• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Drugs inducing neuro-regeneration

N

nevada

Greenlighter
Joined
Mar 21, 2010
Messages
38
which drugs, human made or natural occurring in plants and herbs, have neuroregenerating propreties?

as far as now, i've found research papers on:
Ginsengoides, ginseng
Ketamine (and possibly NMDA receptor antagonists) stimulates synaptogenesis
Cannabis, and CB receptor agonists
Ashitaba (Angelica keiskei). stimulates Nerve growth factor
Piracetam and AMPA receptor drugs
maybe Taurine, but probably has no direct effect on neurogenesis, but protect cells from radiation

do you know any?
thanks
 
Last edited:
Chronic fluoxetine has been shown to induce neurogenesis in the rat hippocampus. The effect was as potent as that seen with electroconvulsive stimulation. Full text. Tranylcypromine (a MAOI) also had an effect, but not as marked. I'd be interested in finding out if these results have been reproduced.
 
... said:
Chronic fluoxetine has been shown to induce neurogenesis in the rat hippocampus. The effect was as potent as that seen with electroconvulsive stimulation. Full text. Tranylcypromine (a MAOI) also had an effect, but not as marked. I'd be interested in finding out if these results have been reproduced.
Click to expand...

You are wrong on so many counts here. First of all did you read it?

Electroconvulsive therapy is much more potent in inducing neurogenesis and is the sole method which induces mossy fiber sprouting of the serotonergic fibers.

SSRIS do not increase neurogenesis in everyone and when they do in it pretty much only in one area which is lame, ECT does induce neurogenesis in everyone and much much more potently they are not even close to equal. lastly, SSRIS are not as efficacious as MAOIS in inducing neurogenesis.

BTW I would not rely on a single text for your info, alot of that text wasnt very good.


The most potent supplement by FAR for this is curcumin particularly the BCM-95 form of curcumin. Do some research on it, it does all you speak of and more, and is actually legit.

Fuck its much better than ssris and induces neurogenesis as robust as imipramine.
 
Last edited:
nevada said:
which drugs, human made or natural occurring in plants and herbs, have neuroregenerating propreties?

as far as now, i've found research papers on:
Ginsengoides, ginseng
Ketamine (and possibly NMDA receptor antagonists) stimulates synaptogenesis
Cannabis, and CB receptor agonists
Ashitaba (Angelica keiskei). stimulates Nerve growth factor
Piracetam and AMPA receptor drugs
maybe Taurine, but probably has no direct effect on neurogenesis, but protect cells from radiation

do you know any?
thanks
Click to expand...
I can vouch for ginseng.
Not only did it help get rid of my amphetamine psychosis in the days following the end of a month long speed binge,

but it seemed to replenish and restock my dopamine vesicles because I was actually able to get high off a low dose of speed a few days later =)

Where as vascular constriction from the speed would have normally just caused me dysphoria from trying speed again so soon after a month long binge had left me psychotic and in physical pain.
 
^I wonder if you walk around telling people "I feel like my dopamine vesicles are replenished"

Seriously though, does anyone have good sources for the claims about ginseng and taurine (the thing about taurine sounds dubious; pharmacologically it's mostly a weak glycine receptor agonist right?)?
 
If I'm high enough maybe

But seriously, I think ginseng helps get your dopamine system back in order after its been fried from an amphetamine binge -- this is just in my personal experience though and my own personal speculation.

Here's an article about how ginseng will completely block the effects of methamphetamine and cocaine:
http://journals.prous.com/journals/...mary_pr?p_JournalId=6&p_RefId=485635&p_IsPs=N

and another article about ginseng and methamphetamine/cocaine:
http://www.springerlink.com/content/g80176v1p1965t81/
 
Last edited:
the paper i've found on ginseng. this is quite useful if you're interested in ginseng pharmacology.
http://www.retrogenics.com/Ginseng__Pharmacology_1999.pdf
"Results from these investigations
suggest that ginsenosides may facilitate learning and memory
and are able to enhance nerve growth"
references 15 and 14:
Takemoto Y, Ueyama T, Saito H, Horio S, Sanada S, Shoji J,
Yahara S, Tanaka O and Shibata S, Potentiation of nerve
growth factor-mediated nerve fiber production in organ cultures
of chicken embryonic ganglia by ginseng saponins:
Structure-activity relationship. Chem Pharm Bull (Tokyo) 32:
3128–3133, 1984.
Salim KN, McEwen BS and Chao HM, Ginsenoside Rb1
regulates ChAT, NGF and trkA mRNA expression in the rat
brain. Brain Res Mol Brain Res 47: 177–182, 1997.
(Note: NGF is nerve growth factor)

about taurine, its just a speculation of mine. i've only found this paper, where the neurogenesis is promoted after irradiation. I could not find any study on healthy organisms:
Effect of taurine on neurogenesis in the dentate gyrus ofadult rat hippocampus after whole brain irradiation
http://en.cnki.com.cn/Article_en/CJFDTOTAL-SDYY200531012.htm
"Taurine can inhibit apoptosis immediately after irradiation.It can also promote neurogenesis two months after irradiation,which may be related to its beneficial effects in protecting neurogenic niche."
(Note: the niche is the protected envroinment where neural stem cells are dormient, and stay there until activated by NGF or other stimuli)
and this: http://onlinelibrary.wiley.com/doi/10.1046/j.1529-8027.2002.02011_4.x/abstract
Taurine counteracts oxidative stress and nerve growth factor deficit in early experimental diabetic neuropathy
where it says that taurine attenuates the NGF deficit in diabets. i wonder if taurine may counteract the deficit induced by other causes? (like opiates, stress, smoke... etc)

i've also found this, while re-searching the references above:
http://210.37.32.25/kns50/detail.aspx?filename=NTYX901.006&dbname=CJFD1999
A STUDY OF USING NEURONS CELL CULTURE TO SEARCH FOR THE EFFECT OF SINGLE CHINESE HERB ON NERVE GROWTH
In order to search for the Chinese medicinal herbs which can efficiently promote nerve growth,a hundreds of Chinese medicinal herbs were screened using neuronal tissue culture.The herbs able to promote nerve growth,such as schyranthes bidentata blume,cuscuta chinensis lam,atratylodes macrocephala koidz were obtained.the results provided scientific evidence for the study on the mechanism of Chinese herbs enhancing nerve growth.

its curious to see how all of these vegetal organisms beneficial to brain regeneration are from asia, no one from europe, americas or africa
 
Last edited:
^hey, cool: taurine is an apoptosis inhibitor

its curious to see how all of these vegetal organisms beneficial to brain regeneration are from asia, no one from europe, americas or africa
Click to expand...

I think they devote a lot more money to herbal research than we do. It's a cultural/Taoist thing.
 
neurogenesis is not always a good thing..........an IGF-secreting tumor can cause neurogenesis, and this typically does not turn out well......

its not the size per say......its a bit more complicated.......
 
negrogesic said:
neurogenesis is not always a good thing..........an IGF-secreting tumor can cause neurogenesis, and this typically does not turn out well......

its not the size per say......its a bit more complicated.......
Click to expand...

watch-family-guy-online-familyguylol-321.jpg
 
dont all neurogenesis based chemicals cause tumors eventually after a prolonged use ?
 
asecin said:
btw the best, well known neurogenesis source is already widely consumed:

http://www.ncbi.nlm.nih.gov/pubmed/16202182

:)
Click to expand...

yeah... but:
Moderate alcohol consumption and loss ofcerebellar Purkinje cells
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2540606/pdf/bmj00446-0017.pdf
"[...]The numbers and density of Purkinje
cells in the cross section of vermis showed a consistent
but weak decrease with increasing daily
alcohol intake[...]"

"[...]Conclusion-Long term intake of moderate doses
of alcohol daily for 20-30 years may damage the
cerebellum before the onset of macroscopical
atrophy. Despite distinct individual differences an
all year average daily alcohol intake of41-80 g results
in a risk ofsignificant loss ofPurkinje cells."

may be that alchool increases cells in a part of the brain and reduces cells in other parts, or maybe a different effect on different cell type
 
nevada said:
yeah... but:
Moderate alcohol consumption and loss ofcerebellar Purkinje cells
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2540606/pdf/bmj00446-0017.pdf
"[...]The numbers and density of Purkinje
cells in the cross section of vermis showed a consistent
but weak decrease with increasing daily
alcohol intake[...]"

"[...]Conclusion-Long term intake of moderate doses
of alcohol daily for 20-30 years may damage the
cerebellum before the onset of macroscopical
atrophy. Despite distinct individual differences an
all year average daily alcohol intake of41-80 g results
in a risk ofsignificant loss ofPurkinje cells."

may be that alchool increases cells in a part of the brain and reduces cells in other parts, or maybe a different effect on different cell type
Click to expand...


20-30 years.... if you actually consume alcohol regularly and live long enough, cant see any problem with this at all !
it does explain tho how a lot of people get inspiration from alcohol and drugs if not only changes perception but could cause neurogenesis as well. :)
 
this is one of the most complex solutions. what is moderation. every indifidual has a diffierent idea of what moderation of anything might mean. i guess it all comes down to personal experience, your own ideological perception and ability to judge correctly.
 
Why is neurogenesis desireable?

And why are Purkinje cells indispensible?

As for K - whatever it is that it does appears to be far more useful for "relearning" depression than life-extension, etc.
 
You must log in or register to reply here.
Top