The LSD-025/mitragynine hybrid I posted the other day and colloquially named, 'Dior Amadeus,' has a super interesting property: Namely, it goes from being a mydriatic stimulant to a miosis producing opiate roughly 12 (6 to 24) hours later.
The reason for this property is that the piperidine ring with one double bond probably gets metabolically aromatized by the body's aromatase enzyme to a toxic pyridinium species whose cationic nitrogen no longer supports the stimulatory activity brought about by the methamphetamine pharmacophore found in the structures of both LSD-025 and Dior Amadeus.
Additionally, the nitrogen atom found in the mitragynine portion of Dior Amadeus still activates the strong opioid activity (pin point pupils, for example) noted a day or two into a Dior Amadeus session.