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Dysphorogenic drugs?

/navarone/ said:
No matter how many bad trips I've had though the worst feeling of my life was profound food intoxication from 'rotten' columbian psylocybe shrooms on an empty stomach after smoking a lot of weed.

Simple nausea can extend to a degree where your whole body is saturated with disgust, pain and terror. That time I was about to commit suicide cause I couldn't bare the pain and horror I was going through.

Nicotine overdose is also veeeery disphoric.

If I wanted to inflict a long lasting chemical torture to someone the requirements would be quite simple to find.
I was thinking about 3-400 mls of 70% alcohol + 1.5 grams of caffeine + 7 or more nicotine patches + a few 100mg of THC on an empty stomach. (I would throw in some Para-iodoamphetamine but that would almost surely kill him or her fucking up the whole intent).

Capsaicin injections would also be extremely painfull even if it has no psychological activity.
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Actually, correct me if I`m wrong, but p-iodoamphetamine should be pretty fun.

It`s the after effects one has to worry about.
 
thebaine? That's had me more miserable than anything else, thought I was dying for sure.

maybe thebaine plus butorphanol or a more selective kappa agonist
 
keops said:
Dysphorogenic drugs?

i was thinking of haloperidol + reserpine + naltrexone, all in ultra-high doses. also add MPTP if you want to make it permanent.

by the way, is there any lethal risk associated with dopamine suppression?

P.S. i'm posting this because of boredom and morbid curiosity, i'm not looking for any practical application.
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keops said:
yeah, but it's a rare side effect.

the point would be to inflict maximal torture (psychological eff. only) w/ minimal death risk.

again... this is just out of pure curiosity, i'm just a horror movie lover, not a real life psychopath.
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I'm slightly puzzled by the enthusiastic participation in this thread, considering what the OP asked for. And no, the disclaimer does not sound credible to me, in particular not when he has 3 posts and remains silent while the ADD-crowd is throwing ideas in, one after another.

Harm reduction? What was that again? Ah yeah, to inflict maximal torture, now I remember. My brain is already hurting a bit... :\

Seriously folks, where is your mind gone currently???


Peace! - Murphy
 
Only possible motivation: bicycle theft
...
TL;DR:
IV salvinorin A and strobe lights in a malfunctioning elevator for days
 
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Seriously folks, where is your mind gone currently???
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Would it make you more comfortable if we added our own disclaimers?

I PURSUANT TO THE INFLICTION OF PROPOSED HYPOTHETICAL TORTURE [AS DEFINED UNDER ARTICLE XX, SECTION 9000, SUBSECTION D, SUBSUBSECTION :p], THE INFLICTER (hereafter referred to as the Sadist) ASSUMES ALL RESPONSIBILITY FOR ANY ACTIONS, WHETHER ATTEMPTED SUCCESSFULLY OR UNSUCCESSFULLY, AND STANDS TO INCUR ANY LEGAL REPERCUSSIONS THEREOF AS PUNISHABLE TO THE FULLEST EXTENT OF THE LAW.
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III CONCORDANTLY, THE PARTAKERS OF DISCOURSE REMAIN SUBJECT TO THE AFOREMENTIONED STIPULATIONS OF THE MANAGERIAL STAFF OF BLUELIGHT.RU (all rights reserved); ANY REPERCUSSIONS RESULTING FROM A DIRECT VIOLATION OF SAID TERMS VIS A VIS THE USAGE OF ANY SERVICES PROVIDED BY SAID ENTITY ARE TO BE REGARDED AS UNALTERED BY ANY CLAIMS MADE WITHIN THE PRECEDING SECTIONS OF THIS DOCUMENT.

FORMALIZED COMPLAINTS REGARDING THE CONTENTS OF THIS DOCUMENT AND/OR ANY CLAIMS TO RESPONSIBILITY OR OWNERSHIP HEREIN, ARE TO BE MADE KNOWN EXCLUSIVELY TO THE MORALIZING OFFICES OF DR. MURPHY H. CLOX, ESQ.​
 
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I would recommend high dose melperone.

I once foolishly took some of that, not knowing what it was really (was younger then) and not even a very large dose. It gave me the most horrible feeling that I've ever had from any substance.
 
Akathisia is about as foul as it gets subjectively.

Alpha2 adrenoreceptor antagonists are the worst, the absolute fucking abyssal pits when it comes to that.

I got stuck on mirtazepine in jail once, a few years back, I took it once, got left with such awful akathisia I would have thrown myself out of the window, had there not been bars on it, I felt like I was trapped in my own skin with a nest full of wood ants.

Yohimbine would do it, that stuff has to be absolutely awful. I got very slight effects of that nature, the 'signature' sense of an A2 adrenoreceptor blocker from taking iporuru bark a few times, just enough that it gave me a lot of stimulation, and as a side effect, sexually...ahh..what is the word...whatever the devil the male equivalent of a nymphomaniac would be.

Any more though and I could tell it would be akathisia hell.

High-dose (100 to 200mg) promethazine did that to me once as well.

They say beta blockers and/or benzos are the best treatment for akathisia, but in my experience alpha2 adrenoreceptor agonists, parenterally or rectally, such as clonidine or tizanidine are by far the best method for dealing with it, followed by opioids, but the former much more so than the latter.
 
dread said:
I would recommend high dose melperone.

I once foolishly took some of that, not knowing what it was really (was younger then) and not even a very large dose. It gave me the most horrible feeling that I've ever had from any substance.
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Somewhat agreeing with you on that if it's similar to risperidone. Before I was diagnosed with HPPD my doc gave me risperdal for "the hallucinations". I didnt take it because pubmed said risperidone made HPPD worse, but I still filled out the prescription. I found another doctor and was successfully treated for the most part.

Anyway a year later my visuals had somewhat subsided so I figured, what the hey, I'll try one. Instant, 2 hour horrible acid trip for me. For everyone else they said it looked like I was a drooling zombie. When I fought through the panic and the visuals subsided, I felt like I had been lobotomised. I couldn't pick stuff up or hold my jaw in such a way as to not drip spit. Like a stroke all over. Plus I could feel "the fear". Funny enough my daily worries, during the remainder of the "trip" felt like distant memories but I was unable to do anything at all and just sat there feeling like shit.

They put my schizo aunty on the same stuff and she got a similar result (minus the involuntary acid trip). Just turned her into a retard basically. Eventually she learned to cope without the meds through CBT and home help. Atypical Antipsychotics are stupid in most cases, they trade delusions for retardedness. From what I can tell they are overused and designed to sedate rather than treat.
 
Limpet_Chicken said:
They say beta blockers and/or benzos are the best treatment for akathisia...
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I've always seen it treated with benztropine, an antimuscarinic.

ahh..what is the word...whatever the devil the male equivalent of a nymphomaniac would be
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satyriasis

You have bizarre reactions to certain chemicals.

I'm beginning to think drug-induced psychological dread is curable by cognitive training: sort of how one comes to talk himself through a bad LSD trip. Allan Watts in the 50s would dare Harvard researchers to feed him the strongest dissociatives known to them and would stay oriented to all spheres (so goes the anecdote).
 
Bizarre reactions? it isn't that bizarre, but D2 blockers and alpha2 adrenoreceptor antagonists do that to me.

D2 antagonists not so much, I have no problem taking upto 75mg promethazine, or on the occasions I have had to have shots of trifluoroperazine or its ilk for repetitive vomiting, had that after I ate most all of a roast chicken that decided to give me a case of something pretty hideous.

No problems there, nor with domperidone, or small doses of risperidone sufficient to retard nausea.

A2 antagonists on the other hand, ANYTHING with that property makes me really sick, akathisia which if not sorted ends up turning into myoclonus, and I am told, but do not remember it, seizures.

I can't imagine using yohimbine for sex, like some do, a torture aid, yes, but for 'recreational' use, jesus fuck no.
 
Wow I like how some of you people show your true sick sides, I didn't know we were trying to torture people here. As far as dysphoric drugs go, Salvia is a good choice, interesing psychaedelic but notable dysphoria, especially when you consider how unpleasant it makes tactile sensations. Makes your skin feel like ughhhhh. I tried butorphanol before, terrible opiate but I once had cool CEV's with it. Definitely anti-euphoric in it's own way. And hey, any drug cn be dysphoric in the right circumstance, eat a quarter of some super strong shrooms and go to work and (depending on your job) see what level of dysphoria you feel.
 
mCPP, anticholinergics(datura, diphenhydramine, etc), (higher dose)ephedrine/psuedoephedrine, antipsychotics(quetiapine, haldol, etc), oral methylphenidate, yohimbine...

just to name a few...
 
sekio said:
Subanaesthetic doses of dissociative drugs. For weeks and weeks at a time.
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Shit man... idk. Ketamine? Sounds f'ing epic to me. In fact I know a few people that have done just that. They're fine.

Bladder problems don't matter when you're deep in the hole ;)
 
I've tried recreationnal loxapine-->bad idea.
Everything was ok until I woke up monday morning. I'll never eat that shit again, I let it to the ones who really need it. I really felt bad, couldn't do anything without thinking how much that feeling was unpleasant.
 
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