Drug designs. (MedicinalUser SAR thread)

[MedicinalUser247]

I call this one CN-Bow-tie-2. https://ibb.co/GfVkS046

 

[MedicinalUser247]

I call this one MD-Twister. https://ibb.co/m5bN1sfy

 

[MedicinalUser247]

I call this one CN-Twister. https://ibb.co/MkDr4G10

 

[MedicinalUser247]

I call this one Bromo-Twister. https://ibb.co/Xr5NkwBz

 

[MedicinalUser247]

I call this one I-Twister. https://ibb.co/C3X7Ns8s

 

[MedicinalUser247]

I call this one Methyl-Twister. https://ibb.co/hJXJhqk6

 

[MedicinalUser247]

I call this one Dichloro-Twister. https://ibb.co/pB6CmkD6

 

[MedicinalUser247]

I call this one TF-Twister. https://ibb.co/5WGHVvNT

 

[MedicinalUser247]

I call this one TF-HU-210-Analog. https://ibb.co/gbfs5Qjs

 

[MedicinalUser247]

I call this one 2C-G-5-TF-Norbornyl-Super-Date. https://ibb.co/2Yk2NZCM

 

[MedicinalUser247]

I call this one 2C-G-5-MD-Norbornyl-Super-Date. https://ibb.co/NfPRZ8h

 

[MedicinalUser247]

I call this one Early-Riser. https://ibb.co/sJRm5pt5

 

[MedicinalUser247]

I call this one 2C-GHB. https://ibb.co/1YfFFzJT

 

[MedicinalUser247]

I call this one Super-GHB-Metham-HOCPCA https://ibb.co/0yFgMXMN

 

[Smyth2]

This is my new design based on DOT:

PubChem

PubChem is the world's largest collection of freely accessible chemical information. Search chemicals by name, molecular formula, structure, and other identifiers. Find chemical and physical properties, biological activities, safety and toxicity information, patents, literature citations and more.

pubchem.ncbi.nlm.nih.gov

I decided to take another look at this with a view to how it is actually made.

I came up with the following patent: WO2015151490.

If you see reference example 1 that takes you to an ester that undergoes saponification and decarboxylation.

There are various methods for which an aromatic can be converted into a benzaldehyde. Gattermann–Koch reaction for example.

Category:Formylation reactions - Wikipedia

en.wikipedia.org

 

[MikeyNance1991]

applying the amfecloral moitey to 4fa, a prodrug of 4fa and chloral hydrate:

Screen Shot 2026 05 26 at 3 28 53 PM hosted at ImgBB

Image Screen Shot 2026 05 26 at 3 28 53 PM hosted on ImgBB

ibb.co