Opioids DXM to control tolerance: Confused...

[CaliBoy90]

Alright so I searched for DXM and Magnesium to reduce tolerance, and I come across many posts saying to do the opposite of what I thought was the right one. I started to read how many people say that taking DXM and/or Magnesium AT NIGHT BEFORE BED will help prevent tolerance. Is this true? If so, that would be awesome. It would be awesome because whenever I take a low dosage of DXM (such as 15mg to 30mg) before taking Percocet, well, even the low dosage of 15mg DXM will completely change the Percocet. It will make it feel weird. I hate it. So it'd be awesome if taking it at night instead actually helped too, as anytime I take Percocet and DXM within a few hours of each other the DXM always makes the Perc feel weird and unwanted effects.

Although I'm confused how that would actually work though taking it at night.. How/why would taking DXM and/or Magnesium before bed help control either Amp or Opiate tolerance?? The only possible explantation I read from other posters is that it "resets" your receptors and "flushes/refreshes your NDMA receptors at night, which in turn helps prevent tolerance"... Is that true? There are countless people on multiple forums who claim that taking DXM + Magnesium at night is the BEST method.....

So what is the proper way? I sure hope taking it before bed would actually work because like I said even tiny doses of DXM completely changes the way Percocet feels/works and I hate it. Some people say taking the DXM extended release (Polistirex) BEFORE BED helps tolerance..True or no?

 

[Lorne???]

First off, no long term evidence proves exactly how effective NMDA antagonists are at reducing/preventing tolerance. Second, if it it does work/if your going to do it, b4 bed is just fine.

Remember, this is a CHRONIC regimen, not a one time thing.

If you do it, don't do it half-assed; take 30mg, every single night.

Who knows, if you stick to it, you might teach us something!!!

 

[Nicholai]

Well, it didn't work for me...

 

[CaliBoy90]

First off, no long term evidence proves exactly how effective NMDA antagonists are at reducing/preventing tolerance. Second, if it it does work/if your going to do it, b4 bed is just fine.

Remember, this is a CHRONIC regimen, not a one time thing.

If you do it, don't do it half-assed; take 30mg, every single night.

Who knows, if you stick to it, you might teach us something!!!

Yeah, I understand it's a daily thing and it's *believed* to work due to NMDA activity. My question still remains though:

WHY/HOW would taking it at night provide any benefit?? If you take DXM at say 1am every night before bed, then well, aren't you just inducing NMDA activity at night while you are sleeping? How would NMDA activity while sleeping provide possible tolerance benefits? The "NMDA activity" from the DXM would be worn off by the time you wake up, wouldn't it? So wouldn't that make it pointless?

As I thought you needed the DXM and the "NMDA receptor activity" to be currently active/working at the SAME TIME you take an opiate/opioid in order for it to provide any *possible* tolerance benefits.....