• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Droxypropine

Ham-milton

Ham-milton

Bluelighter
Joined
Jul 20, 2007
Messages
5,738
I'm trying to find *anything* about this chemical. Very little is available, aside from Wikipedia clones- and wikipedia has scant on it.

220px-Droxypropine.png


Looks like it might be enjoyable if you're into that sort of thing- which it just so happens I am!

It doesn't appear to be explicitly scheduled, but I can't imagine it not being considered an analogue of ketobemidone, unless it's been approved for use in the US. Has it?

edit: I'm not a chemist, and I don't pretend to know a hell of a lot about the chemistry involved in these drugs, but this would probably turned into Ketobemidone easily enough, huh?
 
That chain would be difficult to remove? Shows how much I know about that side of things.

Could be better? I don't know much about this series of opioids
 
You might be able to get it off just with acid, chloroformates apparently also work but have to be removed after. Then you have to methylate the amine without getting the quaternary ammonium salt.

How about this, mechanism looks ok, easy (fairly) chems. Weather it will actually work i dont know.
 

Attachments

  • untitled.gif
    untitled.gif
    3.1 KB · Views: 119
Would be hard to predict something like that, in such a strong base it seems like the hoffman elimination might be a candidate also?

I like that though, kinda got a pseudo-stevens rearrangement, is there a name for that specific reaction?
 
Get the chain off and then some reductive amination magic to get what you want - you might be able to do it with Zn/HCOOH & formaldehyde (one-pot).
 
Thats why i put NaH, non-nucleophilic base. Dunno if theres a name or if its similar to something else, just tried to think of a way to replace that thing with a methyl easily.

Edit: oops, it doesn't matter if its non-nucleophilic does it! but it'll deprotonate the alcohol quickly and non-reversibly so it should be ok.

Matt, how do you suggest to get it off? Acid?

Ketobemidone also has a meta-phenol, which is not gonna happen! Dont know how much difference it would make.
 
Last edited:
Ham-milton said:
I'm trying to find *anything* about this chemical. Very little is available, aside from Wikipedia clones- and wikipedia has scant on it.

220px-Droxypropine.png


Looks like it might be enjoyable if you're into that sort of thing- which it just so happens I am!

It doesn't appear to be explicitly scheduled, but I can't imagine it not being considered an analogue of ketobemidone, unless it's been approved for use in the US. Has it?

edit: I'm not a chemist, and I don't pretend to know a hell of a lot about the chemistry involved in these drugs, but this would probably turned into Ketobemidone easily enough, huh?
Click to expand...


Looks vaguely like Etoxeridine....

EDIT:
It's the same except for the ester linkage in etoxeridine.
 
Last edited:
The only thing that immediately came into my head was meperidine, with the "tail" of quetiapine.

Actually, I just noticed its keto and not ester. It looks like a drug all right!

I dont really see how this is a question that requires an answer.

You clearly dont have a supplier who can sell you this?
 
Last edited:
Smyth said:
The only thing that immediately came into my head was meperidine, with the "tail" of quetiapine.

Actually, I just noticed its keto and not ester. It looks like a drug all right!

I dont really see how this is a question that requires an answer.

You clearly dont have a supplier who can sell you this?
Click to expand...


......
 
i suppose this compound would be mainly a nmda-blocker along with a strong mu-opiate-agonism.
in which country is it sold as an antitussive, does anyone know that?
 
Are you sure about the NMDA antagonist thing? I think ive read about methadone being one, and possibly also ketobemidone, but I dont know about strength. For instance, sertraline is a potentish DARI (25 nM) in vitro. However it's SERT affinity is subnanomolar so for all intents and purposes it behaves as an SSRI.

In response to F&B, there are quite a few people who have seriously cut-back on their post count, not because they have no interest in drugs. The reason is that they dont see the purpose in talking about stuff just for the sake of it. The molecule is not available commercially, and nobody has the ability to lay their hands on it. Therefore of what real-world significance is it other than giving people something to babble about?

It just seems utterly pointless without any literature to back it up with to post the structure of a molecule (usually just a half-assed sketch in chemdraw) and say "here, what do you think of my "discovery" guys? I have no way of making this in a lab but somebody should do, and then I will take all of the credit for this great idea ;)" This is more in cases where the guy posting the molecule/s has no formal knowledge of chemistry and is posting structures of stuff without the first clue of how one would go about making them. In such cases it seems totally amateurish. But in credit to the thread poster, at least in this case the molecule actually has been made and is not just pie in the sky.
 
Last edited:
^ If no-one speculated, then nobody would bother being adventurous. I remember speculation about desoxypipradrol long before it became available; without that speculation, it probably wouldn't have become available (whether that is good or bad is another issue altogether).

As I recall, you've speculated enough in the past...
 
though usually most substances have had some readily correlatable SAR inferences or some degree of journal material elaborating on them

not making a judgment on the overall validity of such discussion where this does not exist, but indeed it can be viewed as somewhat 'masturbatory' and usually devolves rather than evolves as a form of worthy discussion on the topic at hand
 
Smyth said:
Are you sure about the NMDA antagonist thing? I think ive read about methadone being one, and possibly also ketobemidone, but I dont know about strength. For instance, sertraline is a potentish DARI (25 nM) in vitro. However it's SERT affinity is subnanomolar so for all intents and purposes it behaves as an SSRI.

In response to F&B, there are quite a few people who have seriously cut-back on their post count, not because they have no interest in drugs. The reason is that they dont see the purpose in talking about stuff just for the sake of it. The molecule is not available commercially, and nobody has the ability to lay their hands on it. Therefore of what real-world significance is it other than giving people something to babble about?

It just seems utterly pointless without any literature to back it up with to post the structure of a molecule (usually just a half-assed sketch in chemdraw) and say "here, what do you think of my "discovery" guys? I have no way of making this in a lab but somebody should do, and then I will take all of the credit for this great idea ;)" This is more in cases where the guy posting the molecule/s has no formal knowledge of chemistry and is posting structures of stuff without the first clue of how one would go about making them. In such cases it seems totally amateurish. But in credit to the thread poster, at least in this case the molecule actually has been made and is not just pie in the sky.
Click to expand...


What's the rule about suppliers etc?
 
Last edited by a moderator:
^Exactly. That proves I was not having a personal dig at the OP, although I had no idea at the time of writing that it is commercially available. In that case, let the good times roll...
 
I know what you're saying, and I'm about 50/50 in and out of agreement with you.
 
If I was being rude about it I would have stepped in and said something like "STFU" or "nobody cares!" but it was not my intention to offend anybody.

But my original question about whether or not the question was something that demanded an answer was actually a genuine one and not just an attempt to undermine peoples confidence or deter them from making posts to the board.
 
You must log in or register to reply here.
Top