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DRUG TOLERANCE: Proglumide and CCKa/b antagonism-The key to sensitization/tolerance

I actually found that in doses of even 10-50mg it weakened and spaced out stimulants.. I however was taking many nootropics at the time, but its odd that it seemed to dampen/space it out.
Most likely because of my current daily oxycodone dose, which in order for a proglumide effect to not be mentally depressive (via potentiation)must be lowered from 2.5mg to 1.25mg.

I believe it may reduce extraneous glutamate via a similar conceptual mechanism to that of GHB, or even affecting a cAMP mechanism, as proglumide potentiated quercetin that I was taking.
And unrelated but modafinil, quercetin, and oxycodone have extensive metabolic interaction, causing much of my daily data to be somewhat skewed.
BUt for opiate tolerance, take 200mg 30mins before your dose and cut your dose in half.

Another random thought is that proglumide may work by blocking epigenetic change in response to opiates etc, having taken quercetin lately a similar effect is prevalent, the euphoria is completely back..
To those who find this post by google via its SEO results, try quercetin 3x daily
 
for stimulant tolerance? maybe. possible rebound effect could come into play. but im not sure how long the glutamate reduction lasts and if its short term(such as 6 hrs after dose, or 36 hrs) I do not even have any more proglumide... for amph/modafinil/ritalin users i definitely suggest quercetin and uridine mono phosphate...
 
I've just acquired some of this stuff myself (thought I sincerely doubt the legitimacy of it)

If it actually works I'll probably write up a review, or add to this post etc.
 
update: I jumped the gun on saying I acquired it. Silly me for thinking the vendor I ordered from was legit (thought it could just be they went out of business and never took down the website, etc)
 
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After a bit more research etc, I have a source for it too.

I just wish it was a tad easier to get. The route I went requires a bit of digging and such, but yeah you're right it is out there.

Care to share your experience with it so far Vieno?
 
Unfortunately I can't comment on the effects because I don't have opioid tolerance. I bought it for another medical condition for which it proved to be useless but this doesn't mean anything, it was just speculation that it might work.

So I guess you just have to test it yourself :) share your experiences, I'm still curious even though opioid tolerance is not a problem of mine. I had to do digging too but well, now we've found the sources :) I'll PM you btw.
 
Yeah I'm still waitin (VERY ANXIOUSLY) for it to come in, heh.

My order should be going out on monday or tuesday.

I'll most definitely be sharing my experience when I finally do get it.
 
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