Limpet_Chicken
Bluelighter
- Joined
- Oct 13, 2005
- Messages
- 6,323
Alright...this is a bit...different, normally I'd put a question like this in OD.
However, this is of a sufficiently different kind of drug to be rather far out of the sphere of the usual experience range in OD. So, here it is going.
What is people's take here on the thought of a speedball, but rather than using a conventional DA/NA releaser, DARI or releaser-reuptake inhibitor, for the stimulant portion of a speedball, use of a delta opioid agonist? the one, or ligand I am as certain as I can be without setting up to perform a radioligand binding assay, that I have in mind is alpha-chloromorphide, which, since at the highest dose levels tried, although not at lower ones, there was mild clonus of the hands and feet, fingers. Nothing particularly threatening but I wouldn't push it higher than I did try, at a couple of hundred mg (tolerant to MOR agonists, not sure if that provides any crosstolerance with DOR ligands)
I am pretty confident that it is at least a DOR1 agonist, due to the clonus at high levels, but have no way of determining if it may be a DOR2 agonist also.
I'll test that out as soon as I can afford to, although I'm pretty snowed under at the moment. And have nothing to spare, money-wise, since I do have to eat something that isn't spent on the ol' skunk-works. Thankfully I don't tend to eat all that much anyway But this one has me curious, as it is SO like a psychostimulant, but coming from morphine, as a backbone and such a modest structural modification, I am pretty sure that it is an opioid of SOME variety. It does, after all relieve MOR agonist (morphine, oxy, dipropionyl or dibenzoylmorphine esters, opium, codeine, DHC. ) withdrawals
forgot to specify-the opiate(s) I had in mind are either dipropionylmorphine, desomorphine-D, or both.
However, this is of a sufficiently different kind of drug to be rather far out of the sphere of the usual experience range in OD. So, here it is going.
What is people's take here on the thought of a speedball, but rather than using a conventional DA/NA releaser, DARI or releaser-reuptake inhibitor, for the stimulant portion of a speedball, use of a delta opioid agonist? the one, or ligand I am as certain as I can be without setting up to perform a radioligand binding assay, that I have in mind is alpha-chloromorphide, which, since at the highest dose levels tried, although not at lower ones, there was mild clonus of the hands and feet, fingers. Nothing particularly threatening but I wouldn't push it higher than I did try, at a couple of hundred mg (tolerant to MOR agonists, not sure if that provides any crosstolerance with DOR ligands)
I am pretty confident that it is at least a DOR1 agonist, due to the clonus at high levels, but have no way of determining if it may be a DOR2 agonist also.
I'll test that out as soon as I can afford to, although I'm pretty snowed under at the moment. And have nothing to spare, money-wise, since I do have to eat something that isn't spent on the ol' skunk-works. Thankfully I don't tend to eat all that much anyway But this one has me curious, as it is SO like a psychostimulant, but coming from morphine, as a backbone and such a modest structural modification, I am pretty sure that it is an opioid of SOME variety. It does, after all relieve MOR agonist (morphine, oxy, dipropionyl or dibenzoylmorphine esters, opium, codeine, DHC. ) withdrawals
forgot to specify-the opiate(s) I had in mind are either dipropionylmorphine, desomorphine-D, or both.