L-amp peripheral effects via Adderall (D,L-amphetamine)
Crack cocaine- moreish as fuck, and low-quality these days; awful comedown
Lame, barely empathogenic RC's ie 5-MAPB, dull serotogenic and overly mongy-roll; might be good in combo w/ a proper psychedelic or dissociative.
a-PVP- kept me up for days, stim psychosis/mad paranoia came way quicker than say crystal.
MDPV/Mephedrone- in the form of "bath salts" worst comedown ever, crumbling depression and confusion/psychosis.
Some (JWH-xxx's for ex.) synth noids, except for AB-FUBINACA, love the indica-like couch-lock effects of being smacked and anxiolysis + slight visual psychedelia. JWH-018 causes major paranoia, anxiety, and dysphoria.
I hate buprenorphine, unless my opi tolerance is next to nothing or I'm using low-doses for a glow, mood-uplift, mild analgesia, and stimulatory/AD effects. Partial-agonists are so much "colder" than mu-agonists.
Lorazepam- such a boring/depressing benzo with retrograde amnesia at lower doses than one would hope.
MPH without any sedatives, for the awful crash esp insuffL ROA
Zolpidem- because it's hypnotic effects = shit (as well as duration). I had a script, abused tfo it via IV, now I can't feel it zolp at all.
Antipsychotics- ie quetiapine, horrible anticholinergic effects, awful RLS and zombie-like mood while being feeling weak and heavy physically.
SSRI's/SNRI's- causes awful, numb adverse effects for myself, as well as suicidal depression.
Tramadol on it's own, far too jittery for my tastes w/o a benzo + cannabis.
Dirty speed/m-amphetamine ie "Shake N' Bake" garbage- shit will make my body-ache like I have the flu during the comedown.
Amanita Muscaria- FAWKING BORING experience and weird.
25i-NBOMe- rough body load/come-up, visuals start to hurt my eyes because they become dull and the duration is far too long and there's no true, classic psychedelic depth or spiritual/deeply enlightening effects. Feels dirty and nothing valuable to be gained like LSD or Psilocybin/Psilocin provides.
Bupropion- very dirty, jittery stimulant DRI/AD, can provide a mood-lift, but the side-effects outweigh.
When you get fake MXE and it's actually 4-MeO-PCP/some strange disso-cutting agent like tiletamine, so you slam as if it were MXE and get instantly sent into a state of dirty, dissociative confusion and the motor incoordination is ridiculous at doses to achieve holes, lucid dreamlike hallucinations of situations that didn't occur, annoying residual effects, and little to no euphoria in comparison to K or MXE.
MDAI was completely useless as an empathogenic, almost no noticeable effect except a dull AD effect and uninteresting, warm, serotogenic glow.
DPH- because I grow tolerant to the sedative effects after 1-2 uses.
Hydroxyzine as an anxiolytic (great opioid potentiator though, one of my favorite antihistamines; alongside promethazine)
Xanax XR- only found alprazolam useful in IR formulations.
DXM's dirty, adrenergic side-effects, but love the stoning, dissociating metabolite DXO + cannabis = potentiation through the roof and long-duration euphoria. Oh yeah, and potentiating opioids with 1st plateau doses, ruins the rush/euphoria of even IV heroin; adds a dirty effect that dulls the high, despite increase in analgesia.
Flexeril- useless muscle-relaxant IME and uncomfortable, anticholinergic side-effects.
High-dose caffeine- far too anxiogenic/jittery
Nicotine while sober or on benzo's (decreases anxiolysis of most benzo's and peak plasma concentrations for alprazolam by 50%)
Fake E tabs- anxiogenic pipes, DXM, neurotoxic psychoactive drugs, unrecognizable/uncomfortable compounds
Cut-ass cocaine
Dibutylone- useless, dull effects with absolutely no euphoria/glow.
5-APB- can be a nice, flooring empathogenic with serotogenic warmth, but it's a tease overall and causes depression for me the next day.
Fake/degraded mushrooms- just a huge disappointment
Micro-dose LSD, uncomfortable side-effects (unwanted CNS stimulation/jitters) and "stuck in between" feeling outweigh the mild psychedelic experience; pretty much goes for any micro-dose psychedelic, I want the deeply spiritual, magic euphoria of a moderate-to-high-dose psych.
Codeine- just never got much from it, maybe I'm a poor metabolizer of codeine > morphine.
Diclazepam- very weak effects, no noticeable hypnotic or sedative properties.
New Opana ER formulation that ruined the almighty oxymorphone "stop-signs"; nothing better than railing a an old ER-formula 40mg octagonal tab or some 10mg IR's
Hydromorphone any other ROA other than IV is useless IME, now IV hydromorph is a godly rush.
OP Oxycontin bullshit-gel formulation (bring back the classic OC's!)
Phenobarbital- the most boring, easily obtainable anti-convulsant barbiturate in the US (usually used in detoxes/tapers)
Shitty quality kratom or under/over-dosage of kratom- (too much plain leaf caused vomiting, nausea, sweating, uncomfortable stimulation, dysphoria. Under-dosed kratom can be disappointing. I prefer the extracts/tinctures, UEI, high-alkaloid content strains like Maeng Da/UEMD, I aim for mu-agonist properties of mitragynine, 7-OHM (17-fold the potency of morphine), or semi-synthetics like mitragynine-psuedoindoxyl (mu and delta opioid agonism).