I enjoy most games when stoned, though if I'm playing the likes of something like Dota or LoL or anything that requires teamwork and strategy I'll usually do absolutely shite - so I give those types of things a miss.
Gaming on MXE or any dissociative for that matter is out of this world. I went back and was playing through the original Half Life on MXE for a while, really felt like I was in the game and got me into the game even though it used to bore me when I'd played it sober originally (single player FPSes were never my thing).
On stimulants I play a lot of online poker but I usually later regret it, some players say it helps their game, and in heads up fast paced games it can help a little bit but in ring games or 6/9-max not at all.. and I usually end up wasting money when I do this.
On GBL I also enjoy online poker and it actually seems to improve my game - I think it's the combination of the dopamine stimulation and the GABA agonism that gets rid of my jitters and makes me make less of those rash impulsive decisions that stimulants sometimes induce.
I've not tried much gaming on opiates yet, a little chess which was fun but I found incredibly hard.. might try some other games though, feels like it could be a good combo as long as the action isn't too fast paced. Maybe a turn based strategy or something slow and creative like Minecraft/Gmod? I think RPGs could be pretty fun too, especially old ones that had deeper stories like Fallout 1/2, Arcanum, or Vampire: The Masquerade.
Benzos and alcohol I enjoy most gaming too, even if I play pretty rubbish most of the time whatever I'm playing.
Psychedelics make games feel unpleasant to me usually - feel like I'm wasting my trip.. though I can occasionally play a little.
Empathogens are usually the same as psychedelics, but if there's a lot of colours and music I can sometimes enjoy it. Games with a lot of teamwork usually go well with the empathy too, but not anything that relies on too much thinking. I enjoyed building stuff with my mates in Minecraft one time on 5-APB when I was stuck at home.