Dysphorogenic drugs?

[keops]

i was thinking of haloperidol + reserpine + naltrexone, all in ultra-high doses. also add MPTP if you want to make it permanent.

by the way, is there any lethal risk associated with dopamine suppression?

P.S. i'm posting this because of boredom and morbid curiosity, i'm not looking for any practical application.

 

[MeDieViL]

Neuroleptic maligant syndrome can end lethal.

 

[keops]

Neuroleptic maligant syndrome can end lethal.

yeah, but it's a rare side effect.

the point would be to inflict maximal torture (psychological eff. only) w/ minimal death risk.

again... this is just out of pure curiosity, i'm just a horror movie lover, not a real life psychopath.

 

[atara]

If you want to torture someone with drugs, you'll have better luck with GABA antagonists (which cause convulsions) than dopamine antagonists (which cause anhedonia and akathisia). Or cholinesterase inhibitors, for that matter.

 

[MeDieViL]

High dose datura + high dose flumazenil + high dose naltrexone sounds like a good torture combo.

 

[seep]

the point would be to inflict maximal torture (psychological eff. only) w/ minimal death risk

you'd need to change the thread's title I think. For instance thyrotropine-releasining hormone (TRH) has profoundly antidopaminergic properties (I think), but it isn't torturous. By the same logic, a bioavailable formulation of prolactin would fit the bill.

---

One of the most torturous psychiatric medicines of the 20th century was insulin. Ever seen A Beautiful Mind? The scene where John Nash is writhing in agony in a mental hospital. Something like this.

 

[indelibleface]

Speaking of, I`ve always been fascinated by the idea of fluorothyl, a fluorinated hydrocarbon gas that is a GABA antagonist and causes convulsions. It was once used as an alternative to electroconvulsive therapy (another similar ECT alternative was pentetrazol - a regular drug, however, not a gas).

 

[Wizzle]

I'm trying them all out on my in laws right now.. Will report back

 

[seep]

Or cholinesterase inhibitors, for that matter.

cholinesterase inhibitors like donepezil (Aricept)? I've seen like 500 elderly patients on donepezil and they don't seem to mind it much. I've been thinking of combining it with piracetam for nootropic benefits.

 

[Slapdragonx]

Tardive dyskinesia is already permanent. After 6 months of being on risperidone (1mg) I have the beginning of tardive dyskinesia (the worm-like movement of the tongue). It is permanent, I have not taken risperidone in almost 3 months now, so the worm-like movements will probably never go away.

Granted the tongue spasms look pretty cool.

VMAT inhibitors might be what you are looking for. They basically deplete the dopamine, serotonin, and NE.

Tetrabenazine mainly depletes dopamine. Depression is a side effect in like 80% of patients IIRC.

 

[ebola?]

If you want to torture someone with drugs, you'll have better luck with GABA antagonists (which cause convulsions) than dopamine antagonists (which cause anhedonia and akathisia). Or cholinesterase inhibitors, for that matter.

The idea is NOT to kill the victim.

 

[skillet]

High dose JWH-018, or a serotonergic psychedelic, with a suitable choice of setting?

 

[sekio]

Subanaesthetic doses of dissociative drugs. For weeks and weeks at a time.

 

[atara]

cholinesterase inhibitors like donepezil (Aricept)? I've seen like 500 elderly patients on donepezil and they don't seem to mind it much. I've been thinking of combining it with piracetam for nootropic benefits.

No, cholinesterase inhibitors like sarin.

http://en.wikipedia.org/wiki/Organophosphates#Organophosphate_poisoning

Also yeah reserpine would be effective. So would a 5-HT2C agonist like mCPP.

 

[indelibleface]

I still don't get the whole mCPP / anxiety thing. I understand that its 5HT2C action should theoretically cause anxiety, and that it is considered a "panicogen," but having tried pure mCPP many times, I have to conclude that it's actually kind of fun, mildly psychedelic, and at best, an interesting diversion (but nowhere near classical psychedelics). I never felt anxious on the drug.

 

[seep]

My neighbor got fed potassium bromide in a Cuban mental hospital. He says he never experienced anything like bromism. I can't shake the curiosity of what the occasional pinch of KBr would feel like. Or even rubidium bromide.

I sorta just wanna make rubidium bromide. Actually I think I just wanna play with rubidium metal.

Subanaesthetic doses of dissociative drugs. For weeks and weeks at a time.

You'd run into tachyphylaxis after the 1st couple of days I think.

 

[Mudeltakappa]

I've contemplated this before. Seems to me a compound that antagonized mu and delta opioid receptors while acting as an agonist at kappa opioid receptors could be profoundly unpleasant.

 

[diche]

pentazocine. i used to get it in ampoules and take it IV/IM. dysphoria was very sensitive to dosage, increasing wildly. that and the eerie visuals

 

[melange]

salvia

 

[ebola?]

I still don't get the whole mCPP / anxiety thing. I understand that its 5HT2C action should theoretically cause anxiety, and that it is considered a "panicogen," but having tried pure mCPP many times, I have to conclude that it's actually kind of fun, mildly psychedelic, and at best, an interesting diversion (but nowhere near classical psychedelics). I never felt anxious on the drug.

mCPP is not a paradigmatic 5ht2c agonist but rather has numerous receptor-interactions. It is likely that 5ht agonism at other sub-receptors and serotonergic release act counterbalancingly anxiolytically.

ebola