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ECig JWH in PEG or, More Polar Cannabinoids?

guitarplayerone

Greenlighter
Joined
Oct 1, 2010
Messages
1
Hello ::wave:: new member, first post.

I am interesting in vaporizing something along the lines of JWH018 in PEG or VEG. I have heard of it's solubility in alcohol to be slight, but i could do without the drunkenness or irritation of the lungs. The problem is that overall, the molecule seems to be very hydrophobic, so of course a nonpolar solvent would be optimal. However, this nonpolar solvent need be nontoxic.

Another condition i want to impose is that it should not be acetone or OH.

Looking at its structure, i suspect PEG would would even better than EtOH, especially if isopropyl seems to work to some extent as well.

But finally, the real solution would not just be to find some 'relatively nontoxic nonpolar solvent system'

The real solution is if there are any more polar cannabinoids out there. I'll be honest i haven't looked at all of the chemical structures of the various cannabinoids, but anything that can participate in hydrogen bonding, N, O, F, SO2 (lol).

Furthermore, the specific ecig i have (copper) could be adjusted for various temperatures, etc (i could just wire a resistor in there with various ratings, etc).

So the real question is: what's my best bet for a good solute/solvent system to stimulate those good ol CB1 and/or 2's?
 
Limonene/pinene/humulene/caryophyllene mix. They might be a little irritating to the lungs but are all naturally found in weed anyway and have reasonable boiling points and tox data.

Diglyme perhaps? n-heptane?
 
"Fat" Chance...

The real solution is if there are any more polar cannabinoids out there.

Given that the natural (endogenous) cannabinoids that our bodies make are derived from very long fats, its unlikely in my opinion that the CB1 or CB2 bind cannabinoids based on hydrogen bonding to any great extent. It's more likely that CB1/2 bind through steric limitations and hydrophibic interactions such as london dispersion and van der waals forces.

I would love to see them, but I frankly don't see much hope for a water soluble cannabinoid. I would really like to wrong though!!
 
The real solution is if there are any more polar cannabinoids out there. I'll be honest i haven't looked at all of the chemical structures of the various cannabinoids, but anything that can participate in hydrogen bonding, N, O, F, SO2 (lol).

There are, but not for sale.

http://en.wikipedia.org/wiki/O-2545

Basically 1',1'-dimethyl-THC with an imidazole on the end of the chain.
 
I would love to see them, but I frankly don't see much hope for a water soluble cannabinoid. I would really like to wrong though!!

Sweeeet! Based on the two comments above me I am wrong! Can't wait to see how these work out.
 
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