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  • EADD Moderators: Shambles

EADD Benzo Discussion v.5

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No not like those ones, they sound much nicer.
The ones I get are just normal pills, bigger than valium pills. Can't remember if they are made by TEVA or someone else but never seem to feel them really.
 
^^ truth (obviously)

The GABA receptors in your brain have been down regulated and this can take some time put itself right.

Any idea how long ? If i was tapering down to 0 over 6 months, would they be starting to right themselves during the taper, or not until complete absitinece, do you know ?

Sorry if thats kind of put you on the spot ;)
 
Any idea how long ? If i was tapering down to 0 over 6 months, would they be starting to right themselves during the taper, or not until complete absitinece, do you know ?

Sorry if thats kind of put you on the spot ;)

No idea and I've never read any estimates, I suspect you won't find much info and that even of you did it would vary from one person to another.

It is my understanding that many receptors in the brain work that way, I don't think mine have ever returned to where they were before a period of heavy abuse, but that it just my subjective opinion.

Whilst tapering I didn't notice any greater effect from the same dose, in truth once down to more reasonable levels if use (30-40mgs a day) I couldn't really discern any benefit. I think at least some of this is related to learn expectation of the effects during the earlier stages of abuse. I doubt anyone who had only used benzos therapeutically within a GPs dosage schedule would recognise the kind of effects you would have experienced with such high dosing.

I'd work on the basis that it will take many months to get back to anywhere near you were prior to this episode rather that get motivated by a false hope only to be disappointed. My GP is still trying to suggest my benzo abuse is a significant factor in my insomnia....I slept just fine on a couple of Xanax yesterday;)
 
Usually I just have my vallies at home to chill out with but today I had a job interview and I really felt the benefits of the vallies.
Normally I would expect to be nervous for an interview but I felt great, felt so at ease from the moment I arrived, all through my interview and tour of the premises.
Diazepam worked it's wonders for that type of situation just right.
 
Usually I just have my vallies at home to chill out with but today I had a job interview and I really felt the benefits of the vallies.
Normally I would expect to be nervous for an interview but I felt great, felt so at ease from the moment I arrived, all through my interview and tour of the premises.
Diazepam worked it's wonders for that type of situation just right.

Pretty much got me through any presentation/interview. Otherwise Id just stutter to fuck, go red and start pisssing sweat from most places. Used to have a few beers though before I discovered diaz in them situations.
 
No idea and I've never read any estimates, I suspect you won't find much info and that even of you did it would vary from one person to another.

It is my understanding that many receptors in the brain work that way, I don't think mine have ever returned to where they were before a period of heavy abuse, but that it just my subjective opinion.

Whilst tapering I didn't notice any greater effect from the same dose, in truth once down to more reasonable levels if use (30-40mgs a day) I couldn't really discern any benefit. I think at least some of this is related to learn expectation of the effects during the earlier stages of abuse. I doubt anyone who had only used benzos therapeutically within a GPs dosage schedule would recognise the kind of effects you would have experienced with such high dosing.

I'd work on the basis that it will take many months to get back to anywhere near you were prior to this episode rather that get motivated by a false hope only to be disappointed. My GP is still trying to suggest my benzo abuse is a significant factor in my insomnia....I slept just fine on a couple of Xanax yesterday;)

Right, so i cant reliably expect that if i taper off over 6 months to come out the other end all hunky dory. I can likely expect and should prepare for further problems.....

Surely a 6 month taper will have a far better outcome than a much shorter one though, even though even that is far from guarenteed to be plain sailing ?

How long is it since you defeated your dependence ?
 
Right, so i cant reliably expect that if i taper off over 6 months to come out the other end all hunky dory. I can likely expect and should prepare for further problems.....

Surely a 6 month taper will have a far better outcome than a much shorter one though, even though even that is far from guarenteed to be plain sailing ?

How long is it since you defeated your dependence ?

I doubt anyone could answer that, you would need to have accurately measured such things in a study group before and after.

I wouldn't get hung up about it, everyone is going to be different, like the 90 year old that's smoked 100 fags a day since she was 12 and can still run for the bus:)

It's just over a year since I finished the last taper, the most noticeable improvement in my memory and mood etc came within a month or so, the rest is too subjective, I function OK which at my advancing years is all you can expect.

I tapered at about twice the rate in the Ashton manual and stabilised my initial daily dose a good way under what I was taking randomly before. For me it was a balance between the pain of tapering and the pain of the drawn out process itself, I would have CTd if it was safe.

I think the fist thing is to stabilise your daily intake, that is a massive achievement in itself and gives you a good basis to take stock and plan your next move.

Plan out your taper properly so you can mark off the days, just planning it in your head isn't enough of a commitment IME, if you don't feel ready on the day to drop the dose then carry on on that dose for as long as it takes, but try really hard not to go back up, of you do try and make sure it's in a controlled manner rather than falling off the wagon all together.

Don't beat yourself up over this stuff MDB, self loathing is a dangerous thing and won't help. You seem to be genuinely improving from your posts, it's clear you must have drastically reduced your intake but it's also clear you are quite distressed and frustrated at the situation, lashing out at folk regardless of how you feel about their words won't help either ultimately it's in your hands what you decide to do but bets of luck with whatever path you choose.
 
Im past that lashing out phase. Ive just been talking to Sam about it iin the Mental Health Support thread. The fact that i can now see how aggressive, defensive & paranoid i was tells me that my state of mind has improved a lot since then.

I have been stabilizing and reducing my benzos for well over a month now, and have it all worked out - the 6 month plan. Im not gonna state my dosage (whats the opposite of increments ?) as everyone will laugh at me. But it is achievable and will get me there over 6 months, provided my doctor does not pull the plug on my Mirtazapine script. This is causing me quite a bit of worry at the moment so I need to get that straightened out with her ASAP.
 
Obviously I can't say for certain but I can't see why your GP would stop a script of a relatively benign AD that you feel is of benefit, just explain that you are anxious about this happening and I'm sure she will reassure you.

Generally they are keen for you to stay on the same AD for a good few months as many take that long to reach their full effectiveness, I doubt they will ever prescribe you something that will resolve all your mental health issues.

IMO ADs can provide some stability in your mood and prevent the lowest of the lows, giving you a chance to help yourself improve things, atm I know I'm better off on them, I can't tolerate the almost constant thoughts of suicide I'm getting without them.
 
Why do benzos make people aggressive? is it on the same level as booze aggression?
 
Why do benzos make people aggressive? is it on the same level as booze aggression?

Neither booze or benzos have ever made me aggressive, even at abusive levels but I'd guess the reasons, whatever they are must be related
 
Me neither, they always make me feel so good. i always get the impression they bring out the inner fuckface in people. if theres no fuckface to bring out then its pure love
 
GABA overworked --> less inhibitory action of the neurotransmitter.

http://en.wikipedia.org/wiki/Paradoxical_reaction#Benzodiazepines

http://www.medscape.com/viewarticle/489358 (Paradoxical Reactions to Benzodiazepines: Literature Review and Treatment Options, free acct needed)

And more reading:

NSFW:

Hall RW, Zisook S. Paradoxical reactions to benzodiazepines. Br J Clin Pharmacol 1981;11:99-104S.

Weinbroum AA, Szold O, Ogorek D, Flasishon R. The midazolam-induced paradox phenomenon is reversible by flumazenil: epidemiology, patient characteristics and review of the literature. Eur J Anaesthesiol 2001;18:789-97.

Short TG, Forrest P, Galletly DC. Paradoxical reactions to benzodiazepines: a genetically determined phenomenon? Anaesth Intens Care 1987;15:330-45.

Fiset L, Milgrom P, Beirne R, Roy-Byrne P. Disinhibition of behaviors with midazolam: report of a case. J Oral Maxillofac Surg 1992;50:645-9.

Strahan A, Rosenthal J, Kaswan M, Winston A. Three case reports of acute paroxysmal excitement associated with alprazolam treatment. Am J Psychiatry 1985;142:859-61.

Binder RL. Three case reports of behavioral disinhibition with clonazepam. Gen Hosp Psychiatry 1987;9:151-3.

Miwa LJ, Lobo BL. Midazolam disinhibition reaction [letter]. Drug Intell Clin Pharm 1988;22:725.

Goldney RD. Paradoxical reaction to a new minor tranquilizer. Med J Aust 1977;1:139-40.

Gardos G. Disinhibition of behavior by antianxiety drugs. Psychosomatics 1980;21:1025-6.

Regestein QR, Reich P. Agitation observed during treatment with newer hypnotic drugs. J Clin Psychiatry 1985;46:280-3.

Marchevsky S, Isaacs G, Nitzan I. Behavioral disinhibition with clonazepam [letter]. Gen Hosp Psychiatry 1988;10:447.

Khan LC, Lustik SJ. Treatment of a paradoxical reaction to midazolam with haloperidol. Anesth Analg 1997;85:213-15.

Rodrigo CR. Flumazenil reverses paradoxical reaction with midazolam. Anesth Prog 1991;38:65-8.

Honan VJ. Paradoxical reaction to midazolam and control with flumazenil. Gastrointest Endosc 1994;40:86-8.

Thurston TA, Williams CGA, Foshee S. Reversal of a paradoxical reaction to midazolam with flumazenil. Anesth Analg 1996;83:192.
 
I've managed to finish literally half of my alpraz script for the next two months in...a week. Ugh :(

I'm really annoyed cuz my GP wants to get me off xanax and put me on SSRIs instead...seems there's no way to get around that apart from quitting meds altogether. Shit system.
 
I need to chat to some people here. As it stands we are all gong to be ripped off. Talk to me and maybe we can sort that out. I talk of course of being ripped off of intellectual knowledge. Caring about the dangers of trying new untested shite.

I need some advice tbh. PM me your Skype address if you can help me out.

Regardless...Hope this new benzo is worth it!
 
Me neither, they always make me feel so good. i always get the impression they bring out the inner fuckface in people. if theres no fuckface to bring out then its pure love

Not true.

Lower anybody's inhibitions significantly in the way benzos can and the 'real' person is, to all intents and purposes, gone. Present them with a situation that elicits a reaction from them on the instinctive, animalistic level which exists below these inhibitions and totally uncharacteristic behaviour often results.

People are defined by their inhibitions to an extent.
 
Me neither, they always make me feel so good. i always get the impression they bring out the inner fuckface in people. if theres no fuckface to bring out then its pure love

Benzos are a bit paradoxical with rage/anger etc I've found. It's weird, sometimes they just seem to bring out the absolute opposite of what they're supposed to. I found that happens on higher doses especially...when I fucked up last week and took way too much etizolam I just turned into a monster for like 3 days, couldn't get a single emotion in me other than anger. It was very weird.

I can only help others now.Took plunge. Will be honest here if it turns out shite...or great etc.

?? :(
 
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