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Opioids Drug delivery with Nebulizer

The Young Geezer said:
Just tried this with about 250mg cocaine dissolved in 2ml of nebulizer solution (denaturalized water) and had to say it worked amazingly!!!! It can't compare to crack or IV coke, not even insufflation, since my nebulizer stops automatically after 5mins I need 3 nebulizations (more than 20 mins) to do it, and Iended up with a a few drops of the solution not being nebulized...The euphoric upper high is here in full effect but without it's edge, whichis an amazing thing, but I took a hefty dose of bupe tramadol and benzos today......was trying to see if I could extract a bupe patch into water and try it this way???

Generally I used 35% alcohol and warmed the container with the strip opf patch and solution for a while, let it sit for a couple of days and use the liquid will report... do you think to extract bupe from the patches and nebulizing it will work??? Well I'll report back.

I have some Tramadol Ampoules from ages ago I never used.....hmmmm might be interesting, and midazolam, can't wait for nebulized midazolam!!!!!!


Some questions.

Is it safe to nebulize a solution that has ISA on it, on a maximum level of 35%?
Do the drugs used in the nebulizer need all to be water solluble diluted in water? or say could I dilute flunitrazepam or bromazepam in propylene glycol and nebulize that?
I have an ultrasound nebulizer with the special chamber for the solutions and on the manual it says putting solids is a BIG NO, so I gotta dissolve the drugs, but it also says that using any medication not made for nebulizing may cause malfunction....well the coke worked like a charm, I'm gonna try tramadol bupe zolpidem and midazolam soon, and would appreciate ideas on how to prepare other drugs like Codeine for example, wouldthe results of a CWE work or would I have to further dilute it in Milk?? Guess for Cannabis Milk (Bhang) would be the way to go for nebulization.

Well if anyone had tried out some of this drugs or others and come up with efficient ways to dilute the drugs for them to work properly on an ultrasound nebulizer (I think it'd be the same for a Piston one as well, maybe times would change) please share your knoweledge!!!

Oh I can make the fumes come as hot or cold vapor in my nebulizer, I left the switch as it was which was hot, dunno if that makes any difference.

Great topic!!!
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did u ever try any of those things out?
 
This sounds like an extremely viable method, and my god am I interested. Considering its mixed into a mostly homogeneous solution, it should work beautifully.
Just one hitch though, it seems to take a while to actually finished off 2cc's of albuterol and some vapor always escapes. Maybe .5-1cc w/ like 2-4mgs to start with mixed in SALINE, like albuterol.

In EMS, as a last resort meds can be injected straight down your endotracheal tube but you need 1/5-2X the dose; and is now frowned upon as a method because of its dangerous complications. Basically controlled aspiration. Nebulizing more meds sounds like a new step in emergency medicine. PLZ LET US KNOW HOW THIS GOES!

edit: i see now that you did, fantastic! but what about that dill-icious rush? maybe less volume next time?
 
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I get quite a rush when I snort these when I used too, and it felt about like that. pretty pleasant. I don't IV so I can't comment on that rush.

Yeah, it was like 10-20 minutes of vigirous inhalation for sure. It's probably the most physically demanding method of drug delivery i've ever tried. Good though.
 
muvolution said:
I think you are trying to nebulize too many things. I would say no way to Codeine because it causes pulmonary edema when Iv'd so I would imagine sucking it directly into your lungs would be a shitty idea as the oral BA is already nearly 100%. Same with Tramadol, Midazolam, Ambien, etc...

This worked for me because the oral/ intranasal/ rectal BA of hydromorphone is so low in comparison.
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Midazolam is not that potent to begin with; it is - but if you have any kind of benzo tolerance, it just won't work well IMO. With tolerance - the potency is lost, to the point where just 1mg or 2mg isn't probably going to be adequate this way.

muvolution; what is your estimated dosage with this ROA?
 
My pharmacy dispenses powdered Fentanyl to be combined with sterile saline for nebulized delivery almost on a daily basis to hospice patients. It is possible, and effective. I can't tell you off the top of my head what kind of dosage you would need/want though.
 
Yeash, Probably 16mg in Solution, and ended up with .5mL of solution left, so that's 12mg, and that felt about like eating 32-40mg
 
i love this topic as I too do not IV/IM/SC. If this delivery is better than plugging I may have a reason to get HM again. I wasn't too impressed with 4mg plugged for what I paid, I barely got a buzz. How long did the effects last and what is your usual dosage rectally and/or nasally?

edit: Ive been Googling quite a bit on nebulizing Oxymorphone and have not been able to find anything for the life of me. I'm guessing that if I can somehow extract the Oxymorphone from the TimeRx successfully with the isopropyl alcohol method (crosses fingers), I can add 2 ml of water, and nebulize at .25ml per minute taking approximately 8 minutes to receive a 5-10mg dose of Opana depending on how well the extraction worked but i can estimate that my dosage would be somewhere around 1mg/minute. I bet that if morphine and hydromorphone work well with a nebulizer than Oxymorphone sure as hell will. I wonder what the bioavailability of it is, and if it would be even worth it or if it would be dangerous.

Morphine nebulized seems to have about 5 times less bioavailability than oral from what I've been able to read tonight except for one link that amapola posted but that was about a prototype AERx delivery system that when I scanned I didn't see anything nebulizer related but I have been wrong plenty of a time before. Hydromorphone has a bioavailability of about 2-4x the oral ba according to muvolution meaning it runs from anywhere to 60% to 100% BA when administered via nebulizer which is just about what certain sources on bluelight say rectal is, 60-90%, though I'm quite sure it's more around the 60% area for rectal. Either my searching is terrible or I can't find much on nebulized hydromorphone except this which doesn't say much.

Seventeen patients received nebulized hydromorphone, 1 mg q4h. While nine of these patients required further titration, one of the nine patients required a maximum of 20 mg q4h.

http://chestjournal.chestpubs.org/content/125/2/691.full
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Now that's a very vague two sentences if you ask me.

Anyone have a clue about how Oxymorphone will act when nebulized? With morphine being 5x weaker and hydromorphone being 2-4x stronger I've gotta say I'm pretty confused. Speculation is encouraged, it doesn't have to be from a medical journal or anything, just help me hypothesize with a little of the knowledge you guys have to share.
 
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ive tried this with liquid oral morphine when i was prescribed it (10mg/ml) and i didnt find it to effective, plugging it done a better job imo.
 
drzoidbergphd said:
i love this topic as I too do not IV/IM/SC. If this delivery is better than plugging I may have a reason to get HM again. I wasn't too impressed with 4mg plugged for what I paid, I barely got a buzz. How long did the effects last and what is your usual dosage rectally and/or nasally?

edit: Ive been Googling quite a bit on nebulizing Oxymorphone and have not been able to find anything for the life of me. I'm guessing that if I can somehow extract the Oxymorphone from the TimeRx successfully with the isopropyl alcohol method (crosses fingers), I can add 2 ml of water, and nebulize at .25ml per minute taking approximately 8 minutes to receive a 5-10mg dose of Opana depending on how well the extraction worked but i can estimate that my dosage would be somewhere around 1mg/minute. I bet that if morphine and hydromorphone work well with a nebulizer than Oxymorphone sure as hell will. I wonder what the bioavailability of it is, and if it would be even worth it or if it would be dangerous.

Morphine nebulized seems to have about 5 times less bioavailability than oral from what I've been able to read tonight except for one link that amapola posted but that was about a prototype AERx delivery system that when I scanned I didn't see anything nebulizer related but I have been wrong plenty of a time before. Hydromorphone has a bioavailability of about 2-4x the oral ba according to muvolution meaning it runs from anywhere to 60% to 100% BA when administered via nebulizer which is just about what certain sources on bluelight say rectal is, 60-90%, though I'm quite sure it's more around the 60% area for rectal. Either my searching is terrible or I can't find much on nebulized hydromorphone except this which doesn't say much.



Now that's a very vague two sentences if you ask me.

Anyone have a clue about how Oxymorphone will act when nebulized? With morphine being 5x weaker and hydromorphone being 2-4x stronger I've gotta say I'm pretty confused. Speculation is encouraged, it doesn't have to be from a medical journal or anything, just help me hypothesize with a little of the knowledge you guys have to share.
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the only way you're pretty much going to get a bang for your buck is if you decide to bang.. HM and OM are sought after for the rush they produce. if plugging them isn't getting your rocks off, don't plan on expecting too much from nebulizing.
 
Plugging is fine. Even snorting is fine, I do that most of the time anyway. It's just that if nebulizing is equal to plugging I'd do that instead with a certain 6 oz portable nebulizer. Why rail it all the time and ruin my nose or it could be just for the fuck of it every once in a while, why not. It's the opiate version of the vaporizer, expensive and unnecessary but nice sometimes. Then again i may be too fuckin stoned right now.

It's also helpful because it's just a nebulizer, I don't think that's considered paraphernalia and you can do it in public if you work in an office or something at your cubicle or if you're a college student you could be just administering your asthma meds for all they know. That's all dependent on whether or not opana has a high bioavailability when administered like that. i know i probably made the least sense possible, but it kinda is 420 give me a break.
 
Yeah, I'm stoked on this. It's kinda big and bulky, but now that I'm living alone it is nice to use. I try to only put in a little solution at once, beacause it isn't uncommon for me to nod off on like 4-8mg like this and you wake up and all your shit is boiled off. I've been looking into atomization syringes lately also.
 
they have portable ones that hold 3ml of medicine and fit in your hand for less than 200 bucks.
 
I can't believe this thread died! I came here to report what I thought was my discovery that nebulizers could be used for more than just asthma meds. At least I can announce that "ultrasonic nebulizers" can be had on ebay for just no prices now - small, plug-in units anyway. It's amazing what comes out of China these days.

I'm only starting to experiment, but I'm seeing lots of room for improvement in optimizing the aerosol density and thus the rate of drug delivery. If we can't discuss brands, is there at least a best kind as far as maximizing the delivery rate?

What I'm excited about is the use of the nebulizer for RCs like MXE, but that deserves a separate thread.
 
I would rate it as somewhere betwwen plugging and iv with a decent rush. I ruined mine by leaving it on, but they are easy to come by
 
There is an extensive wiki article on this, but it is focused of the morphones, specifically hydromorphone, beacuase it has the same molceular weight at morphine, but 8x potency, so it should be (and is) extremely effective.
 
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