DXM and Dopamine

[(zonk)]

LOL MK-777 luv ur post... I can vouch for the cimetidine+dxm as not a good idea, never knew why but dxm never made me sick(unless i drank syrup)but with cimetidine i puked like crazy, didnt notice any intensification tho(probly due to sickness). And with Delsym I actually liked the lingering effects(like 24hrs+)but could never reach a hole(5th plateau)cuz i'd just end up blacking out, it's ALOT harder to find one's proper dose with that stuff.

I'd love to hear u elaborate on your DXO experience. By reading about it I always thought it would be similar to K in potency and effect and that the Erowid report may have been due to improper synthesis but if u got yers from Sigma then it was official. I thought maybe insuff or IV would be the way to go. What dose did u take?

P.S. Y does everyone flush their shit, if u don't like it maybe someone else will, such a waste and with all the sober kids in Africa...

 

[Epsilon Alpha]

DXM is like the sawn off shotgun of OTC drugs, wouldn't surprise me if did produce a increase in DA concentrations through an inhibition of inhibition type effect with some sort of NAChR and/or cation channel antagonism.

 

[strat54]

i get really euphoric at 350mgs dxm. i dont think it is really 'speedy' though, but I dont have too much stim experience.

 

[strat54]

DXM is a prodrug for detrorphan in vivo, and dextrorphan is a modest NMDA receptor antagonist. NMDA receptor antagonism upregulates dopamine receptors. This is what causes the increased ability to feel pleasure and motivation after coming down from a DXM trip. I've never heard anything about DXM increasing dopamine release during its peak of action, directly. It's probably minimal at best.

do you have a link? not because i dont believe you, i'd just like to do a little more reading.