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  • EADD Moderators: Pissed_and_messed | Shinji Ikari

EADD Benzo Discussion V. I forget

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Got myself a rather nice script...all legit too =D

NSFW:
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knock said:
Not quite as simple as that. The half life is how long it takes your body to remove half of however much of a drug is in your bloodstream. So sticking with the (proposed) delorazepam metabolite of diclazepam, assuming it all gets converted immediately (which won't happen, but hopefully we're only off by a day or two), if you start off with 60mg in your bloodstream then, in the worst case (140 hour half-life), it's down to 30mg after six days. After the next six days your body removes half of 30mg so it's down to 15mg. After the next six days it's down to half of 15mg so 7.5mg. Six more days, 3.75mg. where are we now, 24 days later and you have 3.75mg in your bloodstream. It's an exponential decay:

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(the numbers here are nothing to do with benzo half-life, it's just the shape of the curve we're interested in)

In the best case (60 hour half life) it's down to 30 mg after 2.5 days, 15mg, after 5 days, 7.5mg after 7.5 days, 3.75mg after 10 days.

Now, the quoted half lives for benzos are given as ranges, like 60-140 hours for delorazepam, that's quite a big range, so obviously it varies quite a bit. And while that benzo is in your system, you're developing tolerance to it, which you'll do at your own rate. So it's pretty impossible to give an actual figure as to when you'll be "back to normal". Probably a bit sooner than somewhere between 10 and 24 days :)

Whether it's 60 hour half life or 140 hour half life will depend on your body, and maybe it varies a bit from time to time, depending on what other work your liver and kidneys have to do. (I'm no expert on this, this is a "lay opinion")
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Fuck a pond of ducks that's a long time!

Thanks for the info and excuse my ignorance but does that mean this will be in my system for about a month then max? Shit a dick!

Will this be hurting my body trying to process it all? It's such a mild thing that it doesnt feel like it could do that much mischief considering my prior drug intakes, but I'm a bit more sensible (I think) nowadays so it would be nice to know.

The thing is, my follow up question was going to be whether I should actualy consider doing these things more frequently. Apart from the odd person telling me "you look a bit fucked mate" I feel absolutely fine and have been more productive over these past couple of days than in months.

Health wise how does alcohol compare? If I combine alcohol and benzos is that just all round bad news for my liver and other essential innards, or if I take more benzos and only have a couple of drinks does it work out better in the end? I found about 6mg and a glass of wine felt amazing.

Also, for example. I stopped drinking all together, and only had a couple of benzos when I went out, would that be better for me than a couple of drinks.

I suppose the issue is that if its going to take weeks to leave my system I'm just gonna keep topping myself up aren't I? I've heard benzos arent as harsh on the liver and kidneys as booze but they must still have some negative effect?

In the meantime my misses has hidden the Diclazepam from me until I get more information. Probably for the best really.... just gonna have a couple of spliffs instead I think.....
 
.....so I picked up my script yesterday and was on the tube with nothing to read so i pulled out the sheet of directions and info on my teva 10mg diaz, it was fucking amazing , basically telling you what to take that potentiates it - even mentions grapefruit juice - it was really funny, i know it was HR but it was also a recipe to get the best out of yer pills.
 
Fellowed said:
Fuck a pond of ducks that's a long time!

Thanks for the info and excuse my ignorance but does that mean this will be in my system for about a month then max? Shit a dick!
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It means, if wikipedia is correct about diclazepam metabolising to delorazpem, and if it all converts fairly quickly (this seems unlikely, more likely only some will convert but who knows?) and if it's right on the half-life figures for delorazepam, and if you got 60mg into your bloodstream (which is probably a bit optimistic) then it will take up to 24 days to get it down to a (probably) inactive level,

Will this be hurting my body trying to process it all? It's such a mild thing that it doesnt feel like it could do that much mischief considering my prior drug intakes, but I'm a bit more sensible (I think) nowadays so it would be nice to know.
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Everything that causes your body work to detoxify is a load on your body; but benzos are generally pretty benign toxicologically. This one is not very much researched, so who knows? But, if I had to put money on it, I'd bet that you'll be OK.

The thing is, my follow up question was going to be whether I should actualy consider doing these things more frequently. Apart from the odd person telling me "you look a bit fucked mate" I feel absolutely fine and have been more productive over these past couple of days than in months.

Health wise how does alcohol compare? If I combine alcohol and benzos is that just all round bad news for my liver and other essential innards, or if I take more benzos and only have a couple of drinks does it work out better in the end? I found about 6mg and a glass of wine felt amazing.
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I would say alcohol is probably considerably worse than a benzo. Combined, probably doesn't make that much difference. More benzos, fewer booze is probably better for your liver. Your brain doesn't like benzos long-term, though. And benzos and booze = irrational behaviour though.

Also, for example. I stopped drinking all together, and only had a couple of benzos when I went out, would that be better for me than a couple of drinks.
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Better for your liver, in the short term at least, maybe, but you're a guinea pig, so who knows?


I suppose the issue is that if its going to take weeks to leave my system I'm just gonna keep topping myself up aren't I? I've heard benzos arent as harsh on the liver and kidneys as booze but they must still have some negative effect?

In the meantime my misses has hidden the Diclazepam from me until I get more information. Probably for the best really.... just gonna have a couple of spliffs instead I think.....
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Spliffs are probably not at all bad for your liver. Not so great for your lungs though, if you're using baccy!

Given the choice between benzos, booze and spliffs, or some combo, I'd probably go for... opioids and GBL :D But that's just me. And in truth I tend to go for benzos, booze, opioids, gbl and stims. And psyches and empathogens.

And dissociatives; always dissociatives.
 
mydrugbuddy said:
as i have pretty much blown out my tolerance to the hypnotic effects of etiz, and is why i take such big doses. It still delivers the anxiolytic effects about 3 years into daily use though, even just 1mg still does that very effectively, i find that quite amazing.
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Im sure that ive read that etizolam has a weird effect on tolerance, with regards to the fact that some of the effects actually increase in the medium term.

I feel like a prick now for starting that rc benzo post this morning now seeing as they seem to be the hot topic on here. As ive said ive got through a fair amount of pyrazolam, etizolam and diclazepam over the xmas period but I only had my first blast of flubromazepam yesterday. Considering ive heard nothing but good things 24mg at 11am seemed underwhelming to say the least but an extra 16 mg at 7pm seemed to finally get me where i wanted to be. I have 40mg left and have no money for heroin until tuesday so im going to save them for tomorrow night. Im sure a 40 mg dose should do the trick but they're so expensive I dont know if ill be able to get them on too regular a basis.
 
Visiting my parents for couple of days got pain clinic appointment.

Was chatting to my mum and she admitted back in the day when she was doing nursing she would take a moggy to get to sleep in preparation for working night shifts.

Which for my straight laced mum I found quite funny! But back then everyone was doing it!
 
mydrugbuddy said:
be carefull with that etiz Nicklazz, it would be incredibly easy to replace a PV problem with an etiz problem. It's hard to say which would be worse, but they could both be pretty fucking bad.
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yea you right MDB, I have had trouble with etiz before, long time before I met PV tho', but hell I am already thinkin of ordering more.. Aint good.

Had 50 on freday now I got 15. WTF have I done?!
 
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Nicklazz said:
yea you right MDB, I have had trouble with etiz before, long time before I met PV tho', but hell I am already thinkin of ordering more.. Aint good.

Had 50 on freday now I got 15. WTF have I done?!
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if it has only been a few days of using them it shouldnt be anything worse than possibly a little bit of rebound anxiety and insomnia. I think it is far better to face that now, as it should pass within a few days, rather than carry on using them for a longer period of time.
 
Ok so I seen so much conflicting info on what the best RoA for Etizolam as far as getting the most of of it is. Plugging, sublingual, buccal, just swallowing the damn stuff? Anyone got a definitive answer, or as a close to one I can get? I need my damn sleep tonight.
 
Oral is easily the best in terms of BA, duration, everything really.

Some people say sublingual comes on quicker and so 'hits them harder'. I'd say it's marginal at best.

I've never plugged etiz though. Must admit.
 
Oral it is then! Cheers guys. Unless knock comes in waving his syringe and differing facts ;) I've often plugged it but that was when I had a lot of spare cash and also I like sticking stuff up my arse but times are tight at the moment.

Honestly with the tolerance I have I think I enjoy the drug now more than when it used to get messy on a few mg. Just calm, optimistic, and hungry as fuck which is good cos I ain't eaten properly in over a week and lost about a stone.
 
Sammy G said:
That is pretty darn splendid really. I didn't know it was >95%.
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yeah, its a range ive seen quoted across several different articles, so i presume it's quite reliable. Etiz is proving to be a saviour for me. Its still delievring anxiolysis and mood lift 3 years into daily use at a dose of just 1 mg. This is quite phenomenal imo, considering how high i have pushed my tolerance i am amazed it still works at all. It is said that tolerance to the hypnotic effects rises first, and this does seem to be the case ime too.
 
Oh, I trust the figure implicitly. Just didn't expect it to be quite so bloody high!

As for etizolam as a 'saviour', I'd say I've seen definite benefits in my own life from having used it daily, but they've been completely offset by the negative aspects of benzo use in general and etizolam use in particular. Not least the potential for dependency that the perceived 'mood lift' brings to the table, the consequent rash decisions, the amnesia, rebound insomnia, crappy quality of sleep... you get the picture.

Though I know it isn't your intention to portray etiz as a 'saviour' in the context of your life in general, and that you're referring to the advantages of etiz versus various other, longer-acting benzos.

Pretty important to get that rant out of the way though, for the benefit of Ms Lurker, whomever she may be. :)
 
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