Misc Duration of SSRI effects of diphenhydramine, and MDMA interactions

[phxt4life]

Hi all,

For several months up until about 2 weeks ago I pretty much abused diphenhydramine. Years back I tried tripping on it a few times, but that was not for me. More recently I began taking a few tablets nightly, albeit for its intended purpose this time, and saw a steady dose escalation to the point where almost every night I'd be taking upwards of 250-300mg.

Anyway, I recently stopped because I became aware of the SSRI-like effects of DPH.
Also because a few months back I had tried to roll on some MDMA I knew was good, and experienced absolutely ZERO effects whatsoever.
This was regardless of the fact that I had abstained from any DPH for about 2 days, although at that point I didn't know of the SSRI effects; it just seemed like a good idea.

My main question here is: How long should it take for these effects to diminish? I know DPH has a half life af 12-17hrs, but I also know prescription SSRIs can take many months for their effects to build up to intended levels, and I have been taking DPH for that long.

I enjoy rolling maybe 5 or 6 times a year and will gladly throw out the benadryl to preserve that, but I'm just trying to find out when it will be safe to try. (Rather not waste $$$ experimenting)

Thanks

 

[etro]

So from this post I'm getting that you think DPH is competitively binding at Serotonin receptors and knocking out the MDMA. In my experience, I don't think DPH is THAT strong of an SSRI or it wouldn't be over the counter in the states. I'd be very surprised if DPH stayed active for more than 72 hours, and as with almost anything 2 weeks should be enough to reset any and all effects. I have used MDMA and I take escitalopram afterwards to knock off the remaining MDMA from SERT when I want to stop rolling. I can usually roll again to some extent in a day or two. Maybe test your MDMA next time? Its unusual to not roll at ALL if its real. Stimulants tend to have the most consistent effects across demographics of any drug class I find. In all likelihood, back to the DPH, I wouldn't be surprised if it exerts a pharmacodynamic effect similar to phenergan, but with much lower binding affinities, which is mainly an antihistamine with some D2 antagonist action. Serotonin reuptake inhibition would be pretty limited.

 

[sekio]

DPH is not a high affinity SSRI and should not interfere with MDMA. Nor does it bind with high affinity to serotonin receptors.

 

[phxt4life]

Thanks. I would have thought it would just depend on the drug's half-life in the body, if it weren't for that one past experience. In any case I'm thinking it probably has been more than long enough at this point. Perhaps an *test* is in order...