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  • N&PD Moderators: Skorpio | someguyontheinternet

Drug designs. (MedicinalUser SAR thread)

I call this one Orange-Goblin. Its molecular structure is 3-(3,4-dibromo-2,5-dimethoxyphenyloxy)-(2,5-dimethoxyphenyl)propane-1,2-diol.
 
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I call this one Bromo-DragonFLY-2.0. Its molecular structure is 4-bromo-2,3-furan-5,6,furanphenylpropane-1,2-diol.
 
I call this one XTC-2.0. Its molecular structure is 3,4-methylenedioxy-N-methyl-1-phenylpropane-1,2-diol.
 
I call this one Safe-Nova. Its molecular structure is 2-(3,4-bromo-2,5-dimethoxyphenyl)-N-[(2,5-dimethoxyphenyl)methyl]ethane-1,2-diol.
 
I call this one Diamond-TailFLY. Its molecular structure is 2-(4-bromo-2,3-furan-5,6-furanphenyl)-N-[(2,4-dimethylazetidine)methyl]ethane-1,2-diol.
 
I call this one Bromo-Dust. Its molecular structure is 1-(2,5-dimethoxy-3,4-dibromophenylcyclohexyl)piperidine.
 
I call this one Astro-Bro. Its molecular structure is 2-(2,5-dimethoxy-3,4-dibromophenyl)-2-(methylamino)cyclohexanone.
 
I call this one Bromo-Ami-FLY. Its molecular structure is Ethyl 3-[4-bromo-2,3-furan-5,6-furan-phenylethyl]imidazole-5-carboxylate.
 
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I call this one Sponge. Its molecular structure is Ethyl 3-[3,4-dibromo-2,5-dimethoxyphenylethyl]3-methoxy-imidazole-5-carboxylatepropane-1,2-diol.
 
I call this one Back-Water. Its molecular structure is Ethyl 3-[4-bromo-2,3-furan-5,6-furan-phenylethyl]3-methoxy-imidazole-5-caboxylatepropan-1,2-diol.
 
I call this one Bromo-Water-Strider. Its molecular structure is 4-bromo-2,3-methylenedioxy-5,6-methylenedioxy-2-benzhydrylpiperidine.
 
MedicinalUser247 said:
I call this one Back-Water. Its molecular structure is Ethyl 3-[4-bromo-2,3-furan-5,6-furan-phenylethyl]3-methoxy-imidazole-5-caboxylatepropan-1,2-diol.
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Have you ever thought about just editing your last post instead of posting 30x single sentence posts in a row?? Because technically youre spamming the forum and we've all talked about this and no one is happy about it.
Also you clearly have very little idea about SAR or neurochemistry. You can't just stick a methylenedioxy group onto a molecule and expect it to be psychoactitve. Pretty sure a lot of these can't exist, at least based on your naming. Are you drawing these and generating a name via a tool? Very few of these compounds are even indoles...
Smyth2 said:
Are you going to make any of these compounds or are only pursuing it for fun?
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kid just speculates, does not know chemistry at all, and most SAR chemists would never waste their time making 85% of these.
Hate to be mean, i just get irritated by incessant nonsense/garbage posts. It's a good thing I'm not a Mod in this forum.

@Skorpio back me up here?

http://www.swisstargetprediction.ch/

PLEASE go take a look at this site. You can either draw the molecules yourself or find the smiles code and input it. The website, while far from perfect, predicts binding of a random chemical to different receptor systems. You can also predict polarities, solubilities, maoi activity etc by clicking the little pill icon. It's an extremely useful tool. Please learn how to use it.

I would also recommend checking out: http://www.chem.uiuc.edu/GenChemReferences/nomenclature_rules.html
 
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I was wondering if I can interest anybody in my Etonitindole idea?
Etonitindole.png


Also I had the idea to generate the positional isomer with the sidechain occupying the indole nitrogen.

I'm fairly confident I have some knowledge on how it can be made based on a recent patent I saw.
 
Didgital said:
Have you ever thought about just editing your last post instead of posting 30x single sentence posts in a row?? Because technically youre spamming the forum and we've all talked about this and no one is happy about it.
Also you clearly have very little idea about SAR or neurochemistry. You can't just stick a methylenedioxy group onto a molecule and expect it to be psychoactitve. Pretty sure a lot of these can't exist, at least based on your naming. Are you drawing these and generating a name via a tool? Very few of these compounds are even indoles...

kid just speculates, does not know chemistry at all, and most SAR chemists would never waste their time making 85% of these.
Hate to be mean, i just get irritated by incessant nonsense/garbage posts. It's a good thing I'm not a Mod in this forum.

@Skorpio back me up here?

http://www.swisstargetprediction.ch/

PLEASE go take a look at this site. You can either draw the molecules yourself or find the smiles code and input it. The website, while far from perfect, predicts binding of a random chemical to different receptor systems. You can also predict polarities, solubilities, maoi activity etc by clicking the little pill icon. It's an extremely useful tool. Please learn how to use it.

I would also recommend checking out: http://www.chem.uiuc.edu/GenChemReferences/nomenclature_rules.html
Click to expand...
I allow molecule posts in this thread. The indoles name was because I merged a few threads.

I do reccomend reading the resources posted above.
 
Smyth2 said:
I was wondering if I can interest anybody in my Etonitindole idea?
Etonitindole.png


Also I had the idea to generate the positional isomer with the sidechain occupying the indole nitrogen.

I'm fairly confident I have some knowledge on how it can be made based on a recent patent I saw.
Click to expand...
Just by looking at it I can tell that the effect of that substance would feel like an opiate.
 
it's supposed to get around the legal barrier to creating etonitazene but there is the positional isomer also so 2 separate molecular entities to consider.
 
I've got another crazy idea trying to get closer and closer to designing a 5-HT2a super agonist. I've got one that's pretty close. I call it Double-Trypt. Its molecular structure is 4,5-dimethoxytryptamine-N-4,5-dimethoxytrypamine.
 
you're going to need a lab if you wish to pursue any of these ideas.

You brain is like a fountain of knowledge. Thanks for your contributions to healthcare.
 
I post this stuff so that chemist reading it will hopefully do the work. I wish that legal labs will use my information and go ahead and test it out. I would love to read about the effects of these substances that I design.
 
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