dopamine depleted after picamilon + amphetamine?

[logarithm]

Hey,
I was working a lot and noticed that the effect of my daily amphetamines (20 mg a day in two doses) was not as good as some months ago. So I decided to add 2x a day 150 mg picamilon. This was very very good. Much better work performance. Now after 20 days I'm not able to concentrate anymore. From one day to another I have no mental energy anymore... WTF happened??? I feel no urge anymore to work. It's like i'm pretty relaxed but I know I need to work now, but can't ... Very bizarre situation... Is dopamine depleted? Is the picamilon gaba diminuishing the amps more and more? I really dont know...

logarithm

 

[laCster]

Dude amphetamine usage daily will definitely deplete dopamine and serotonin.

Lay off the amphetamines for a week or two and exercise and eat a proper diet. Exercise tremendously helps the production of dopamine and serotonin and other vital neurotransmitters. Also you gut is the number one producer of serotonin and if you eat right,
Your body will reach homeostasis more quickly.


The picamilon probably dis jack shit honestly, it won't do much besides maybe control anxiety a little.


After you take a break, DO NOT use amphetamines daily. Amps are known to deplete dopamine, and other nutrients and vitamins. You have to give your body time to recoup and procure dopamine and serotonin.

Do your body and mind a favor and stop taking amphetamines daily. Every other day is pushing it. But I usually wait atleast 3-5 days between taking amps.

 

[Jabberwocky]

Frankly, if you're taking the doses as prescribed and properly (not pushing past 40mg one day) you shouldn't be battling tolerance as harshly. I've found that a ZMA supplement at night along with a multivitamin during the day has perhaps stopped me from building a tolerance, as i've been on 40mg of dexedrine daily for the past year and suffered no loss of theraputic effects.

 

[Crashing]

What laCster said is pretty much all my thoughts. Using amps daily = depletion, and there's no way to avoid it. You probably need a long break to normalize, probably around a month and then you could resume but you probably only wanna take it a few times a week at most.

 

[logarithm]

My doctor says: Therapeutic dose -> no tolerance. But when working hard I always noticed that the working performance is decreasing after some days or weeks, But guess thats normal. Probably I'm burned out and don't get it because the gaba from picamilon gives me a "I don't care" mood.

 

[laCster]

Dude the gaba is placebo, it does not cross the bbb well. It's not that, it might make you less anxious, but its not like taking a benzo which gives you a fuck it attitude.
I know more about drugs than most docs, and most doctors are fuckn retards.y drug will cause tolerance, how the fuck can your doctor say it doesn't cause tolerance? Of course it does. Just like how when you exercise or lift weights, after a while you will be able to exercise for longer periods of time and lift heavier weights. Your body adapts, just like it does to the cold, just like how practicing math makes it easier to do math.

Your doc is a retard

 

[logarithm]

sometimes I think he is a retard.

But you can do math without getting better at it. Also you can lift weights without getting better at it. The strongness of the reaction depends on the force of the stimulus. If you keep your dose under a certain treshold, it should work. I take stimulants since 15 years, most of the time everyday.... And something like that never happened before, even at much higher doses. (ok, the higher doses were on methylphenidate, but no tolerance).

The cool feature picamion possesses is, it can cross the brain blood barrier. Then it splits into niacin and gaba, which will probably work synergistically (Somewhere I was reading that niacin stimulates a Gaba receptor).

 

[logarithm]

I managed my university stuff and I learned something about my dopamine system: Theres a finite amount of dopamine and mental activity or stress uses this dopamine up. If you rest, you get new dopamine. So if you work a lot and have much stress it might be the case that you deplete more dopamine than you get back. If you do this some longer time, your dopamine amount will be used up and you try to drive your car without fuel. With substances you can influence your dopamine system, which I did. I used picamilon which increased the effect of amphetamine and increased my working performance. But it just delayed the burn out again. At the point when the stimulatory component didn't worked anymore, I felt the other component of that combination way more pronounced. The stimulating effect of picamilon was almost non existent anymore, but gaba seemed to work. Them when not using picamilon after that point anymore, the gaba like, mild sedating, antidepressive and antianxiolytic effect disappeared. Later, after realizing that recovery for restablishing working performance would take too long, I tried piracetam with amphetamines. And this combo was very strong. I lowered the doses and then as stress increased and recovery time decreased, I could carefully upper the doses of piracetam and amphetamine. In the end it all just worked out. After the thesis, I recovered. I tried to keep the priacetam and amphetamine combo, but I reduced the dosages. Resting restored my capacities. The effect of this combination, although with reduced dosage, got pretty strong. And the dosage is so low, that for reducing the effect I would need to reduce the dosage of one substance to zero....