From the Physicians Desk Reference,
" Ketalar (ketamine Hydrochloride Injection, USP)
Clinical Pharmacology
Ketalar is a rapid-acting general anesthetic producing an anesthetic state characterized by profound analgesia, normal pharyngeal-laryngeal reflexes, normal or slightly enhanced skeletal muscle tone, cardiovascular and respiratory stimulation, and occasionally a transient and minimal respiratory depression"
As an anesthetic, it is usually given at dosages of 2mg/kg of body weight, (althought it is recommended at a slightly lower dose for higher risk patients) in conjunction with other short acting benzodiazapines, barbituates and a drying agent such as atrophine, scopalimine. It is especially well tolerated in children under 15 years of age and those over age 65, in part due to reduced respiratory problems.
My son then 9 or 10 broke his arm playing in the backyard. Once in the ER, when it was clear that it was not just a greenstick fracture and would need to be set was given about 30mg Ketalar IV, 5 mg Versed IV, and he also 5 mg of morphine IV already on board. The orthopedic surgeon waited about 5 minutes for it all to take hold and while he set my sons' arm, my son was verbalizing "Ouch, Ouuuch, aaaaaww" (well maybe not ouch!) in a very low voice, but not moving around. By the time the cast was on 20 minutes later and another xray done, he was coming around, and within a hour I could take him home. He is now in his first year of HS and does not mention his "trip" if he even remembers it. He does remember the pain prior to having his arm set and breaking it! I think this speaks volumes about Ketamines safety and efficacy.
If not for this relatively inexpensive method of anesthesia, there are many places in the world that would not be able to take care of some acute and emergent problems at a local level and the procedure would have to be put off until arrival a a larger regional hospital. This would cause undue and needless pain and suffering. I also have not experienced this drug myself, but that does not cause me any hesitation in insuring that my family not be caused any undue suffering and increased pain levels, which throughout history is why man has sought out ways to reduce pain through the use of plant and chemical analgesia.
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