I plan on taking MDMA during which I skip all of my wellbutrin doses. Since I have put that plan into action I haven't experienced any of the nasty after-effects described above so I figure bupropion must have *some* interaction with the effects of ecstacy.
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Sandbag, thats really interesting information mate.

I also am currently on Wellbutrin, although here in Australia its called Zyban and is used as a stop smoking aid.

I also use 2 doses of 150mg pills per day, although mine are both taken first thing in the morning.

I have been thinking of trying to use mdma without stopping the zyban simply for experimentation and to provide me with some excellent first hand experience.

It will be interesting to see if my results are the same.

What sort of dose of mdma did you use and over what sort of period?
 
intravenous said:
The human brain only has so much seratonin that can be released, once you go past that point taking more pills, or any other potentiating methods, are just giving you a placebo high. There's nothing better than taking high quality pills in a manner with a high bioavailability, anything else is just trying to mimic the effects of a well-absorbed and great pill.

Peace and love.
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i dont agree, piracetam does bring magic back for some ppl, if piracetam doenst work for you aniracetam will:)
 
MazDan said:
Sandbag, thats really interesting information mate.

I also am currently on Wellbutrin, although here in Australia its called Zyban and is used as a stop smoking aid.

I also use 2 doses of 150mg pills per day, although mine are both taken first thing in the morning.

I have been thinking of trying to use mdma without stopping the zyban simply for experimentation and to provide me with some excellent first hand experience.

It will be interesting to see if my results are the same.

What sort of dose of mdma did you use and over what sort of period?
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Sorry,,,this post will be shit since ;ve been awakje since friday injecting/smoking meth and I threw two strong rolls on top of it at a rave last night. I just got homne about a half hour ago and I'm still so fucked up that I have fuzzy-wobble eyes, my heart rate is still all jacked up and I've got those electric-feeling muscle twitches and mild shakes.

The first time I used MDMA while on the wellbutrin I took 3 strong clean rolls (high MDMA content) from a very trusted source. I also ate a hit of DOI that night so it may invalidate the first experience. Either way, I ate two rolls with the hit of DOI at 8pm. Took my 3rd roll about 5hrs later.
 
Gldm said:
I've had quite a bit of experience with pramiracetam. I don't recommend it, got very weird side effects that were not unpleasant but a bit of a nuisance. I've heard many people have success with piracetam though, and I haven't tried aniracetam or oxiracetam.

Personally I find a vitamin B complex does help quite a bit, but usually works best if you take it as part of a daily regimen in the long term.
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i never found pram to do anything
where you getting yours from?
 
1. High grade chronic
2. Big fat N20 balloons
3. GBL/GHB (be very careful. Know your dose before)
4. K (little bumps if your out clubbin)
5. Quality soundsystem w/ DJ rockin some funky house beats.
6. That MDA pill you saved for the perfect time.
 
tadfish said:
i never found pram to do anything
where you getting yours from?
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No sources permitted as per guidelines.
Even though they weren't good for combining with MDMA we wound up using them on their own. Great for when you have a lot of stuff you need to get done around the house but don't feel like doing it. Also good for writer's block, which considering I write for a living is very useful.

I'm also a Wellbutrin user, coming up on 3 years. I found skipping my doses tended to make rolls less intensive, but I never got the bad after-effects other people have mentioned. The only time I had anything similar to that was when I got meth bombs.
 
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Gldm said:
I'm also a Wellbutrin user, coming up on 3 years. I found skipping my doses tended to make rolls less intensive, but I never got the bad after-effects other people have mentioned. The only time I had anything similar to that was when I got meth bombs.
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Gldm, did you ever try mdma without stopping taking the wellbutrim?
 
MazDan said:
Gldm, did you ever try mdma without stopping taking the wellbutrim?
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No, stopping the wellbutrin is a bad idea for me. I've had periods where I've run out and couldn't get my prescription refilled immediately. After about 5 days I start getting really run down and have a lot of trouble doing anything. I started taking it before I started taking MDMA, so I don't have a reference without it to compare.

P.S. Pramiracetam is still legal AFAIK and I bought it through legal and traceable channels with no problems. Are sources of legal supplements now prohibited too? If so I wasn't aware of that since I found that source in a post here originally over a year ago and have mentioned it in several posts before.
 
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