Dissociatives DXM Is Serotonergic PCP

[bigjackaal96]

At 450mg It literally feels no different stimulation wise but the Serotonergic part gives It effects not seen In other Dissos. It also a SNRI yet It dosen't feel like Ketamine + Venlafaxine. It far more warm & sunny in manner like shrooms, The cold/winter feel that Ketamine/Nitrous produce Is gone.

It nothing like what moderate to high dose Nitrous does so It not from very high D2 levels from NMDA antagonism. But It makes wonder If doing a SNRI with Ketamine or Nitrous would produce DXM effects?.

 

[Esperighanto]

But It makes wonder If doing a SNRI with Ketamine or Nitrous would produce DXM effects?.

Not sure if SNRI here is referring to "Selective" NRI or "Serotonin + " NRI, but I've been using Bupropion for a while which is predominantly a norepinephrine reuptake inhibitor. Well, it is when orally administered, intranasally it's much more dopamine heavy but I tend to just eat it since it lasts longer that way. I've mixed bupropion with almost every drug I've ever tried. With mixing it with DXM, it plays enzymatic trickery that really alters DXM's metabolism, and I've tried DXM without any bupropion in my system as well. Ketamine nor nitrous seem to be meaningfully affected by bupropion other than having a more clear headspace and more of a capacity to move and be aware, if that makes sense.

 

[bigjackaal96]

Not sure if SNRI here is referring to "Selective" NRI or "Serotonin + " NRI, but I've been using Bupropion for a while which is predominantly a norepinephrine reuptake inhibitor. Well, it is when orally administered, intranasally it's much more dopamine heavy but I tend to just eat it since it lasts longer that way. I've mixed bupropion with almost every drug I've ever tried. With mixing it with DXM, it plays enzymatic trickery that really alters DXM's metabolism, and I've tried DXM without any bupropion in my system as well. Ketamine nor nitrous seem to be meaningfully affected by bupropion other than having a more clear headspace and more of a capacity to move and be aware, if that makes sense.

Serotonin-norepinephrine reuptake inhibitor. It was a thought from If 400mg DXM can produce effects match strong shroom dose. Then a high sudden dose of Duloxetine + Ketamine would act the same, Since that aspect overlooked as many start doing DXM at 200mg+. There dumping out so much Serotonin that It hits the 5HT2A receptors that LSD & Shrooms do through brute force.

Bupropion closer to Ritalin a NDRI It more like PCP If mixed with Ketamine. I still view DXM & Bupropion makes them a SNDRI with mild NMDA effects which Is no different to what cocaine does going by It wiki page.