Drug designs. (MedicinalUser SAR thread)

[Deleted member 170540]

Here's a hybrid between PCE and ephenidine. No one seems to have done receptor binding tests with 1,2-diphenylcyclohexylamines

 

[MedicinalUser247]

Here's a hybrid between PCE and ephenidine. No one seems to have done receptor binding tests with 1,2-diphenylcyclohexylamines

I have some Designs of them in this Thread. It's great to see your Designing new ones. Thanks for posting.

 

[MedicinalUser247]

Have u heard of a drug called Perzinfotel?

I can't be bothered to dig up more phosphorus containing drugs but that one was in Lednicer's textbook 10-15 years ago.

What would you think about this one ? I call it Perzinfotel Analog X. https://ibb.co/BVHTPJ46

 

[MedicinalUser247]

I call this one Diphen-PCE. https://ibb.co/MDdMXmsn

There's more on page 71. Here's a sample of one of my Designs.

 

[MedicinalUser247]

I call this one 2C-MD-Dopa-Diver. https://ibb.co/k2vgNzQV

 

[MedicinalUser247]

I call this one Amfonelic-Acid-Ethylphenidate. https://ibb.co/27d4rrd9

 

[Smyth2]

Here's a hybrid between PCE and ephenidine. No one seems to have done receptor binding tests with 1,2-diphenylcyclohexylamines

2-Phenylcyclohexanone springs to mind because it is a precursor used in nexeridine synthesis.

I recently discovered how the precursor is made it's in this patent:

Andrew Carry KRUEGEL, et al. WO2021134086 (to Columbia University in the City of New York, Gilgamesh Pharmaceuticals Inc).

 

[MedicinalUser247]

I call this one 2C-Tetra-Chloro-Triphenyl-Ketamir. https://ibb.co/XfkKsr6y

 

[MedicinalUser247]

I call this one Di-TF-Modafinil-Dextro-Phenidate. https://ibb.co/QF1svjNK

 

[Smyth2]

I call this one 2C-Tetra-Chloro-Triphenyl-Ketamir. https://ibb.co/XfkKsr6y

The benzhydryl moiety reminds me of some other agents i have seen that are quinuclidine derived.

One of these agents was posted by Warawa. It is called 2-[bis(4-fluorophenyl)methyl]quinuclidin-3-ol.

[1] Warawa, E. J., Mueller, N. J., Jules, R. (May 1974). "Quinuclidine chemistry. 2. Synthesis and antiinflammatory properties of 2-substituted benzhydryl-3-quinuclidinols". Journal of Medicinal Chemistry. 17 (5): 497–501. doi:10.1021/jm00251a005.
[2] Edward John Warawa & Nancy Jean Mueller, US3506672 (1970 to Aldrich Chemical Co Inc).

 

[MedicinalUser247]

I call this one MD-137889. https://ibb.co/PZK73sV4

 

[MedicinalUser247]

I call this one 2C-C-2-137889. https://ibb.co/r2znpd7q

 

[MedicinalUser247]

I call this one 2C-B-137889. https://ibb.co/rG5bgQx6

 

[MedicinalUser247]

I call this one 2C-D-137889. https://ibb.co/VWRNTcps

 

[MedicinalUser247]

I call this one Mescal-137889. https://ibb.co/d0QNpsNx

 

[Smyth2]

I'm guessing you mean to take the logic from PD-137889 to come up with novel analog ideas.

 

[MedicinalUser247]

I call this one Thioscaline-137889. https://ibb.co/mrqFfZ50

 

[MedicinalUser247]

I'm guessing you mean to take the logic from PD-137889 to come up with novel analog ideas.

Your guess is Correct.

 

[MedicinalUser247]

I call this one 2C-CN-137889. https://ibb.co/KpLz7T8T

 

[MedicinalUser247]

I call this one 2C-I-137889. https://ibb.co/DPghDLWq